Results 41 to 50 of about 976,240 (379)

Rational use of antibiotics by community health workers and caregivers for children with suspected pneumonia in Zambia: a cross-sectional mixed methods study

BMC Public Health, 2016
Background Antibiotic resistance is an issue of growing global concern. One key strategy to minimise further development of resistance is the rational use of antibiotics, by providers and patients alike. Through integrated community case management (iCCM)
Kirstie Graham, Chomba Sinyangwe, Sarala Nicholas, Rebecca King, Samuel Mukupa, Karin Källander, Helen Counihan, Mark Montague, James Tibenderana, Prudence Hamade   +9 more
doaj   +1 more source

A feasibility study to assess non-clinical community health workers’ capacity to use simplified protocols and tools to treat severe acute malnutrition in Niger state Nigeria

BMC Health Services Research, 2021
Background Severe acute malnutrition (SAM) is a major determinant of childhood mortality and morbidity. Although integrated community case management (iCCM) of childhood illnesses is a strategy for increasing access to life-saving treatment, malnutrition
Olatunde Adesoro, Olusola Oresanya, Helen Counihan, Prudence Hamade, Dare Eguavon, Chika Emebo, Bethany Marron, Naoko Kozuki, Amina Isah, Patrick Gimba, Chris Osa Isokpunwu, Kolawole Maxwell, James K. Tibenderana   +12 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Adherence to referral advice and its associated factors among community drug distributors and caregiver during SMC implementation in nine states

Malaria Journal
Background Malaria is a global public health problem that disproportionately affects under-five children in poor resource countries. Nigeria accounted for the highest burden of malaria in Western Africa.
Taiwo Ibinaiye, Ayodeji Balogun, Emmanuel Salifu, Benjamin Amao, Emmanuel Musa, Daniel Emeto, Samuel Ayoola, Usman Hussaini, Chibuzo Oguoma, Abdullahi Abdulrazak, Zechariah Maleeks, Olabisi Ogunmola, Olusola Oresanya, Kunle Rotimi   +13 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Urban–rural differences in seasonal malaria chemoprevention coverage and characteristics of target populations in nine states of Nigeria: a comparative cross-sectional study

Malaria Journal
Background Differences between urban and rural contexts in terms of sociodemographic characteristics, geographical features and risk perceptions may lead to disparities in coverage and related outcomes of community-based preventive interventions, such as
Taiwo Ibinaiye, Kunle Rotimi, Ayodeji Balogun, Adaeze Aidenagbon, Chibuzo Oguoma, Kevin Baker, Olabisi Ogunmola, Olusola Oresanya, Christian Rassi, Chuks Nnaji   +9 more
doaj   +1 more source

Developing Ontology Support for Human Malaria Control Initiatives [PDF]

, 2009
Malaria is one of the most common infectious diseases and an enormous public health problem in Sub-Sahara Africa, Asia and parts of America. In this paper, we discuss the development of the Human Malaria Control Ontology (HMCO) which contains general ...
Daramola Olawande, Fatumo Segun
core   +1 more source

Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care. [PDF]

, 2011
BACKGROUND\ud \ud An effective malaria vaccine, deployed in conjunction with other malaria interventions, is likely to substantially reduce the malaria burden. Efficacy against severe malaria will be a key driver for decisions on implementation.
Amanda Leach, Brian Greenwood, Daniel Ansong, David Schellenberg, Jahit Sacarlal, Jennifer Evans, Johan Vekemans, Kevin Marsh, Kwaku Asante, Mary J Hamel, Nahya Salim, null null, Patricia Njuguna, Philip Bejon, Portia Kamthunzi, Samwel Gesase, Solange Soulanoudjingar, Walter Otieno, William Kabore   +18 more
core   +4 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Impact of seasonal malaria chemoprevention: a plausibility evaluation of routine data from health facilities in three implementing states in Nigeria

Malaria Journal
Background Seasonal malaria chemoprevention (SMC) has been recommended by the World Health Organization since 2012 for eligible children in areas where malaria transmission is highly seasonal and intense. By 2024, SMC had been successfully implemented in
Ebenezer C. Ikechukwu, Ekechi Okereke, Olabisi Ogunmola, Jennifer Chukwumerije, Daniel Emeto, Emmanuel Salifu, Ayodeji Balogun, Chibuzo Oguoma, Emmanuel Shekarau, Nnenna Ogbulafor, Eoin Cassidy, Christian Rassi, Olusola Oresanya, Chukwudi A. Nnaji   +13 more
doaj   +1 more source