Results 11 to 20 of about 5,753 (147)

Oral melatonin improves the detection of parasitemia in malaria

Journal of Infection in Developing Countries, 2020
Introduction: Malaria is a growing global threat and a major cause of mortality in the tropics. The gold standard diagnosis is peripheral blood smear examination.
Chandan Kumar Kedarisetty, B Laksminarayana Samaga, Sudha Vidyasagar, Jayanthi Venkataraman   +3 more
doaj   +1 more source

Biological activities of nitidine, a potential anti-malarial lead compound

Malaria Journal, 2012
Background Nitidine is thought to be the main active ingredient in several traditional anti-malarial remedies used in different parts of the world. The widespread use of these therapies stresses the importance of studying this molecule in the context of ...
Bouquet Jérome, Rivaud Marion, Chevalley Séverine, Deharo Eric, Jullian Valérie, Valentin Alexis   +5 more
doaj   +1 more source

Discovery of potent, novel, non-toxic anti-malarial compounds via quantum modelling, virtual screening and in vitro experimental validation

Malaria Journal, 2011
Background Developing resistance towards existing anti-malarial therapies emphasize the urgent need for new therapeutic options. Additionally, many malaria drugs in use today have high toxicity and low therapeutic indices.
Kaludov Nikola, Sullivan David J, Martinov Martin N   +2 more
doaj   +1 more source

Clinical recovery of Macaca fascicularis infected with Plasmodium knowlesi

Malaria Journal, 2021
Background Kra monkeys (Macaca fascicularis), a natural host of Plasmodium knowlesi, control parasitaemia caused by this parasite species and escape death without treatment.
Mariko S. Peterson, Chester J. Joyner, Jessica A. Brady, Jennifer S. Wood, Monica Cabrera-Mora, Celia L. Saney, Luis L. Fonseca, Wayne T. Cheng, Jianlin Jiang, Stacey A. Lapp, Stephanie R. Soderberg, Mustafa V. Nural, Jay C. Humphrey, Allison Hankus, Deepa Machiah, Ebru Karpuzoglu, Jeremy D. DeBarry, MaHPIC-Consortium, Rabindra Tirouvanziam, Jessica C. Kissinger, Alberto Moreno, Sanjeev Gumber, Eberhard O. Voit, Juan B. Gutiérrez, Regina Joice Cordy, Mary R. Galinski   +25 more
doaj   +1 more source

Phytoconstituents Assisted Biofabrication of Copper Oxide Nanoparticles and Their Antiplasmodial, and Antilarval Efficacy: A Novel Approach for the Control of Parasites

Molecules, 2022
The present work aimed to biofabricate copper oxide nanoparticles (CuO NPs) using Tinospora cordifolia leaf extract. The biofabricated CuO NPs were treated against the malarial parasite of chloroquine-resistant Plasmodium falciparum (INDO) and the ...
Chidambaram Jayaseelan, Ahmed Abdulhaq, Chinnasamy Ragavendran, Syam Mohan   +3 more
doaj   +1 more source

Parasite genetic diversity reflects continued residual malaria transmission in Vhembe District, a hotspot in the Limpopo Province of South Africa

Malaria Journal, 2021
Background South Africa aims to eliminate malaria transmission by 2023. However, despite sustained vector control efforts and case management interventions, the Vhembe District remains a malaria transmission hotspot.
Hazel B. Gwarinda, Sofonias K. Tessema, Jaishree Raman, Bryan Greenhouse, Lyn-Marié Birkholtz   +4 more
doaj   +1 more source

Reactive, self-administered malaria treatment against asymptomatic malaria infection: results of a cluster randomized controlled trial in The Gambia

Malaria Journal, 2021
Background Selectively targeting and treating malaria-infected individuals may further decrease parasite carriage in low-burden settings. Using a trans-disciplinary approach, a reactive treatment strategy to reduce Plasmodium falciparum prevalence in ...
Joseph Okebe, Edgard Dabira, Fatou Jaiteh, Nuredin Mohammed, John Bradley, Ndey-Fatou Drammeh, Amadou Bah, Yoriko Masunaga, Jane Achan, Joan Muela Ribera, Shunmay Yeung, Julie Balen, Koen Peeters Grietens, Umberto D’Alessandro   +13 more
doaj   +1 more source

Association of Climatic Variability, Vector Population and Malarial Disease in District of Visakhapatnam, India: A Modeling and Prediction Analysis.

PLoS ONE, 2015
BackgroundMalarial incidence, severity, dynamics and distribution of malaria are strongly determined by climatic factors, i.e., temperature, precipitation, and relative humidity.
Ravi Chandra Pavan Kumar Srimath-Tirumula-Peddinti, Nageswara Rao Reddy Neelapu, Naresh Sidagam   +2 more
doaj   +1 more source

Blood shizonticidal activities of phenazines and naphthoquinoidal compounds against Plasmodium falciparum in vitro and in mice malaria studies

Memorias do Instituto Oswaldo Cruz, 2014
Due to the recent advances of atovaquone, a naphthoquinone, through clinical trials as treatment for malarial infection, 19 quinone derivatives with previously reported structures were also evaluated for blood schizonticide activity against the malaria ...
Nicolli Bellotti de Souza, Isabel M de Andrade, Paula F Carneiro, Guilherme AM Jardim, Isadora MM de Melo, Eufrânio N da Silva Júnior, Antoniana Ursine Krettli   +6 more
doaj   +1 more source

Spontaneous splenic rupture in Plasmodium knowlesi malaria

Malaria Journal, 2018
Background Plasmodium knowlesi, a malaria parasite typically found in long-tailed and pig-tailed macaques, is the most common cause of human malaria in Malaysian Borneo.
Chee Yik Chang, Wei Chieng Pui, Khamisah Abdul Kadir, Balbir Singh   +3 more
doaj   +1 more source