Results 91 to 100 of about 270,836 (221)
Molecular Microbiology, Volume 123, Issue 4, Page 330-343, April 2025.In silico workflow for selection of genes targeted in this study. We have identified a number of proteins involved in host cell modification by malaria parasites. Furthermore, we highlight a number of genes that appear to be essential for blood‐stage survival of these parasites.
Nina Küster +4 more
wiley +1 more source
Molecular Microbiology, EarlyView.Biochemical data on the isolated Na+/H+‐exchanging ATPase, PfATP4, from the malaria parasite are missing. Here, we expressed and purified the nucleotide and phosphate binding domains as a soluble protein and identified key residues by enzymatic characterization of generated point mutants.
Timo Beyer +3 more
wiley +1 more source
Rising report of Plasmodium vivax in sub-Saharan Africa: Implications for malaria elimination agenda
Scientific African, 2020 Plasmodium vivax and P. falciparum are the most important human malaria species. P. falciparum is considered the most virulent and widespread species in sub-Saharan Africa.
Mary Aigbiremo Oboh +5 more
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BMC Medicine, 2014 BackgroundAn understanding of the mechanisms mediating protective immunity against malaria in humans is currently lacking, but critically important to advance the development of highly efficacious vaccines. Antibodies play a key role in acquired immunity,
F. Osier +11 more
semanticscholar +1 more source
Vaccine Adjuvants in the Immunocompromised Host: Science, Safety, and Efficacy
Transplant Infectious Disease, EarlyView.ABSTRACT Vaccine adjuvants are essential for enhancing immune responses to vaccines, particularly in immunocompromised populations who typically demonstrate suboptimal responses to standard vaccination. This narrative review evaluates the safety and efficacy of approved and candidate adjuvants in immunocompromised hosts, with emphasis on solid organ ...
Haya Hayek +8 more
wiley +1 more source
F1000Research, 2018 Background: Malaria continues to present a global health threat; the World Health Organization (WHO) reported 214 million cases of malaria by the year 2015 with a death rate of 438000.
Walaa Salah Abdulla Mohammed +3 more
doaj +1 more source
Spiroindolone KAE609 for falciparum and vivax malaria.
New England Journal of Medicine, 2014 BACKGROUND KAE609 (cipargamin; formerly NITD609, Novartis Institute for Tropical Diseases) is a new synthetic antimalarial spiroindolone analogue with potent, dose-dependent antimalarial activity against asexual and sexual stages of Plasmodium falciparum.
N. White +8 more
semanticscholar +1 more source
Tropical Medicine &International Health, EarlyView.Abstract Objectives Prior to 2017, Odisha accounted for 50% of all Plasmodium falciparum cases in India. The ‘National Strategic Plan’ for malaria elimination had distributed 11.3 million insecticidal treated nets (ITNs) to 23 million individuals in Odisha's 17 malaria‐endemic districts by 2017.
A. N. Shriram +6 more
wiley +1 more source
Transfusion, Volume 65, Issue 4, Page 767-772, April 2025.Abstract Introduction/Background Platelet membrane glycoproteins (GPs) serve several functions, the most significant of which is their role in primary hemostasis. Among these, GP IIb/IIIa is the primary fibrinogen receptor and is essential for platelet aggregation.
Tro Sekayan +8 more
wiley +1 more source
CLINICAL PRESENTATION AND OUTCOME OF 100 CASES OF FALCIPARUM MALARIA
Khyber Medical University Journal, 2012 Objective: To evaluate the clinical presentation and outcome of Falciparum malaria in 100 hospitalized patients. Methodology: This hospital based descriptive study was conducted at Department of Medicine, Khyber Teaching Hospital, Peshawar from January ...
Iqbal Haider +6 more
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