Results 91 to 100 of about 195,003 (295)

Differentiation of isomeric N-glycan structures by normal-phase liquid chromatography-MALDI-TOF/TOF tandem mass spectrometry

open access: yes, 2006
The detailed characterization of protein N-glycosylation is very demanding given the many different glycoforms and structural isomers that can exist on glycoproteins.
Adam, Alex   +4 more
core   +1 more source

Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria

open access: yesAdvanced Science, EarlyView.
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song   +9 more
wiley   +1 more source

Polyproline: A Synthetic Polypeptide With Unique Properties

open access: yesAngewandte Chemie, EarlyView.
Poly‐L‐proline is a unique polypeptide distinguished by its well‐defined secondary structures and unusual thermal behavior. This mini review highlights recent advances in the synthesis of poly‐L‐proline by N‐carboxyanhydride (NCA) polymerization, the formation of structurally defined architectures and nanostructures, and emerging strategies that ...
Rosanna Le Scouarnec   +3 more
wiley   +2 more sources

Development of a mass spectrometry diagnostic assay to monitor hepcidin levels in hemochromatosis patients [PDF]

open access: yes, 2010
Hepcidin has been identified as the principle regulatory peptide essential for iron homeostasis. Expression of this cysteine-rich peptide is up-regulated by inflammation and iron overload, whereas hypoxia, iron deficiency and erythropoiesis suppress ...
Gay, Choon Lin Melvin
core  

Rapid Exonuclease‐Based De Novo Sequencing Strategy for Long Oligonucleotides via Liquid‐Phase Ion Trap Coupled With Mass Spectrometry

open access: yesAdvanced Science, EarlyView.
A liquid‐phase ion trap (LPIT) coupled with ESI‐MS enables rapid, high‐fidelity de novo sequencing of long oligonucleotides in ∼30 min. By applying an electric field to dissociate metal adducts in solution, LPIT delivers clean spectra, superior mass accuracy, and full sequence coverage, surpassing MALDI‐TOF and LC‐MS.
Song Lu   +5 more
wiley   +1 more source

Algorithms for the analysis of MALDI peptide mass fingerprint spectra for proteomics [PDF]

open access: yes, 2005
In this study we present a simple algorithm which allows accurate estimates of the similarity between peptide fingerprint mass spectra from matrix assisted laser desorption/ionization (MALDI) spectrometers.
Monigatti, Flavio
core   +1 more source

MALDI-TOF/ MS analysis of differentially expressed serum protein normal and LF cases.

open access: yes, 2022
MALDI-TOF/ MS analysis of differentially expressed serum protein normal and LF cases.
Ayushi Mishra (13007295)   +4 more
core   +1 more source

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

open access: yesAdvanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen   +7 more
wiley   +1 more source

Biotin‐ and Chloroalkane‐Modified Nucleotides for Dual Display of Proteins on DNA Through Streptavidin and Halotag Binding

open access: yesAngewandte Chemie, EarlyView.
Modified 2’‐deoxy‐7‐deazaadenosine bearing a chlorohexyl moiety and 2’‐deoxycytidine nucleotides bearing biotin were used in the enzymatic synthesis of dually modified dsDNAs that served as scaffolds for display of halotag and monomeric streptavidin proteins.
Giammarco Liuni   +4 more
wiley   +2 more sources

Controlling Self‐Doping in Conjugated Polyelectrolyte Copolymers to Vary the Threshold Voltage in OECTs

open access: yesAdvanced Electronic Materials, EarlyView.
Two series of self‐doped conjugated polyelectrolytes are synthesized from a non‐self‐dopable building block 3MEEET and a self‐dopable building‐block 3HOT−[TMA+] or 3HOT−[SO3H] enabling precise control over the degree of self‐doping, which in turn directly governs the threshold voltage (VT) in OECTs over a wide range of 700 mV.
Julian Hungenberg   +7 more
wiley   +1 more source

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