Objective: To know whether the effect of interferon-induced protein with tetratricopeptide repeats (IFIT) 1 polymorphism influences the susceptibility of cerebral malaria outcome.
Saw Thu Wah+5 more
doaj +1 more source
Toll-like receptor polymorphisms and cerebral malaria:
Background In malaria endemic areas, host genetics influence whether a Plasmodium falciparum-infected child develops uncomplicated or severe malaria. TLR2 has been identified as a receptor for P. falciparum-derived glycosylphosphatidylinositol (GPI), and
BT Grimberg+32 more
core +1 more source
ABSTRACT Background The greatest burden of sickle cell disease (SCD) globally occurs in sub‐Saharan Africa, where significant morbidity occurs secondary to SCD‐induced vasculopathy and stroke. Transcranial doppler (TCD) ultrasound grades the severity of vasculopathy, with disease modifying therapy resulting in stroke risk reduction in high‐risk ...
Derby Tembo+18 more
wiley +1 more source
Background In developing countries where Plasmodium falciparum malaria is endemic, viral encephalitis and cerebral malaria are found in the same population, and parasitemia with Plasmodium falciparum is common in asymptomatic children.
Atmakuri RM+3 more
doaj +1 more source
Differential var Gene Expression in Children with Malaria and Antidromic Effects on Host Gene Expression [PDF]
Among 62 children with mild malaria, cerebral malaria, or severe malarial anemia, we analyzed the transcription of different var gene types. There was no difference in parasitemia level or body temperature between groups.
Beck, Hans-Peter+5 more
core
Natural regulatory (CD4+CD25+FOXP+) T cells control the production of pro-inflammatory cytokines during Plasmodium chabaudi adami infection and do not contribute to immune evasion. [PDF]
Different functions have been attributed to natural regulatory CD4+CD25+FOXP+ (Treg) cells during malaria infection. Herein, we assessed the role for Treg cells during infections with lethal (DS) and non-lethal (DK) Plasmodium chabaudi adami parasites ...
Belanger, B+4 more
core +1 more source
The 15‐Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging
Human aging shows puzzling diversity: similar aging rates yet vastly different health outcomes. Our study of ~17,500 people revealed a health‐promoting trait (more common in women) linked to strong immune resilience and high expression of TCF7, a key immune gene. This trait enables individuals to fight infections like COVID‐19 more effectively, respond
Muthu Saravanan Manoharan+176 more
wiley +1 more source
Hemiparesis post cerebral malaria
Cerebral malaria is one of the most serious complications in the Plasmodium falciparum infection. In endemic areas, the cerebral malaria interested mainly children.
Oumkaltoum Taiaa+2 more
doaj +1 more source
STATUS HEMATOLOGI PENDERITA MALARIA SEREBRAL
AbstrakMalaria masih merupakan masalah kesehatan masyarakat dunia. Berdasarkan klasifikasi klinis, malaria dibedakan atas malaria berat dan malaria tanpa komplikasi.
Nurhayati Nurhayati
doaj +1 more source
Plasmodium falciparum histidine-rich protein II causes vascular leakage and exacerbates experimental cerebral malaria in mice. [PDF]
A devastating complication of Plasmodium falciparum infection is cerebral malaria, in which vascular leakage and cerebral swelling lead to coma and often death. P. falciparum produces a protein called histidine-rich protein II (HRPII) that accumulates to
Priya Pal+5 more
doaj +1 more source