Results 91 to 100 of about 197,934 (334)

Mould routine identification in the clinical laboratory by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. [PDF]

open access: yesPLoS ONE, 2011
BACKGROUND: MALDI-TOF MS recently emerged as a valuable identification tool for bacteria and yeasts and revolutionized the daily clinical laboratory routine. But it has not been established for routine mould identification. This study aimed to validate a
Carole Cassagne   +7 more
doaj   +1 more source

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry [PDF]

open access: yes, 2014
Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets. We have developed a sensitive
A Iphofer   +62 more
core   +3 more sources

Rapid Discrimination of Methicillin-Resistant Staphylococcus aureus by MALDI-TOF MS

open access: yesPathogens, 2019
Methicillin-resistant Staphylococcus aureus (MRSA) is a serious pathogen in clinical settings and early detection is critical. Here, we investigated the MRSA discrimination potential of matrix-assisted laser desorption ionization time-of-flight mass ...
Jung-Min Kim   +5 more
semanticscholar   +1 more source

Construction of PANoptosis‐Inhibiting Carbonized Polymer Dots via Machine Learning Potential for Mitigating Chemodrug‐Induced Nephrotoxicity

open access: yesAdvanced Science, EarlyView.
An enhanced sampling method is developed for molecular dynamics based on trained machine learning force fields to guide the construction of PANoptosis‐inhibiting carbonized polymer dots (Lu‐CDs) derived from a flavonoid compound for treating chemodrug‐induced nephrotoxicity.
Xinchen Liu   +8 more
wiley   +1 more source

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

open access: yesAdvanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen   +8 more
wiley   +1 more source

Investigations of the lysophospholipid composition of human neutrophils under different stimulation conditions by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry [PDF]

open access: yesJournal of the Serbian Chemical Society, 2002
Matrix-assisted laser desorption / ionization time-of-flight mass spectrometry (MALDI-TOF MS) is usually used for the analyses of proteins carbohydrates and oligonucleotides.
Petković Marijana   +4 more
doaj   +1 more source

MALDI-TOF ICMS for bacterial classification and identification : how many cells are needed? [PDF]

open access: yes, 2012
The identification of species is fundamental to taxonomy. In microbiology, information about each microorganism (e.g., morphological and molecular descriptions, physiological and biochemical properties, ecological roles, and societal risks or benefits)
Cunha, J. T.   +4 more
core  

Use of matrix-assisted laser desorption ionization-time of flight mass spectrometry to identify vancomycin-resistant enterococci and investigate the epidemiology of an outbreak [PDF]

open access: yes, 2012
The control of vancomycin-resistant enterococci (VRE) has become an increasing burden on health care resources since their discovery over 20 years ago.
Griffin, Paul M.   +7 more
core   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

open access: yesAdvanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz   +10 more
wiley   +1 more source

New insights for identification of clinical isolates of Trichophyton rubrum using MALDI-TOF MS [PDF]

open access: yes, 2012
Dermatophytoses are the most common fungal infection worldwide with a nondespicable impact in health-care costs. Trichophyton rubrum is an antropophilic dermatophyte species very well adapted to human host causing chronic and slowly progressing ...
Dias, Nicolina Marques   +3 more
core  

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