Results 61 to 70 of about 195,003 (295)

MALDI-TOF database composition.

, 2018
Brucella strains used to construct the MALDI-TOF database. Further details regarding the Brucella reference strains are provided in S1 Table.
Cinzia Marianelli (572423), Massimiliano Francia (340618), Paolo Pasquali (67847), Katiuscia Zilli (3714313), Manuela Tittarelli (4909870), Michela Tarantino (340619), Flavio De Maio (659073), Maurizio Sanguinetti (145176), Michela Sali (384739), Giuliano Garofolo (362476), Lorena Sacchini (3499175), Rosanna Adone (340615), Paola Petrucci (67850)   +12 more
core   +1 more source

A Molecular Engineering Strategy to Fine‐Tune Phototoxicity of AIE Probes for Super‐Resolution Imaging of Mitochondrial Cristae Dynamics

Advanced Science, EarlyView.
Regulation of molecular packing, phototoxicity, and ROS output of AIE photosensitizers is achieved through carboxylation and alkyl‐chain‐length tuning. The probe designed via this strategy enables super‐resolution visualization of inner‐mitochondrial‐membrane cristae dynamics under controlled oxidative stress, and fluorescence‐lifetime imaging of ...
Kongqi Chen, Mengjie Wang, Chuen Kam, Zhiming Wang, Qinrong Zhang, Sijie Chen   +5 more
wiley   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Comparison of Two Bacterial Characterization Techniques for the Genomic Analysis of River Microbiomes

Applied Microbiology, 2023
This study compares the feasibility of matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry with whole genome sequencing (WGS) for identifying bacteria in river surface water samples.
Roberto Bonnelly, Victor V. Calderon, Irene Ortiz, Argeny Ovando, Confesora Pinales, Willy Lara, Santo E. Mateo-Perez, Oscar Cardenas-Alegria, Rommel T. Ramos, Yaset Rodríguez-Rodríguez, Luis O. Maroto Martín, Edian F. Franco   +11 more
doaj   +1 more source

An Efficient Detection Platform Based on Mesoporous Au@Cr2O3 Particles with Schwarz P Surface for Precise Periodontitis Metabolite Profiling

Advanced Science, EarlyView.
A non‐invasive periodontitis diagnosis platform was developed using Au nanoparticles‐decorated mesoporous Cr2O3 (Au@mCr2O3) particles with Schwarz P surface as matrix for saliva metabolic fingerprinting (SMFs) analysis via MALDI‐MS. With the assistance of machine learning of SMFs, this platform enables efficient diagnosis and the screening of potential
Yue Sun, Yan Wang, Fangying Shi, Wenhe Xie, Yiding Zhang, Heyuhan Zhang, Chunhui Deng, Limin Wu, Meihua Chen, Yonghui Deng   +9 more
wiley   +1 more source

How To: Identify Non-Tuberculous Mycobacterium Species By Using Maldi-Tof Mass Spectrometry.

, 2017
<p><b>BACKGROUND: </b>The implementation of MALDI-TOF MS for microorganism identification has changed the routine of the microbiology laboratories as we knew it.
Ceyssens, P J, A. Ingebretsen, L. Quiroga, Corcoran, D, Palop, B, A. Van den Bossche, J. van Ingen, J. O\u27Mahony, R. Gorton, G. Hery-Arnaud, P.J. Ceyssens, European Study Group on Genomics and Molecular Diagnosis (ESGMD), Orth-Höller, D, O'Reilly, B, B. Rodriguez-Sanchez, Coll, P, Palacios, J J, Alcaide, F, J. Hrábak, I. González-Álvarez, Hrábak, J, G. Greub, van Ingen, J, Rodriguez-Sanchez, B, Oviaño, M, Amlerová, J, Ingebretsen, A, Opota, O, Marekoviċ, I, B. Palop, B. O\u27Reilly, Mediavilla-Gradolph, C, I. Marekoviċ, A. Pranada, Tudó, G, Lucey, B, O'Connor, J, F. Alcaide, J. O\u27Connor, Hery-Arnaud, G, M.S. Fangous, P. Coll, Bou, G, C. Mediavilla-Gradolph, Greub, G, O. Opota, Ruiz-Serrano, M J, Fangous, M-S, Rodríguez-Temporal, D, Monté, M R, D. Rodríguez-Temporal, Van den Bossche, A, M. Oviaño, G. Tudó, G. Bou, Gorton, R, D. Corcoran, González-Álvarez, I, J. Amlerová, B. Lucey, Pranada, A B, J.J. Palacios, O'Mahony, J, D. Orth-Höller, Quiroga, L, M.J. Ruiz-Serrano   +65 more
core   +1 more source

Matrix-assisted laser desorption/ionization time of flight mass spectrometry for comprehensive indexing of East African ixodid tick species [PDF]

, 2016
Background: The tick population of Africa includes several important genera belonging to the family Ixodidae. Many of these ticks are vectors of protozoan and rickettsial pathogens including Theileria parva that causes East Coast fever, a debilitating ...
Olds, C., Pflüger, V., Stephen Mwaura, Julian Rothen, Cassandra Olds, Bishop, Richard P., Daubenberger, C.A., Richard P. Bishop, Olds, Cassandra L., Pflueger, V., Esther G. Kanduma, Githaka, Naftaly W., Daubenberger, C., Rothen, J., Valentin Pflüger, Githaka, N., KAnduma, E. G., Mwaura, S., Bishop, R. P., Naftaly Githaka, Claudia Daubenberger, Kanduma, Esther G.   +21 more
core   +1 more source

Design and Engineering of an Artificial Bifunctional N‐Deacetylase/N‐Sulfotransferase for the Biosynthesis of N‐Sulfated Heparosan

Advanced Science, EarlyView.
An artificial bifunctional N‐deacetylase/N‐sulfotransferase was engineered in Escherichia coli by combining screened N‐deacetylases with an NST domain. The integrated engineering strategy improved enzyme performance. The optimized enzyme efficiently converted heparosan into N‐sulfated heparosan, addressing a key bottleneck in microbial heparin ...
Xintong Xi, Ruirui Xu, Daoan Wang, Guobin Yin, Xinjing Wang, Haiqin Chen, Guocheng Du, Jian Chen, Zhen Kang   +8 more
wiley   +1 more source

A MALDI-TOF Approach to Ubiquitin Ligase Activity [PDF]

Cell Chemical Biology, 2018
In this issue of Cell Chemical Biology,De Cesare et al. (2018) report the development of a high-throughput assay that measures E2/E3 enzyme activity by MALDI-TOF mass spectrometry and apply this to screen for small molecule E3 inhibitors. This assay potentially accelerates the drug discovery for the ubiquitin ligation pathway.
Tol, B.D.M. van, Geurink, P.P., Ovaa, H.
openaire   +3 more sources

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source