Angewandte Chemie, EarlyView.In this study, we repurposed human Aurora kinase‐specific inhibitors to identify potential antimalarial agents. Two inhibitors, hesperadin and TAE684, exhibited sub‐micromolar activity across multiple parasite stages, with hesperadin demonstrating significant potency and selectivity by specifically targeting PfArk1.
Henrico Langeveld +23 more
wiley +2 more sources
Nephropathy in falciparum malaria
Kidney International, 1988 Observation chez un homme de 33 ans. Traitement par quinine en intraveineuse et guerison 32 jours plus tard avec un taux serique de creatinine a 1,1 mg ...
openaire +2 more sources
Rising report of Plasmodium vivax in sub-Saharan Africa: Implications for malaria elimination agenda
Scientific African, 2020 Plasmodium vivax and P. falciparum are the most important human malaria species. P. falciparum is considered the most virulent and widespread species in sub-Saharan Africa.
Mary Aigbiremo Oboh +5 more
doaj +1 more source
Community-based Approach to Intermittent Preventive Treatment for Malaria in Pregnancy in Kisumu, Kenya [PDF]
, 2014 Malaria in pregnancy (MiP) is a significant contributor to maternal and newborn morbidity and mortality. In malaria-endemic countries, especially those in tropical areas of Africa where there is intense transmission of Plasmodium falciparum (P ...
core
Ecological immunology of mosquito-malaria interactions: Of non-natural versus natural model systems and their inferences [PDF]
, 2009 There has been a recent shift in the literature on mosquito/Plasmodium interactions with an increasingly large number of theoretical and experimental studies focusing on their population biology and evolutionary processes.
Tripet, F
core +1 more source
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
Non-falciparum malaria infections in Uganda, does it matter? A review of the published literature
Malaria JournalBackground Plasmodium falciparum is the dominant malaria species in the sub-Saharan Africa and the main cause of severe disease and death. Notwithstanding, severe malaria and death due to non-falciparum infections have been reported, but at much lower ...
Mansour Ranjbar +1 more
doaj +1 more source
HIV Malaria Co-Infection Is Associated with Atypical Memory B Cell Expansion and a Reduced Antibody Response to a Broad Array of Plasmodium falciparum Antigens in Rwandan Adults. [PDF]
PLoS ONE, 2015 HIV infected individuals in malaria endemic areas experience more frequent and severe malaria episodes compared to non HIV infected. This clinical observation has been linked to a deficiency in antibody responses to Plasmodium falciparum antigens ...
Krishanthi S Subramaniam +9 more
doaj +1 more source
Genetic Manipulation of Non-Falciparum Human Malaria Parasites
Frontiers in Cellular and Infection Microbiology, 2021 The development of genetic manipulation of Plasmodium falciparum in the 1980s was key to study malaria biology. Genetically modified parasites have been used to study several aspects of the disease, such as red blood cell invasion, drug resistance ...
Taís Baruel Vieira +2 more
doaj +1 more source
Death rates from malaria epidemics, Burundi and Ethiopia. [PDF]
, 2007 Death rates exceeded emergency thresholds at 4 sites during epidemics of Plasmodium falciparum malaria in Burundi (2000-2001) and in Ethiopia (2003-2004).
Ahoua, L +9 more
core +3 more sources