Results 101 to 110 of about 966,112 (203)

Differential plasma microvesicle and brain profiles of microRNA in experimental cerebral malaria

Malaria Journal, 2018
BackgroundCerebral malaria (CM) is a fatal complication of Plasmodium infection, mostly affecting children under the age of five in the sub-Saharan African region.
A. Cohen, Anna Zinger, N. Tiberti, G. Grau, V. Combes   +4 more
semanticscholar   +1 more source

Pathogenesis of Cerebral Malaria: New Diagnostic Tools, Biomarkers and Therapeutic Approaches

Frontiers in Cellular and Infection Microbiology, 2015
Cerebral malaria is a severe neuropathological complication of Plasmodium falciparum infection. It results in high mortality and post-recovery neuro-cognitive disorders in children, even after appropriate treatment with effective anti-parasitic drugs ...
Praveen Kishore Sahu, Sanghamitra eSatpathi, Prativa eBehera, Saroj Kanti Mishra, Sanjib eMohanty, Samuel C Wassmer, Samuel C Wassmer   +6 more
doaj   +1 more source

Plasmodium vivax cerebral malaria with pancytopenia in the peruvian amazon: case report. [PDF]

Rev Peru Med Exp Salud Publica, 2022
Paredes-Obando M, Moreno A, Panduro-García E, Ferreyra A, Chuquipiondo-Galdos D, Vásquez Ascate JJ, Sibina-Vela J, Ramírez-García EA, Celis-Salinas JC, Casapía-Morales M.   +9 more
europepmc   +1 more source

Children with cerebral malaria or severe malarial anaemia lack immunity to distinct variant surface antigen subsets

Scientific Reports, 2018
Variant surface antigens (VSAs) play a critical role in severe malaria pathogenesis. Defining gaps, or “lacunae”, in immunity to these Plasmodium falciparum antigens in children with severe malaria would improve our understanding of vulnerability to ...
M. Travassos, Amadou Niangaly, Jason A. Bailey, A. Ouattara, D. Coulibaly, K. Lyke, M. Laurens, Jozelyn V. Pablo, A. Jasinskas, R. Nakajima, Andrea A. Berry, Matthew Adams, Christopher G. Jacob, A. Pike, Shannon Takala-Harrison, Li Liang, B. Kouriba, A. Kone, J. A. Rowe, J. Moulds, D. Diallo, O. Doumbo, M. Thera, P. Felgner, C. Plowe   +24 more
semanticscholar   +1 more source

IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria

PLoS Pathogens, 2017
Cerebral malaria (CM) is associated with a high mortality rate and long-term neurocognitive impairment in survivors. The murine model of experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA)-infection reproduces several of these ...
F. Reverchon, S. Mortaud, Maëliss Sivoyon, I. Maillet, A. Laugeray, J. Palomo, C. Montécot, Améziane Herzine, S. Même, W. Même, F. Erard, B. Ryffel, A. Menuet, V. Quesniaux   +13 more
semanticscholar   +1 more source

Murine malaria is associated with significant hearing impairment

Malaria Journal, 2010
Background Plasmodium falciparum malaria has been suspected to cause hearing loss. Developmental, cognitive and language disorders have been observed in children, surviving cerebral malaria.
Stephan Kurt, Reindl Markus, Glueckert Rudolf, Fischer Marlene, Dietmann Anelia, Lackner Peter, Kositz Christian H, Schmutzhard Joachim, Riechelmann Herbert, Schrott-Fischer Annelies, Schmutzhard Erich   +10 more
doaj   +1 more source

A shared inflammatory signature across severe malaria syndromes manifested by transcriptomic, proteomic and metabolomic analyses

Nature Communications
Factors governing the clinical trajectory of Plasmodium falciparum infection remain an important area of investigation. Here we present transcriptomic, proteomic and metabolomic analyses comparing clinical subtypes of severe Plasmodium falciparum malaria
Rafal S. Sobota, Emily M. Stucke, Drissa Coulibaly, Jonathan G. Lawton, Bryan E. Cummings, Savy Sebastian, Antoine Dara, James B. Munro, Amed Ouattara, Abdoulaye K. Kone, Bourama Kane, Karim Traoré, Bouréima Guindo, Bourama M. Tangara, Amadou Niangaly, Noah T. Ventimiglia, Modibo Daou, Issa Diarra, Youssouf Tolo, Mody Sissoko, Fayçal Maiga, Aichatou Diawara, Amidou Traore, Ali Thera, Matthew B. Laurens, Kirsten E. Lyke, Bourema Kouriba, Ogobara K. Doumbo, Christopher V. Plowe, David R. Goodlett, Joana C. Silva, Mahamadou A. Thera, Mark A. Travassos   +32 more
doaj   +1 more source

miR-155 Modifies Inflammation, Endothelial Activation and Blood-Brain Barrier Dysfunction in Cerebral Malaria

Molecular Medicine, 2017
miR-155 has been shown to participate in host response to infection and neuroinflammation via negative regulation of blood-brain barrier (BBB) integrity and T cell function.
K. Barker, Ziyue Lu, Hani Kim, Ying Zheng, Junmei Chen, A. Conroy, M. Hawkes, Henry S. Cheng, Makon-Sébastien NJOCK, Jason E. Fish, J. Harlan, José A López, W. Liles, K. Kain   +13 more
semanticscholar   +1 more source

Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria

BMC Medicine, 2017
BackgroundExpression of group A and the A-like subset of group B Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is associated with severe malaria (SM).
E. Shabani, B. Hanisch, R. Opoka, T. Lavstsen, C. John   +4 more
semanticscholar   +1 more source

Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α+thalassaemia

eLife, 2018
Malaria has been a major driving force in the evolution of the human genome. In sub-Saharan African populations, two neighbouring polymorphisms in the Complement Receptor One (CR1) gene, named Sl2 and McCb, occur at high frequencies, consistent with ...
D. Opi, O. Swann, A. Macharia, S. Uyoga, G. Band, Carolyne M. Ndila, E. Harrison, M. Thera, A. Kone, D. Diallo, O. Doumbo, K. Lyke, C. Plowe, J. Moulds, M. Shebbe, N. Mturi, N. Peshu, K. Maitland, A. Raza, D. Kwiatkowski, K. Rockett, T. Williams, J. A. Rowe   +22 more
semanticscholar   +1 more source