Results 71 to 80 of about 5,350,224 (255)
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer [PDF]
, 2013 IntroductionBreast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating ...Gee, Julia M. W., Hulbert-Williams, Nicholas J., Anderson, Annie, Martin, S.G., Stingl, J., Key, Timothy, Hunter, MS, Walker, Rosemary, Martin, SG, Stephen Hiscox, O’Connor, Rosemary, Smalley, Matthew J., Aboagye, Eric, Williams, K.J., Christine J Watson, Annie S Anderson, Robert B Clarke, Bundred, Nigel, Tutt, Andrew N J, Jo Armes, Evans, D, Brown, N.J., Smalley, Matthew J, Clarke, R.B., Charles H. Streuli (7669838), Eric O Aboagye, Bundred, Nigel J., Groves, Ashley, Aboagye, Eric O., John M. Saxton (7244180), Watson, Christine, Watson, C.J., Montserrat Garcia-Closas (89866), Palmieri, C., Anderson, Annie S.; id_orcid, Miller, WR, Moss, SM, Evans, D., Burchell, JM, Nicola J. Brown (7596590), John F. Marshall (7957925), John M Saxton, Amanda J Harvey, Eccles, Suzanne A., Flanagan, James, Bharat Jasani, Fedor Berditchevski, Pharoah, Paul D.P., Marshall, John F., Stingl, John, Peter Schmid, Macdougall, J.E., Cliona C. Kirwan (3934682), Duffy, Stephen W, Leach, M.O., Stein, R., Eccles, Suzanne A, Hunter, Myra, Miller, William R., Howell, Anthony, Stewart G Martin, Edwards, Dylan R., Kunkler, IH, Silva, IDOSS, Miles, D.W., Paul D P Pharoah, Ian H. Kunkler (7957919), Young, L.S., Evans, DG, Galina Velikova, Goh, V., Kong, A., Jasani, Bharat, Watson, CJ, Paul DP Pharoah (7957952), Gee, JM, Streuli, CH, Berditchevski, F., Walker, R.A., Nick Hulbert-Williams, Groves, Ashley M., Moss, Sue, Sahai, E, Jones, LJ, Goh, Vicky, Leach, Martin O., Charlotte E Coles, Gary JR Cook, Berditchevski, F, Hennessy, Bryan T., Carroll, J.S., Gee, Julia MW, Jennifer E Macdougall, Armes, Jo, Garcia-Closas, M., Aboagye, Eric O, Martin, L.A., O'Connor, J.P.B., Anthony Howell (23576), Key, Timothy J, Mullan, P, Kaye J Williams, Harvie, Michelle N., Brown, NJ, Miles, David, Harvey, AJ, Rakha, Emad A, Isabel dos Santos Silva, Thompson, Alastair M., Palmieri, C, Miller, W.R., David W Miles, Velikova, Galina, Moss, S.M., Bryant, Helen E, Cox, A, Jo Armes (3480905), Reed, E., Eccles, Diana M., Marshall, JF, Cook, Gary J. R., William R Miller, Pharoah, P.D.P., Anderson, Annie S, Fedor Berditchevski (3827920), Duffy, SW, Young, Leonie, Nicola J Brown, Martin, Stewart, Hubbard, G., Saxton, John M., Dekker, Lodewijk, Brown, Nicola, Bundred, N.J., Martin, LA, Cox, Angela, Armes, J., William M. Gallagher (265756), Charlotte E. Coles (7688222), Andrew N J Tutt, Alastair M Thompson, Aboagye, EO, Simak Ali, Paul Mullan (6534653), Jones, Louise, Rosemary O'Connor (94873), Coles, Charlotte E, Evans, D. Gareth, Burchell, Joy, Jeremy P. Blaydes (7957853), Hiscox, Stephen, Deborah F. Fenlon (7957892), Robert Stein, Speirs, Valerie, Simon P. Robinson (7957958), Hulbert-Williams, N., Joy M Burchell, Claire Foster (768031), Julia MW Gee (7957898), Julia M W Gee, D Gareth Evans (7957889), Michelle Harvie (3455429), Gee, Julia M.W., Easton, Douglas F, Gescher, A.J., Jasani, B., Key, Timothy J., Bryan T Hennessy, Smalley, Matthew John, O'Connor, JP, Williams, Kaye J, Cook, Gary, Bryant, Helen E., Eccles, DM, O’Connor, JPB, Schmid, P., David