Results 61 to 70 of about 5,350,224 (255)

GGNBP2 suppresses triple-negative breast cancer aggressiveness through inhibition of IL-6/STAT3 signaling activation

, 2018
Background Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, lacking effective targeted therapies, and whose underlying mechanisms are still unclear.
Liu, Jingjing, Yang, Qianxi, Zhang, Jin, Hu, Yunhui, Zhao, