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Imaging features of fulminant cerebral malaria: A case report
Radiology Case Reports, 2023 Cerebral malaria is associated with high mortality and morbidity in patients infected with Plasmodium Falciparum. The mechanisms of cerebral malaria include sequestration of parasitized red blood cells in brain capillaries, production of cytokines ...
Ahmed El Beltagi +4 more
doaj +1 more source
Cerebral malaria is associated with differential cytoadherence to brain endothelial cells
EMBO Molecular Medicine, 2019 Sequestration of Plasmodium falciparum‐infected erythrocytes (IE) within the brain microvasculature is a hallmark of cerebral malaria (CM). Using a microchannel flow adhesion assay with TNF‐activated primary human microvascular endothelial cells, we ...
J. Storm +11 more
semanticscholar +1 more source
Desperately Seeking Therapies for Cerebral Malaria
Journal of Immunology, 2020 Malaria is a deadly infectious disease caused by parasites of the Plasmodium spp. that takes an estimated 435,000 lives each year, primarily among young African children. For most children, malaria is a febrile illness that resolves with time, but in ∼1%
Brittany A. Riggle, L. Miller, S. Pierce
semanticscholar +1 more source
Malaria Journal, 2005 Background IL-1β and IL-1RA levels are higher in the serum of cerebral malaria patients than in patients with mild malaria. Recently, the level of IL1B expression was reported to be influenced by a polymorphism in the promoter of IL1, IL1B -31C>T ...
Tangpukdee Noppadon +7 more
doaj +1 more source
Immunological Reviews, 2019 Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites have the unique capacity to infect and replicate within host erythrocytes.
Anja T. R. Jensen +2 more
semanticscholar +1 more source
Delayed gastric emptying time in adult cerebral falciparum malaria [PDF]
Journal of Vector Borne Diseases, 2012 Objective: We hypothesize that upper gastrointestinal symptoms in cerebral malaria are due to gastric motordysfunction. But gastric motility studies in cerebral malaria are scarce.Methods: We determined gastric emptying half-time (GET½) of liquid meals ...
M.K. Mohapatra , P.C. Dash , S.C. Mohapatro & R.N. Mishra
doaj
CD8+ T cells target cerebrovasculature in children with cerebral malaria.
Journal of Clinical Investigation, 2019 BACKGROUND Cerebral malaria (CM) accounts for nearly 400,000 deaths annually in African children. Current dogma suggests that CM results from infected RBC (iRBC) sequestration in the brain microvasculature and resulting sequelae.
Brittany A. Riggle +11 more
semanticscholar +1 more source
Plasmodium coatneyi-infected rhesus monkeys: a primate modelfor human cerebral malaria
Memorias do Instituto Oswaldo Cruz, 1992 Although several animal models for human cerebral malaria have been proposed in the past, name have shown pathological findings that are similar to those seen in humans.
Masamichi Aikawa +8 more
doaj +1 more source
Biomedicine & Pharmacotherapy, 1989 Cerebral malaria is the most important manifestation of severe Plasmodium falciparum infection. The clinical picture in South East Asian adults differs from that in African children. The children are more likely to have abnormal brain stem reflexes, signs suggestive of cerebral herniation, and raised CSF opening pressure, and to suffer persistent ...
openaire +4 more sources
Parasites & Vectors, 2018 Background Cerebral malaria, the main complication of Plasmodium falciparum infection in humans, is associated with persistent neurocognitive sequels both in human disease and the murine experimental model.
Luciana Pereira de Sousa +6 more
doaj +1 more source