Results 61 to 70 of about 293 (242)

Semilocal convergence of a Secant-type method under weak Lipschitz conditions in Banach spaces [PDF]

, 2018
[EN] The semilocal convergence of double step Secant method to approximate a locally unique solution of a nonlinear equation is described in Banach space setting. Majorizing sequences are used under the assumption that the first-order divided differences
Abhimanyu Kumar, Eulalia Martínez, D.K. Gupta, Sukhjit Singh, Singh, Sukhjit, Kumar, A., Gupta, D.K., Martínez Molada, Eulalia   +7 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Fast Algorithms for Designing Complementary Sets of Sequences Under Multiple Constraints

IEEE Access, 2019
Complementary sets of sequences (CSSs) are widely used in many applications, such as active sensing and wireless communication. The construction of CSS has attracted considerable attention over the past few decades.
Zhong-Jie Wu, Tian-Liang Xu, Zhi-Quan Zhou, Chen-Xu Wang   +3 more
doaj   +1 more source

High-throughput sequencing of the synaptome in major depressive disorder [PDF]

Molecular Psychiatry, 2015
Major depressive disorder (MDD) is among the leading causes of worldwide disability. Despite its significant heritability, large-scale genome-wide association studies (GWASs) of MDD have yet to identify robustly associated common variants. Although increased sample sizes are being amassed for the next wave of GWAS, few studies have as yet focused on ...
M, Pirooznia, T, Wang, D, Avramopoulos, J B, Potash, P P, Zandi, F S, Goes   +5 more
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Extended Parametric Family of Two-Step Methods with Applications for Solving Nonlinear Equations or Systems

Axioms
The parametric family of two-step methods, with its special cases, has been introduced in various papers. However, in most cases, the local convergence analysis relies on the existence of derivatives of orders that the method does not require.
Ioannis K. Argyros, Stepan Shakhno, Mykhailo Shakhov   +2 more
doaj   +1 more source