Results 51 to 60 of about 192,372 (174)

Apigenin Protects Hypertensive Intracerebral Hemorrhage by Regulating Trx1 Through Binding to PRDX2

Phytotherapy Research, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) remains the most severe stroke subtype with high mortality and disability rates. Although apigenin has shown cerebroprotective potential in preclinical studies, its mechanism of action, particularly in hypertensive ICH, remains poorly understood.
Hao‐chen Xu, Ming Liu, Ying‐ying Sun, Jie‐Dan Ping, Qing‐hua Cui, Jing‐zhou Chen, Hao Li   +6 more
wiley   +1 more source

A high force of Plasmodium vivax blood-stage infection drives the rapid acquisition of immunity in Papua New Guinean children [PDF]

, 2013
When both parasite species are co-endemic, Plasmodium vivax incidence peaks in younger children compared to P. falciparum. To identify differences in the number of blood stage infections of these species and its potential link to acquisition of immunity,
Speed, Terence P., Ingrid Felger (92160), Kiniboro, B, Mueller Ivo, Kathryn L Colborn, Koepfli, Cristian, Terence P. Speed (132229), Speed Terence P., Koepfli, C, Cristian Koepfli, Felger Ingrid, Felger, Ingrid, Kiniboro, Benson, Terence P Speed, Kiniboro Benson, Ingrid Felger, Peter M. Siba (136849), Ivo Mueller (46609), Felger, I, Enmoore Lin, Lin Enmoore, Mueller, Ivo, Benson Kiniboro (191309), Ivo Mueller, Enmoore Lin (137888), Koepfli Cristian, Lin, Enmoore, Lin, E, Kathryn L. Colborn (454997), Colborn Kathryn L., Siba Peter M., Speed, TP, Mueller, I, Colborn, Kathryn L., Siba, PM, Siba, Peter M., Colborn, KL, Peter M Siba, Cristian Koepfli (191306), Benson Kiniboro   +39 more
core   +2 more sources

School-based surveys of malaria in Oromia Regional State, Ethiopia: a rapid survey method for malaria in low transmission settings. [PDF]

, 2011
BACKGROUND: In Ethiopia, malaria transmission is seasonal and unstable, with both Plasmodium falciparum and Plasmodium vivax endemic. Such spatial and temporal clustering of malaria only serves to underscore the importance of regularly collecting up-to ...
Pullan, Rachel L, Yadeta, Damtew, Reithinger Richard, Brooker Simon, Kolaczinski, Jan H, Brooker, Simon, Kolaczinski Jan H, Ashton, Ruth A, Simon Brooker, Reithinger, Richard, Ashton Ruth A, Jan H Kolaczinski, Tesfaye Gezahegn, Ruth A Ashton, Pullan Rachel L, Kefyalew, Takele, Gezahegn Tesfaye, Richard Reithinger, Tesfaye, Gezahegn, Yadeta Damtew, Kefyalew Takele, Takele Kefyalew, Damtew Yadeta, Rachel L Pullan   +23 more
core   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Long-lived antibody and B Cell memory responses to the human malaria parasites, Plasmodium falciparum and Plasmodium vivax. [PDF]

, 2010
Antibodies constitute a critical component of the naturally acquired immunity that develops following frequent exposure to malaria. However, specific antibody titres have been reported to decline rapidly in the absence of reinfection, supporting the ...
Thaikla, Kanitta, Riley, Eleanor M, Julius Clemence R Hafalla, Cook Jackie, Lucy C Okell, Eleanor M Riley, Suphavilai Chaisuree, Lucy C. Okell, Witaya Liewsaree, Okell, Lucy C, Liewsaree, W, Corran Patrick H., Hafalla Julius Clemence R., Cook, Jackie, Corran, Patrick H, Kanitta Thaikla, Cook, J, Patrick H. Corran, Hafalla, Julius Clemence R, Chaisuree Suphavilai, Wipasa, J, Suphavilai, C, Okell Lucy C., Riley Eleanor M., Jackie Cook, Wipasa Jiraprapa, Julius Clemence R. Hafalla, Liewsaree, Witaya, Suphavilai, Chaisuree, Thaikla, K, Eleanor M. Riley, Patrick H Corran, Hafalla, JC, Thaikla Kanitta, Wipasa, Jiraprapa, Okell, LC, Riley, EM, Corran, PH, Liewsaree Witaya, Jiraprapa Wipasa   +39 more
core   +2 more sources

