Results 91 to 100 of about 966,112 (203)
Clinical and Vaccine Immunology, 2017 Proinflammatory cytokines are involved in clearance of Plasmodium falciparum, and very high levels of these cytokines have been implicated in the pathogenesis of severe malaria. In order to determine how cytokines vary with disease severity and syndrome,
W. Mandala +5 more
semanticscholar +1 more source
Anemia, Volume 2026, Issue 1, 2026.Background Malaria remains a major global health burden, with red blood cell (RBC) polymorphisms conferring partial protection. However, the epistatic interactions among co‐inherited RBC polymorphisms are poorly understood. We aimed to characterise how epistatic interactions among malaria‐protective RBC polymorphisms modify risk across the infection‐to‐
George Paasi +11 more
wiley +1 more source
Epidemiological, clinical and therapeutic aspects of cerebral malaria imported in Albania
Journal of Infection in Developing Countries, 2016 This is a case-report of two patients with cerebral malaria (CM) imported from West-African countries. Notably, this form of malaria was developed as a second disease episode, while the first episode was experienced in West Africa. These findings suggest
Arben Ndreu +9 more
doaj +1 more source
Targeting the IL33–NLRP3 axis improves therapy for experimental cerebral malaria
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Cerebral malaria (CM) is a neurological complication of malaria infection that, despite antimalarial drug treatment, results in fatality or neurodisability in approximately 25% of cases.
Patrick Strangward +16 more
semanticscholar +1 more source
The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease
Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Caroline de Souza Ferreira Pereira +2 more
wiley +1 more source
The Case for the Use of PPARγ Agonists as an Adjunctive Therapy for Cerebral Malaria
PPAR Research, 2012 Cerebral malaria is a severe complication of Plasmodium falciparum infection associated with high mortality even when highly effective antiparasitic therapy is used.
Lena Serghides
doaj +1 more source
Modulation of cerebral malaria by curcumin as an adjunctive therapy
Brazilian Journal of Infectious Diseases, 2013 Cerebral malaria is the most severe and rapidly fatal neurological complication of Plasmodium falciparum infection and responsible for more than two million deaths annually.
Kunal Jain +2 more
doaj +1 more source
Scientific Reports, 2017 Curcumin has many pharmacological activities despite its poor bioavailability and in vivo stability. Here, we show that a nanoformulated curcumin (PLGA-curcumin) has better therapeutic index than native curcumin in preventing the onset of neurological ...
Chaitanya Dende +5 more
semanticscholar +1 more source
A quantitative brain map of experimental cerebral malaria pathology
PLoS Pathogens, 2017 The murine model of experimental cerebral malaria (ECM) has been utilised extensively in recent years to study the pathogenesis of human cerebral malaria (HCM).
Patrick Strangward +16 more
semanticscholar +1 more source
Medical Journal of Australia, Volume 224, Issue 1, January 2026.ABSTRACT A man aged in his 40s, recently returned from Uganda, was hospitalised with Plasmodium falciparum malaria, with hyperparasitaemia of ~1.5 × 106 parasites/μL (26%). He received intravenous artesunate followed by artemether–lumefantrine. However, parasite clearance was delayed, and despite a negative blood film following treatment, the patient ...
Jye Travis +6 more
wiley +1 more source