Results 91 to 100 of about 316,007 (306)

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Redefining therapeutic landscapes: clinicopathological insights into low and ultra-low HER2 expression in male breast cancer

Diagnostic Pathology
Objective With the emergence of new antibody coupled drugs, the treatment decisions of patients with low and ultra-low HER2 expression have been reshaped.
Jiuyan Shang, Jiaxian Miao, Shuyao Niu, Xuemei Sun, Yueping Liu   +4 more
doaj   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Oral Bioinspired Peroxisome‐Engineered Probiotics for Modulating Gut Microbiota Homeostasis and Alleviating Cardiac Chemotherapy Toxicity

Advanced Science, EarlyView.
This study developed an oral bioinspired peroxisome‐engineered probiotic (BPEP) by anchoring lipid‐encapsulated ruthenium nanozymes onto Escherichia coli Nissle 1917, utilizing probiotics to deliver nanozymes to the intestinal barrier for reactive oxygen species/reactive nitrogen species elimination, tight junction restoration, and gut microbiota ...
Shuyu Wang, Xiaowan Fan, Chao Zhang, Shuai Han, Yike Guo, Yuchen Wang, Wei Wang, Junyue Xing, Ying Liu, Wei Jiang, Xiaoying Chen   +10 more
wiley   +1 more source

Premenopausal mammographic density in relation to cyclic variations in endogenous sex hormone levels, prolactin, and insulin-like growth factors.

, 2009
Mammographic density is strongly associated with breast cancer risk, and endogenous hormones, which are risk factors for breast cancer, may be involved in the mechanism.
Walker, Kate, Folkerd, Elizabeth, Fletcher, O, Hillier, Stephen G, dos Santos Silva, Isabel, Gibson, Lorna, McCormack, VA, Folkerd, E, Walker, K, Moss, S, Peto, Julian, Moss, Sue, Johnson, Nichola, Fletcher, Olivia, Coupland, Ben, Coupland, B, Holly, Jeff M, Dowsett, Mitchell, Gibson, L, Dowsett, M, Peto, J, Johnson, N, dos Santos Silva, I, Holly, JMP, Hillier, SG, McCormack, Valerie A   +25 more
core   +1 more source

Men's decision-making about predictive BRCA1/2 testing: the role of family [PDF]

, 2005
Men who have a family history of breast and/or ovarian cancer may be offered a predictive genetic test to determine whether or not they carry the family specific BRCA1/2 mutation.
Moynihan, C., R. Eeles, A. Lucassen, Eeles, R., Hallowell, N., A. Ardern‐Jones, C. Foster, Ardern-Jones, A., M. Watson, Lucassen, A., Foster, C., Watson, M., C. Moynihan, N. Hallowell   +13 more
core   +1 more source

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

Case report: Unraveling a unique case of male occult breast cancer with axillary intricacies and a comprehensive literature dive

Frontiers in Oncology
Male breast cancer is a rare neoplasm, accounting for approximately 1% of all breast cancer cases. It typically presents as a painless, retroareolar mass.
Xintong Xie, Xiangyi Kong, Xiangyi Kong, Hongnan Jiang, Jidong Gao, Jidong Gao   +5 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Quality of life in male breast cancer patients: psychosocial impacts and therapeutic strategies [PDF]

Journal of Men's Health
Male breast cancer (MBC) is a rare malignant tumor that is infrequently diagnosed in men. This leads to a lower quality of life (QOL) in men adversely affecting their overall well-being. Therefore, we aimed to summarize and disseminate the evidence on
Yeonsoo Pyo, Youn Sug Jeon
doaj   +1 more source