Plasmodium falciparum Parasites With Histidine‐Rich Protein 2 (pfhrp2) and pfhrp3 Gene Deletions in Frontier Endemic Regions of Brazilian Amazon

Tropical Medicine &International Health, EarlyView.
ABSTRACT Studies reporting deletions of the pfhrp2 and pfhrp3 genes in P. falciparum populations in various malaria‐endemic countries, including countries bordering Brazil, are increasing. Individuals infected with P. falciparum carrying deletions of the pfhrp2/3 genes may yield false‐negative results in Rapid Diagnostic Tests (RDTs) based on the ...
Jéssica de Oliveira Bonsanto Gonçalves, Simone da Silva Santos, Rodrigo Medeiros Martorano, Jaime Louzada, Victoria Martins Roque Almeida, Lucas Rego Viana, Josely Oliveira Ferreira, Anielle Pina Costa, André Siqueira, Martha Cecília Suárez‐Mutis   +9 more
wiley   +1 more source

Malaria : einst vergessen, dereinst zu vergessen? [PDF]

, 2011
Quintessenz: Malaria ist während der letzten zehn Jahre dank breiter Anwendung von Präventionsmassnahmen (mit Insektiziden imprägnierte Moskitonetze, Sprays in Wohnungen) und wirksamer Behandlung in über 50 Ländern um fast die Hälfte zurückgegangen.
B Genton, D'Acremont, V., V DAcremont, Genton, B.   +3 more
core   +1 more source

Donor management implications for high‐sensitivity detection of low‐level malaria parasitemia in blood donor screening

Transfusion, EarlyView.
Abstract Introduction Transfusion‐transmitted malaria can occur when donors have unrecognized asymptomatic infection with submicroscopic parasitemia, highlighting the need to detect low‐level parasitemia in blood donor screening. However, these highly sensitive blood donor testing algorithms may refer donors to clinicians who use diagnostic algorithms ...
Carmen L. Charlton, Valerie Conrod, Dilini Kumaran, Craig Jenkins, Sandy Shokoples, LeeAnn Turnbull, Ruwandi Kariyawasam, Chantale Pambrun, Steven J. Drews   +8 more
wiley   +1 more source

Significant geographical differences in prevalence of mutations associated with Plasmodium falciparum and Plasmodium vivax drug resistance in two regions from Papua New Guinea [PDF]

, 2015
Drug resistance remains a major obstacle to malaria treatment and control. It can arise and spread rapidly, and vary substantially even at sub-national level.
Jonah Iga (175169), Barnadas, Céline, Zimmerman, Peter A., Timinao, Lincoln, Koepfli, Cristian, Peter Siba (112258), Sarah Javati (464175), John Reeder (3400391), Kiniboro, Benson, Ivo Mueller (46609), Senn, Nicolas, Javati, Sarah, Iga, Jonah, Malau, Elisheba, Rare, Lawrence, Mueller, Ivo, Elisheba Malau (3518690), Benson Kiniboro (191309), Lincoln Timinao (423264), CĂŠline Barnadas (3506528), Siba, Peter, Timothy Davis (268628), Harin Karunajeewa (336719), Davis, Timothy M., Leanne Robinson (175144), Reeder, John C., Nicolas Senn (137902), Peter Zimmerman (34037), Robinson, Leanne J., Siba, Peter M., Karunajeewa, Harin, Cristian Koepfli (191306), Lawrence Rare (377507)   +32 more
core   +1 more source

Budget impact of implementing universal Plasmodium NAT screening in the blood transfusion system in the US

Transfusion, EarlyView.
Abstract Background Blood donor deferral for malaria risk relies exclusively on responses to self‐reported questionnaires. This study evaluated the economic impact of introducing Plasmodium nucleic acid testing (NAT) as a universal screening strategy in the United States.
Cristina Coll‐Ortega, Elisabet Viayna, Jiani Zhou, Susan L. Stramer   +3 more
wiley   +1 more source