W. Miles (7957937), Rakha, Emad A., Robinson, Simon P., Sue M Moss, Blaydes, J.P., John F Marshall, Jason S Carroll, Langdon, Simon P, Cook, Gary Jr, Fenlon, D.F., Macdougall, Jennifer E., Sue M. Moss (7957943), Douglas F. Easton (7957880), Suzanne A Eccles, Evans, D.G., Angela Cox (76913), Harvey, A.J., Rosemary A Walker, Howell, A., Stein, Robert, Evans, D.Gareth, Martin, Stewart G., Edwards, Dylan, David J. Mann (2820133), O'Connor, R, Jennifer E. Macdougall (7957934), Hennessy, Bryan T, Edwards, Joanne, O'Connor, James P. B., Carroll, Jason, Anderson, A.S., Gill Hubbard (3403994), Robinson, SP, Groves, Ashley M, Hulbert-Williams, N, Watson, Christine J, Amanda J. Harvey (7957904), Kirwan, Cliona C.; id_orcid, Speirs, V, Campbell, AM, Cook, Gary J., Bryant, Helen, Coles, Charlotte E., Fenlon, Deborah F., Martin, Lesley, Blaydes, Jeremy P, Martin O Leach, Erik Sahai, Ashley M. Groves (7957901), Williams, Kaye J., Langdon, Simon P., O’Connor, James P., Bryant, HE, Edwards, J, Blaydes, JP, Emad A Rakha, Morris, Joanna R., Groves, A.M., Louise J Jones, Thompson, AM, Easton, Douglas F., Dekker, LV, Jasani, B, Harvey, Amanda J., Howell, S.J., Anna M Campbell, Saxton, JM, Vicky Goh (577982), Leach, Martin O, Stephen W Duffy, Tutt, Andrew NJ, Ali, S., Blaydes, Jeremy P., Howell, Sacha J.; id_orcid, Louise J. Jones (7957916), Harvie, Michelle, Clarke, Robert B, Lesley Ann Martin, Garcia-Closas, Montserrat, Kunkler, Ian H., Angela Cox, Leach, MO, Fenlon, Deborah, dos Santos Silva, Isabel, Leonie Young (7895759), Pharoah, Paul D. P., Harvey, Amanda, Rakha, Emad, Jones, L.J., Morris, JR, Campbell, Anna, Kunkler, Ian H, Reed, Elizabeth, Douglas F Easton, Deborah F Fenlon, Berditchevski, Fedor, Coles, C.E., Gallagher, W.M., Carlo Palmieri (681317), Howell, A, Brennan, K, Rakha, EA, Rosemary A. Walker (7580297), Jeremy P Blaydes, Duffy, Stephen, Matthew J. Smalley (7957961), Sacha J Howell, Gescher, Andy, Macdougall, JE, Elizabeth Reed (3138513), Natrajan, R., O'Connor, R., Montserrat Garcia-Closas, Bundred, Nigel J, Nicola J. Curtin (351064), Holen, Ingunn, Carroll, JS, Goh, Vicky; id_orcid, Alastair M. Thompson (7957970), Bryan Hennessy (7898999), Cook, GJR, Brown, Nicola J, Reed, E, Kirwan, CC, Hunter, Myra S., Walker, Rosemary A., Robinson, S.P., Michelle Harvie, Duffy, S.W., Saxton, John, Ingunn Holen, Suzanne A Eccles (7957850), Brennan, K., Gallagher, William, Rosemary O’Connor, Isabel Dos Santos Silva (7957874), John Stingl, Andy J. Gescher (7671179), Joanna R Morris, Annie S. Anderson (6298127), Morris, Jo; id_orcid, Langdon, Simon, Rachel Natrajan (7957946), Ali, S, Hubbard, Gill, Vicky Goh, Sacha J. Howell (7957907), Smalley, M.J., Holen, I, Sahai, E., Helen E Bryant, Edwards, Dylan R, Edwards, D.R., Cliona C Kirwan, Stein, R, Simon P Robinson, Timothy J. Key (7755380), James M Flanagan, Martin, Lesley Ann, Nick Hulbert-Williams (7957910), Morris, Joanna, Brown, Nicola J., Silva, Isabel dos Santos, Nicola J Curtin, Foster, Claire, Kaye J. Williams (7957967), Paul Mullan, Nigel J. Bundred (7957859), Curtin, NJ, Gee, Julia M W, Eccles, Diana, Campbell, Anna M, Streuli, C.H., Tutt, Andrew, Fenlon, Deborah F, Clarke, Robert