Results 101 to 110 of about 270,836 (221)

A Novel Inhibitor against the Bromodomain Protein 1 of the Malaria Pathogen Plasmodium Falciparum

ChemMedChem, Volume 20, Issue 11, June 2, 2025.
This article presents the development of a first‐in‐class inhibitor targeting the bromodomain protein PfBDP1 in Plasmodium falciparum, the deadliest variant of the malaria‐causing Plasmodium parasites. Through structure‐based drug design, the inhibitor interactions were characterized via X‐ray crystallography and isothermal titration calorimetry ...
Marius Amann, Robin Warstat, Kay Kristin Rechten, Philip Theuer, Magdalena Schustereder, Sophie Clavey, Bernhard Breit, Oliver Einsle, Martin Hügle, Michaela Petter, Stefan Günther   +10 more
wiley   +1 more source

Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites

ChemMedChem, Volume 20, Issue 11, June 2, 2025.
Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert, Lucie Paloque, Jean‐Michel Augereau, Flore Nardella, Michel Nguyen, Bernard Meunier, Françoise Benoit‐Vical   +6 more
wiley   +1 more source

Falciparum malaria-induced acute pancreatitis

IDCases, 2020
Falciparum malaria is one of the most common causes of acute febrile illness in India and frequently presents as severe malaria also known as complicated malaria or cerebral malaria with associated multiple organ failure.
Shankar Roy, Ashwin Parchani, Samaksh Sharma, Mohan S, Venkatesh S. Pai   +4 more
doaj  

Molecular characterization of a synthetic neutralizing antibody targeting p67 of Theileria parva

Protein Science, Volume 34, Issue 6, June 2025.
Abstract The Theileria parva sporozoite surface antigen p67 is a target of the bovine humoral immune response that generates antibodies capable of providing protection against subsequent infection. As a result, p67 has been the subject of efforts aimed at the development of an anti‐sporozoite subunit vaccine.
Shane Miersch, Alex U. Singer, Chao Chen, Fred Fellouse, Anupriya Gopalsamy, Luciano Silva e Costa, Anna Lacasta, Hannah Chege, Naomi Chege, Vishvanath Nene, Sachdev S. Sidhu   +10 more
wiley   +1 more source

Mediation of the effect of malaria in pregnancy on stillbirth and neonatal death in an area of low transmission: observational data analysis

BMC Medicine, 2017
Background Malaria in pregnancy is preventable and contributes significantly to the estimated 5.5 million stillbirths and neonatal deaths that occur annually.
Kerryn A. Moore, Freya J. I. Fowkes, Jacher Wiladphaingern, Nan San Wai, Moo Kho Paw, Mupawjay Pimanpanarak, Verena I. Carrara, Jathee Raksuansak, Julie A. Simpson, Nicholas J. White, François Nosten, Rose McGready   +11 more
doaj   +1 more source

Enhancing schistosomiasis drug discovery approaches with optimized proteasome substrates

Protein Science, Volume 34, Issue 6, June 2025.
Abstract Schistosomiasis, a neglected tropical disease infecting over 200 million people globally, has limited therapeutic options. The 20S proteasome is a validated drug target for many parasitic infections, including those caused by Plasmodium and Leishmania, and we have previously demonstrated antischistosomal activity with inhibitors targeting ...
Elany B. Silva, Zhenze Jiang, Chenxi Liu, Pavla Fajtová, Thaiz R. Teixeira, Giovana de Castro Fiorini Maia, Lawrence J. Liu, Nelly El‐Sakkary, Danielle E. Skinner, Ali Syed, Steven C Wang, Conor R. Caffrey, Anthony J. O'Donoghue   +12 more
wiley   +1 more source

Procalcitonin as a biomarker for severe Plasmodium falciparum disease: a critical appraisal of a semi-quantitative point-of-care test in a cohort of travellers with imported malaria

Malaria Journal, 2009
Background Imported malaria occurs as a relatively rare event in developed countries. As a consequence, most clinicians have little experience in making clinical assessments of disease severity and decisions regarding the need for parenteral therapy or ...
Petit Pieter, Bosmans-Timmerarends Hanna, Burgerhart Jan-Steven, Hesselink Dennis A, van Genderen Perry JJ   +4 more
doaj   +1 more source

Land Use Change and Infectious Disease Emergence

Reviews of Geophysics, Volume 63, Issue 2, June 2025.
Abstract Major infectious diseases threatening human health are transmitted to people from animals or by arthropod vectors such as insects. In recent decades, disease outbreaks have become more common, especially in tropical regions, including new and emerging infections that were previously undetected or unknown. Even though there is growing awareness
M. Cristina Rulli, Paolo D’Odorico, Nikolas Galli, Reju S. John, Renata L. Muylaert, Monia Santini, David T. S. Hayman   +6 more
wiley   +1 more source

Association of CD40L gene polymorphism with severe Plasmodium falciparum malaria in Indian population

Journal of Vector Borne Diseases, 2017
Background & objectives: Many host genetic factors are associated with the disease severity and fatal outcome of falciparum malaria. CD40L gene has been found to be one of the most important factors associated with malaria in African countries.
Prasanta Purohit, Pradeep Kumar Mohanty, Siris Patel, Padmalaya Das, Kishalaya Das, Jogeswar Panigrahi   +5 more
doaj  

PENGGUNAAN METODE ACTIVE CONTOUR UNTUK SEGMENTASI PARASIT MALARIA PLASMODIUM FALCIPARUM

Simetris: Jurnal Teknik Mesin, Elektro dan Ilmu Komputer, 2015
ABSTRAK Plasmodium falciparum merupakan penyebab malaria tropika atau malaria falciparum. Spesies ini paling berbahaya dibandingkan keempat spesies lainnya karena dapat menyebabkan komplikasi malaria serebral.
Endi Permata
doaj   +1 more source