Annals of Human Genetics, Volume 89, Issue 4, Page 178-187, July 2025.Abstract Background Dyslipidemia is becoming prevalent in Africa, where malaria is endemic. Observational studies have documented the long‐term protective effect of malaria on dyslipidemia; however, these study designs are prone to confounding. Therefore, we used Mendelian randomization (MR, a method robust to confounders and reverse causation) to ...
Mariam Traore +12 more
wiley +1 more source
Endothelial transcriptomic analysis identifies biomarkers of severe and cerebral malaria
JCI Insight, 2023 Malaria can quickly progress from an uncomplicated infection into a life-threatening severe disease. However, the unspecificity of early symptoms often makes it difficult to identify patients at high risk of developing severe disease.
Cláudia Gomes +8 more
doaj +1 more source
Microarray Analysis of PBMC after Plasmodium falciparum Infection: Molecular Insights into Disease Pathogenesis [PDF]
, 2011 Our laboratory’s previous microarray analysis of subjects with Plasmodium falciparum revealed up-regulation of Toll-like receptor, NF-kB, TNF-α, IFN-γ, IL-1β, p38 MAPK, and MHC molecules.
Alan Scott +5 more
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Innate immunity and neuroinflammation [PDF]
, 2013 Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Bonifati, DM, Kishore, U, Shastri, A
core +3 more sources
The contribution of extracellular RNA and its derived biomaterials in disease management
BMEMat, Volume 3, Issue 2, June 2025.The implications of exRNA's biological function and the structural uniqueness of RNA help establish a close connection between RNA, material, and modern medicine. Abstract The RNA found in the circular system is known as extracellular RNA (exRNA). This kind of RNA has been found to play a biological role similar to that of a messenger. They can be used
Yu Wei +8 more
wiley +1 more source
Human cerebral malaria and
Malaria Journal, 2012 Background Cerebral malaria, a severe form of Plasmodium falciparum infection, is an important cause of mortality in sub-Saharan African children.
Milner Danny A +21 more
doaj +1 more source
Virulence of malaria is associated with differential expression of Plasmodium falciparum var gene subgroups in a case-control study [PDF]
, 2006 Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a major pathogenicity factor in falciparum malaria that mediates cytoadherence. PfEMP1 is encoded by approximately 60 var genes per haploid genome.
Baea, Kay +5 more
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Epidemiological, clinical and therapeutic aspects of cerebral malaria imported in Albania
Journal of Infection in Developing Countries, 2016 This is a case-report of two patients with cerebral malaria (CM) imported from West-African countries. Notably, this form of malaria was developed as a second disease episode, while the first episode was experienced in West Africa. These findings suggest
Arben Ndreu +9 more
doaj +1 more source
Coma in fatal adult human malaria is not caused by cerebral oedema [PDF]
, 2011 BACKGROUND: The role of brain oedema in the pathophysiology of cerebral malaria is controversial. Coma associated with severe Plasmodium falciparum malaria is multifactorial, but associated with histological evidence of parasitized erythrocyte ...
Arjen M Dondorp +8 more
core +4 more sources
The Case for the Use of PPARγ Agonists as an Adjunctive Therapy for Cerebral Malaria
PPAR Research, 2012 Cerebral malaria is a severe complication of Plasmodium falciparum infection associated with high mortality even when highly effective antiparasitic therapy is used.
Lena Serghides
doaj +1 more source