Results 81 to 90 of about 50,084 (222)

Methylene Blue-Based Combination Therapy with Amodiaquine Prevents Severe Malaria in an Experimental Rodent Model

Pharmaceutics, 2022
Untreated malaria can progress rapidly to severe forms (
Jérôme Dormoi, Rémy Amalvict, Mathieu Gendrot, Bruno Pradines   +3 more
doaj   +1 more source

Severe childhood malaria syndromes defined by plasma proteome profiles [PDF]

, 2012
BACKGROUND Cerebral malaria (CM) and severe malarial anemia (SMA) are the most serious life-threatening clinical syndromes of Plasmodium falciparum infection in childhood.
A Hodgetts, Adebola E. Orimadegun, AE Orimadegun, AK Rowe, AL Conroy, Barry K. Ely, Biobele J. Brown, C Wu, D Agranoff, Delmiro Fernandez-Reyes, Dimitrios Athanasakis, FE Lovegrove, Felix O. Akinbami, Florence Burté, Francesca Battaglia, Francis Akinkunmi, FX Wu, G Sandhu, J Amzat, J Bryce, K Marsh, Kevin KA. Tetteh, Kikelomo Osinusi, LK Erdman, MC Papadopoulos, Nathaniel K. Afolabi, Olayinka Kowobari, Olugbemiro Sodeinde, RT Pang, RW Snow, S Rojas-Galeano, Samuel Omokhodion, SI Hay, SI Hay, SJ Ceesay, Wasiu A. Ajetunmobi, Wuraola A. Shokunbi   +36 more
core   +3 more sources

Risk factors associated with progression from pre‐eclampsia to eclampsia: A prospective cohort study and population‐wide data analysis

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Younger maternal age and lower socioeconomic status emerged as key risk factors for progression from pre‐eclampsia to eclampsia in two low‐ and middle‐income countries (Uganda and Ecuador), challenging the traditional focus on disease severity alone. This suggests a need to broaden risk assessment criteria.
Annettee Nakimuli, Brittany A. Jasper, Sarah Nakubulwa, Moses Adroma, Jackline Akello, Imelda Namagembe, Musa Sekikubo, Eve Nakabembe, Ashley Moffett, Catherine E. Aiken   +9 more
wiley   +1 more source

Increased Survival in B-Cell-Deficient Mice during Experimental Cerebral Malaria Suggests a Role for Circulating Immune Complexes

mBio, 2014
The pathogenesis of malaria, an insect-borne disease that takes millions of lives every year, is still not fully understood. Complement receptor 1 (CR1) has been described as a receptor for Plasmodium falciparum, which causes cerebral malaria in humans ...
Rosane B. de Oliveira, Jennifer P. Wang, Sanjay Ram, Ricardo T. Gazzinelli, Robert W. Finberg, Douglas T. Golenbock   +5 more
doaj   +1 more source

Single molecule and multiple bond characterization of catch bond associated cytoadhesion in malaria [PDF]

, 2017
The adhesion of malaria infected red blood cells (iRBCs) to host endothelial receptors in the microvasculature, or cytoadhesion, is associated with severe disease pathology such as multiple organ failure and cerebral malaria.
Cao, Jianshu, Lim, Chwee-Teck, Lim, Ying Bena, Thingna, Juzar   +3 more
core   +1 more source

Imaging malaria parasites across scales and time

Journal of Microscopy, EarlyView.
Abstract The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology.
Julien Guizetti
wiley   +1 more source

Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis: a randomized controlled trial.

, 2012
BACKGROUND: Interferon-gamma (IFNγ) is of key importance in the immune response to Cryptococcus neoformans. Mortality related to cryptococcal meningitis remains high, and novel treatment strategies are needed.
Bekker, Linda-Gail, Bicanic, Tihana, Harrison, Thomas S, Jarvis, Joseph N, Meintjes, Graeme, Rebe, Kevin, Schutz, Charlotte, Williams, Anthony, Williams, Gertrude Ntombomzi, Wood, Robin   +9 more
core   +1 more source

Plasmodium falciparum histidine-rich protein II compromises brain endothelial barriers and may promote cerebral malaria pathogenesis [PDF]

, 2016
Cerebral malaria (CM) is a disease of the vascular endothelium caused by Plasmodium falciparum. It is characterized by parasite sequestration, inflammatory cytokine production, and vascular leakage. A distinguishing feature of P.
Daniels, Brian P, Diamond, Michael S, Goldberg, Daniel E, Klein, Robyn S, Oskman, Anna, Pal, Priya   +5 more
core   +3 more sources

Artificial intelligence‐powered microscopy: Transforming the landscape of parasitology

Journal of Microscopy, EarlyView.
Abstract Microscopy and image analysis play a vital role in parasitology research; they are critical for identifying parasitic organisms and elucidating their complex life cycles. Despite major advancements in imaging and analysis, several challenges remain. These include the integration of interdisciplinary data; information derived from various model
Mariana De Niz, Sara Silva Pereira, David Kirchenbuechler, Leandro Lemgruber, Constadina Arvanitis   +4 more
wiley   +1 more source

Severe neurological sequelae and behaviour problems after cerebral malaria in Ugandan children [PDF]

, 2010
BACKGROUND: Cerebral malaria is the most severe neurological complication of falciparum malaria and a leading cause of death and neuro-disability in sub-Saharan Africa.
Angelina Kakooza-Mwesige, Christine Mugasha, Grace Mirembe, Joshua Tugumisirize, Justus Byarugaba, Richard Idro, Stephen Balyejjussa   +6 more
core   +2 more sources