Results 91 to 100 of about 137,891 (245)

Anaemia of Plasmodium falciparum malaria

Baillière's Clinical Haematology, 1992
The pathophysiology of the anaemia of falciparum malaria is both complex and multifactorial, and results in a condition which is a major cause of mortality and morbidity in patients, especially children and pregnant women, living in malarial endemic areas.
Phillips, R, Pasvol, G
openaire   +3 more sources

Population pharmacokinetics of artemether–lumefantrine plus amodiaquine in patients with uncomplicated Plasmodium falciparum malaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based combination therapies, TACT), consisting of two partner drugs with different mechanisms of action and similar ...
Junjie Ding, Richard M. Hoglund, Rob W. van der Pluijm, James J. Callery, Thomas J. Peto, Rupam Tripura, Sukanta Das, Nguyễn Hoàng Châu, Cholrawee Promnarate, Mavuto Mukaka, Lek Dysoley, Caterina Fanello, Marie A. Onyamboko, Anupkumar R. Anvikar, Mayfong Mayxay, Frank Smithuis, Lorenz von Seidlein, Mehul Dhorda, Chanaki Amaratunga, M. Abul Faiz, Ho Dang Trung Nghia, Nicholas J. White, Nicholas P. J. Day, Arjen M. Dondorp, Joel Tarning   +24 more
wiley   +1 more source

Whole genome sequencing and microsatellite analysis of the Plasmodium falciparum E5 NF54 strain show that the var, rifin and stevor gene families follow Mendelian inheritance [PDF]

, 2018
Background: Plasmodium falciparum exhibits a high degree of inter-isolate genetic diversity in its variant surface antigen (VSA) families: P. falciparum erythrocyte membrane protein 1, repetitive interspersed family (RIFIN) and subtelomeric variable ...
Bruske, Ellen, Frank, Matthias, Otto, Thomas D.   +2 more
core   +5 more sources

Tandem Mass Spectrometry and Bio‐Guided Isolation of Secondary Metabolites With Antiplasmodial Activity From Dalbergia miscolobium Bark

Chemistry &Biodiversity, EarlyView.
ABSTRACT Strategies have been employed to address antimalarial drug resistance, including the exploration of new therapeutic targets. In this study, the stem bark of Dalbergia miscolobium was investigated using in vitro assays against Plasmodium falciparum and pyruvate kinase II (PyrKII), an essential enzyme for parasite development.
Thais Bertolino Vieira Dantas, Igor M. R. Moura, Romário Pereira da Costa, Guilherme Eduardo de Souza, Richele Priscila Severino, Hélder Nagai Consolaro, Luis Felipe de Oliveira, Vinicius Bonatto, Quezia Bezerra Cass, Rafael V. C. Guido, Lorena Ramos Freitas de Sousa   +10 more
wiley   +1 more source

Comparative assessment of clinic-laboratory profile of different species of severe malaria in a tertiary care institute in southern India

Journal of Vector Borne Diseases, 2019
Background & objectives: Majority of the studies on severe malaria in India have concentrated on falciparum and have been done in northern part.
Thomas Kuncheria, Nithyananda K Chowta, Deepak Madi, Mukta N Chowta, A Basavaprabhu   +4 more
doaj  

Inactivation of Plasmodium falciparum in whole blood by riboflavin plus irradiation.

, 2013
BACKGROUND: Malaria parasites are frequently transmitted by unscreened blood transfusions in Africa. Pathogen reduction methods in whole blood would thus greatly improve blood safety.
Allain, Jean-Pierre, Atwal, Sharan, Dinko, Bismarck, El Chaar, Mira, Freimanis, Graham L, Sutherland, Colin J   +5 more
core   +1 more source

An evolutionary perspective on the kinome of malaria parasites [PDF]

, 2012
Malaria parasites belong to an ancient lineage that diverged very early from the main branch of eukaryotes. The approximately 90-member plasmodial kinome includes a majority of eukaryotic protein kinases that clearly cluster within the AGC, CMGC, TKL ...
Andrew B. Tobin, Carvalho T. G., Christian Doerig, Eric Talevich, Natarajan Kannan, Wells T. N., Wilson R. J.   +6 more
core   +1 more source

Substitution of CH3 by CH2F in 2‐Methylerythritol Cyclodiphosphate Triggers Potent Inhibition of IspG with Concomitant Fluoride Ion Expulsion

Chemistry – A European Journal, EarlyView.
The fluoromethyl analogue of MEcPP was identified as a very potent inhibitor of the oxygen‐sensitive [4Fe‐4S] metalloenzyme IspG. In the course of the IspG‐catalyzed transformation, this novel compound undergoes fluoride elimination, offering additional evidence for the involvement of a carbanionic intermediate in the mechanism of this enzyme ...
Clea Witjaksono, Vivien Herrscher, Hannah Jobelius, Nathan Noël, Fabien Massicot, Jean‐Luc Vasse, Jean‐Bernard Behr, Myriam Seemann   +7 more
wiley   +1 more source

Plasma mEV levels in Ghanain malaria patients with low parasitaemia are higher than those of healthy controls, raising the potential for parasite markers in mEVs as diagnostic targets [PDF]

, 2019
© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.
Antwi-Baffour, Samuel, Inal, Jameel, Jorfi, Samireh, Lange, Sigrun, Malibha-Pinchbeck, Memory, Stratton, Dan   +5 more
core   +5 more sources

AgamOBP1‐Directed Discovery of Repellents to Control the Spread of Mosquito‐Borne Diseases

ChemMedChem, EarlyView.
Toward the discovery of novel mosquito repellents, a library of potential binders of AgamOBP1 (secondary amines) generated from two amines and seven aldehydes was designed aiming to enable interactions with critical amino acids at the DEET‐site and to bridge the DEET‐ and Icaridin sIC‐binding pockets. 1H STD NMR spectroscopy in the presence of AgamOBP1
Evanthia Chazapi, Eftichia Kritsi, Constantinos Potamitis, Panagiota G. V. Liggri, Katerina E. Tsitsanou, Christina E. Drakou, Antonios Michaelakis, Dimitrios P. Papachristos, Spyros E. Zographos, Maria Zervou, Theodora Calogeropoulou   +10 more
wiley   +1 more source