Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Selective targeting of <i>Plasmodium falciparum</i> hexose transporter by phytochemical Ginsenoside Rg1 disrupts glucose metabolism and blocks development of parasite. [PDF]
Shafi S +6 more
europepmc +1 more source
Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi +4 more
wiley +1 more source
Mixed Plasmodium vivax and falciparum Malaria in a Young Infant: The Critical Role of Peripheral Smears in an Endemic Region. [PDF]
Rizvi A +4 more
europepmc +1 more source
ABSTRACT Climate change is having significant demographic and health impacts on human populations around the world. There is growing empirical evidence about the impacts of climate variability and change on population health, but this work has focused disproportionately on children and aggregate indicators of weight and (or) height.
Alfredo J. Rojas Jr +3 more
wiley +1 more source
Reevaluating malaria severity metrics: insights from PfHRP2-derived biomass estimates in Ghanaian children. [PDF]
Konadu EA +9 more
europepmc +1 more source
The Baboon as a Model to Study Human Health and Complex Disease
Baboons remain underappreciated as models of human biology and disease offering a distinct combination of biological and practical properties. In this review, we evaluate the baboon as a model for human complex diseases and make the case for broader use of baboons in translational research.
Brittany Hazzard, Yoav Gilad
wiley +1 more source
Design, Synthesis, and Evaluation of New 1,4‐Naphthoquinone‐1,2,3‐triazoles as Antimalarial Agents
Compound 9g, a 1,4‐naphthoquinone‐1,2,3‐triazole derivative, exhibited potent activity against P. falciparum 3D7 and in silico analysis revealed strong interactions with 1J3 and 1LDG targets, while MD simulations confirmed the stability of the ligand‐3FGO complex.
Lina Rezainia +13 more
wiley +1 more source
Re-evaluating malarial retinopathy to improve its diagnostic accuracy in paediatric cerebral malaria: A retrospective study. [PDF]
Wilson KJ +8 more
europepmc +1 more source
Green microwave‐ and ultrasound‐assisted synthesis enables the rapid, sustainable preparation of quinoline‐based anticancer agents with improved reaction efficiency, higher yields, and enhanced biological activity. ABSTRACT Quinoline derivatives represent a privileged class of heterocyclic compounds with remarkable structural diversity and broad ...
Rohit Pal +5 more
wiley +1 more source