B., Mullan, P., Silva, IDS, Gee, J.M.W., Morris, J.R., Valerie Speirs (1679), O'Connor, James, Cook, Gary J R, O’Connor, James P.B., Campbell, A.M., Easton, DF, Watson, Christine J., Goh, V, Bryant, H.E., Eric O. Aboagye (309960), Marshall, J.F., Howell, Anthony; id_orcid, Burchell, Joy M, Tutt, AN, Easton, Douglas, Tutt, A.N.J., Jones, Louise J, Streuli, Charles H, Hiscox, S., Schmid, Peter, Joanne Edwards (589089), Gallagher, William M, Stingl, J, Dekker, L.V., Claire Foster, Robinson, Simon P, Curtin, Nicola, Gee, Julia, Tutt, ANJ, Howell, Sacha, Saxton, J.M., Foster, C., Miles, David W, Erik Sahai (829065), Thompson, A.M., Mullan, Paul, Kirwan, Cliona C, James PB O’Connor, Mann, DJ, Rakha, E.A., Pharoah, Paul DP, Helen E. Bryant (7957856), Burchell, Joy M., Natrajan, R, Harvie, M, Carlo Palmieri, Gescher, Andy J, Macdougall, Jennifer E, Hubbard, G, Hulbert-Williams, Nick, Mann, David, Clarke, Robert, Cook, Gary J.R., Anthony Howell, Dekker, Lodewijk V, Hennessy, B.T., Young, Leonie S., Joy M. Burchell (7957862), Foster, C, Key, T.J., Moss, Sue M, Williams, Kaye, Peter Schmid (81036), D Gareth Evans, Hubbard, Gill; id_orcid, Ashley M Groves, Curtin, Nicola J., Gescher, AJ, Joanna R. Morris (7957940), Clarke, RB, Streuli, Charles, Palmieri, Carlo, Martin O. Leach (454145), Mann, David J., Ingunn Holen (3637012), Marshall, John, Simon P Langdon, Bundred, NJ, Gill Hubbard, Keith Brennan (1659), Young, LS, Timothy J Key, Kong, A, dos Santos Silva, I, Eccles, SA, Marshall, John F, Miller, William, Fenlon, DF, Charles H Streuli, Langdon, SP, Pharoah, Paul, Hunter, M.S., Streuli, Charles H., Matthew J Smalley, Smalley, MJ, Kirwan, Cliona C., Christine J. Watson (7585901), Gescher, Andy J., Tutt, Andrew N. J., Kunkler, Ian, Robinson, Simon, Keith Brennan, O’Connor, R, Eccles, S.A., Cook, G.J.R., Valerie Speirs, Kong, Hee, Curtin, N.J., Dylan R. Edwards (7957886), Hiscox, S, Edwards, DR, Gary Jr Cook (7957868), Nigel J Bundred, Eccles, Diana M, James M. Flanagan (7957895), Leach, Martin, Speirs, V., James PB O'Connor (7957949), Howell, Sacha J., Joanne Edwards, Coles, Charlotte, Emad A. Rakha (7957955), Key, TJ, Carroll, Jason S, Rachel Natrajan, Stephen W. Duffy (7957877), Walker, RA, Kong, Anthony, Eccles, Suzanne, Miles, DW, Gallagher, William M., Curtin, Nicola J, Stewart G. Martin (7957931), Ali, Simak, Jones, Louise J., Bharat Jasani (4954081), Howell, Sacha J, Mann, David J, Valikova, G., Dylan R Edwards, Macdougall, Jennifer, Blaydes, Jeremy, Miles, David W., Miller, William R, Burchell, Joy M; id_orcid, Kunkler, I.H., Anderson, AS, Armes, J, Groves, AM, Diana M. Eccles (7957883), Mann, D.J., Andy J Gescher, Flanagan, James M., O'Connor, James P B, Eccles, D.M., Garcia-Closas, M, Flanagan, J.M., Kirwan, C.C., Pharoah, Paul D P, Leonie S Young, Ian H Kunkler, Anderson, Annie S., Hennessy, Bryan, dos Santos Silva, I., Deborah Fenlon, Myra S Hunter, O'Connor, JPB, Galina Velikova (3069645), Hiscox, Stephen Edward, Carroll, Jason S., David J Mann, Holen, I., Campbell, Anna M., Flanagan, JM, Aboagye, E.O., Pharoah, PD, Velikova, G, Harvey, Amanda J, Martin, Stewart G, Sahai, Erik, Martin, L, Stephen Hiscox (361114), Cook, Gary JR; id_orcid, Coles, CE, Williams, KJ, Silva, IS, Morris, Joanna