The Origins of African Plasmodium vivax; Insights from Mitochondrial Genome Sequencing [PDF]
Plasmodium vivax, the second most prevalent of the human malaria parasites, is estimated to affect 75 million people annually. It is very rare, however, in west and central Africa, due to the high prevalence of the Duffy negative phenotype in the human ...
Kaneko, Akira +40 more
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Growing evidence of Plasmodium vivax across malaria-endemic Africa. [PDF]
Effective malaria control strategies require an accurate understanding of the epidemiology of locally transmitted Plasmodium species. Compared to Plasmodium falciparum infection, Plasmodium vivax has a lower asexual parasitaemia, forms dormant liver ...
Katherine A Twohig +8 more
doaj +1 more source
Efficacy and safety of dihydroartemisinin-piperaquine for treatment of Plasmodium vivax malaria in endemic countries: meta-analysis of randomized controlled studies [PDF]
Background: This study aimed to synthesize available evidence on the efficacy of dihydroartemisinin-piperaquine (DHP) in treating uncomplicated Plasmodium vivax malaria in people living in endemic countries.
Cho Naing (492196) +27 more
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Plasmodium vivax populations are more genetically diverse and less structured than sympatric Plasmodium falciparum populations [PDF]
The human malaria parasite, Plasmodium vivax, is proving more difficult to control and eliminate than Plasmodium falciparum in areas of co-transmission.
Ingrid Felger (92160) +44 more
core +1 more source
Malaria Policy Advisory Committee to the WHO : conclusions and recommendations of seventh biannual meeting (March 2015) [PDF]
The Malaria Policy Advisory Committee to the World Health Organization held its seventh meeting in Geneva, Switzerland from 5 to 7 March 2015. This article provides a summary of the discussions, conclusions and meeting recommendations.
WHO Malaria Policy Advisory Committee and Secretariat, +1 more
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A large Plasmodium vivax reservoir and little population structure in the South Pacific [PDF]
The importance of Plasmodium vivax in malaria elimination is increasingly being recognized, yet little is known about its population size and population genetic structure in the South Pacific, an area that is the focus of intensified malaria control.; We
Timinao Lincoln +34 more
core +1 more source
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood +7 more
wiley +1 more source
Plasmodium vivax antigen discovery based on alpha-helical coiled coil protein motif [PDF]
Protein α-helical coiled coil structures that elicit antibody responses, which block critical functions of medically important microorganisms, represent a means for vaccine development.
Kajava, Andrey V. +32 more
core +2 more sources
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
Molecular epidemiology and population genetics of "Plasmodium vivax" in Papua New Guinea [PDF]
: In recent years a new focus has been put on malaria, and elimination and eradication of this disease has been brought back to the agenda. While Plasmodium falciparum causes most of the disease in Africa, P.
Köpfli, Cristian
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