Results 51 to 60 of about 966,112 (203)

Elevated plasma von Willebrand factor and propeptide levels in Malawian children with malaria. [PDF]

PLoS ONE, 2011
In spite of the significant mortality associated with Plasmodium falciparum infection, the mechanisms underlying severe disease remain poorly understood.
Happy T Phiri, Daniel J Bridges, Simon J Glover, Jan A van Mourik, Bas de Laat, Bridon M'baya, Terrie E Taylor, Karl B Seydel, Malcolm E Molyneux, E Brian Faragher, Alister G Craig, James E G Bunn   +11 more
doaj   +1 more source

The Ins and Outs of Cerebral Malaria Pathogenesis: Immunopathology, Extracellular Vesicles, Immunometabolism, and Trained Immunity

Frontiers in Immunology, 2019
Complications from malaria parasite infections still cost the lives of close to half a million people every year. The most severe is cerebral malaria (CM). Employing murine models of CM, autopsy results, in vitro experiments, neuroimaging and microscopic
F. Sierro, G. Grau
semanticscholar   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Gene expression profiling in blood from cerebral malaria patients and mild malaria patients living in Senegal

BMC Medical Genomics, 2019
Background Plasmodium falciparum malaria remains a major health problem in Africa. The mechanisms of pathogenesis are not fully understood. Transcriptomic studies may provide new insights into molecular pathways involved in the severe form of the disease.
Alassane Thiam, Michel Sanka, Rokhaya Ndiaye Diallo, Magali Torres, Babacar Mbengue, Nicolas Fernandez Nunez, Fatou Thiam, Gora Diop, Geneviève Victorero, Catherine Nguyen, Alioune Dieye, Pascal Rihet   +11 more
doaj   +1 more source

Curvy Surface Reconstruction

Advanced Science, EarlyView.
This review introduces the concept of “general curvy surface reconstruction,” which incorporates both geometric and physical dimensions, representing an upgrade over conventional geometric reconstruction that focuses solely on spatial relationships. Particular emphasis is placed on the emerging opportunities enabled by advanced measurement techniques ...
Chen Shang, Haoyu Qi, Zhigang Wang, Keyu Meng, Zeye Liu, Zeng Meng, Yu Yang, Jianjun Wang, Shan Jiang   +8 more
wiley   +1 more source

Evaluating predictive values of umbilical cord arterial lactate for adverse newborn outcomes among term‐births in northern Uganda: A cross sectional analytical study

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 408-420, April 2025.
Abstract Objective Birth asphyxia is one of the leading causes of death for neonates worldwide. Lack of an objective cost effective test to predict poor newborn outcomes at birth affects the ability to respond appropriately. This study determined predictive values of umbilical cord arterial lactate in relation to adverse neonatal outcomes. Methods This
Elizabeth Ayebare, James K. Tumwine, Jolly Nankunda, Anna Hjelmstedt, Wibke Jonas, Grace Ndeezi, Nicola Orsini, Claudia Hanson   +7 more
wiley   +1 more source

Differences in gene transcriptomic pattern of Plasmodium falciparum in children with cerebral malaria and asymptomatic carriers. [PDF]

PLoS ONE, 2014
The mechanisms underlying the heterogeneity of clinical malaria remain largely unknown. We hypothesized that differential gene expression contributes to phenotypic variation of parasites which results in a specific interaction with the host, leading to ...
Talleh Almelli, Grégory Nuel, Emmanuel Bischoff, Agnès Aubouy, Mohamed Elati, Christian William Wang, Marie-Agnès Dillies, Jean-Yves Coppée, Georges Nko Ayissi, Leonardo Kishi Basco, Christophe Rogier, Nicaise Tuikue Ndam, Philippe Deloron, Rachida Tahar   +13 more
doaj   +1 more source

Shifts in the clinical epidemiology of severe malaria after scaling up control strategies in Mali

Frontiers in Neurology, 2022
A decrease in malaria incidence following implementation of control strategies such as use of artemisinin-based combination therapies, insecticide-impregnated nets, intermittent preventive treatment during pregnancy and seasonal malaria chemoprevention ...
Drissa Coulibaly, Abdoulaye K. Kone, Bourama Kane, Bouréima Guindo, Bourama Tangara, Mody Sissoko, Fayçal Maiga, Karim Traore, Aichatou Diawara, Amidou Traore, Ali Thera, Mahamadou S. Sissoko, Ogobara K. Doumbo, Mark A. Travassos, Mahamadou A. Thera   +14 more
doaj   +1 more source

Neurodevelopmental Impairments 1 Year After Cerebral Malaria

Pediatrics, 2019
Neurodevelopmental impairments persist at 1-year assessments in one-half of the survivors of CM and are associated with HIV, stunting, severity of illness, and MRI abnormalities.
J. Langfitt, M. Mcdermott, Rachel Brim, S. Mboma, M. Potchen, S. Kampondeni, K. Seydel, M. Semrud‐Clikeman, T. Taylor   +8 more
semanticscholar   +1 more source

The interacting etiologies of hippocampal sclerosis in epilepsy: A scoping review

Epilepsia, EarlyView.
Abstract According to the International League Against Epilepsy classification, mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE‐HS) is considered an epilepsy syndrome. Several etiologies may precede HS, but there is little overview in the literature about these etiologies.
Boris Deleu, Jules Jeuris, Wim Van Paesschen   +2 more
wiley   +1 more source