R, Lodewijk V Dekker, Hennessy, BT, Thompson, Alastair M, Simak Ali (12335), Pharoah, PDP, Saxton, John M, Cook, GJ, Evans, D. G., Andrew NJ Tutt (7957964), Simon P. Langdon (7957922), Dekker, Lodewijk V., Anna M. Campbell (7957865), Moss, Sue M., Gee, JMW, Lesley A. Martin (7957928), Harvie, M., Clarke, Robert; id_orcid, O'Connor, Rosemary, Natrajan, Rachel, Cox, A., Edwards, J., Young, Leonie S, Anthony Kong, Smalley, Matthew, Diana M Eccles, William M Gallagher, Elizabeth Reed, Schmid, P, Brennan, Keith, Langdon, S.P., Duffy, Stephen W., Easton, D.F., Walker, Rosemary A, Kirwan, Cliona, Flanagan, James M, O'Connor, James Pb, Gallagher, WM, Martin, Lesley A., Anthony Kong (94738), Gee, Julia Margaret Wendy, Howell, SJ, Hunter, Myra S, Myra S. Hunter (7957913), Lodewijk V V. Dekker (7957871), William R. Miller (1372755), Robert Stein (1704328), John Stingl (444979), Jason S. Carroll (7901276), Burchell, J.M., Robert B. Clarke (7948805), Robinson, S P, Bryant, H E, Key, T J, Easton, D F, Watson, C J, Fenlon, D F, Pharoah, P D P, Tutt, A N J, Groves, A M, Jones, L J, Leach, M O, Coles, C E, Flanagan, J M, Gescher, A J, Mann, D J, Martin, S G, Morris, J R, Silva, I S, Walker, R A, Langdon, S P, Anderson, A S, Miller, W R, Moss, S M, Gallagher, W M, Burchell, J M, Saxton, J M, Rakha, E A, Harvie, Michelle N, Duffy, S W, Harvey, A J, Hunter, M S, Thompson, A M, Marshall, J F, Curtin, N J, Blaydes, J P, Hennessy, B T, Young, L S, Hulbert-Williams, Nick; id_orcid, Aboagye, E O, Brown, N J, Eccles, D M, Kunkler, I H, Smalley, M J, Eccles, S A, Edwards, D R, Dekker, L V, Macdougall, J E, Campbell, A M, Carroll, J S, Miles, D W, Cook, G J R, Evans, D Gareth R, Gee, J M W +645 morecore +3 more sourcesCoixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma
Advanced Science, EarlyView.Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu +20 morewiley +1 more sourceModulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties
Advanced Science, EarlyView.Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen +16 morewiley +1 more sourceInfluence of stromal–epithelial interactions on breast cancer in vitro and in vivo
, 2019 Stromal cell-secreted chemokines including CCL2 have been implicated in the primary tumor microenvironment, as mediators of tumor cell migration, proliferation, and angiogenesis.Dwyer, Róisín M., Hartmann, Marion C., Khan, Sonja, Potter, Shirley M., Boyle, Marie P., Curran, Catherine E., Kerin, Michael J. +6 morecore +1 more sourceHistone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop
Advanced Science, EarlyView.In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun +6 morewiley +1 more sourceAusencia de la mutación BRCA1 del (exones 9-12) en familias con cáncer de seno / ovario fuera de hispanos mexicanos [PDF]
, 2009 3 páginasThe frequency and spectrum of germ line mutations in the
high-penetrance breast cancer susceptibility genes BRCA1
and BRCA2 shows considerable variation by ethnic group.Seidel Renkert, Antje, Colombian Breast Cancer Study Group (COLBCS), Torres, Diana, Seidel-Renkert, Antje, Rashid, Muhammad U., Briceño Balcázar, Ignacio, Weitzel, Jeffrey N., Hamann, Ute, Briceno, Ignacio +8 morecore +1 more source
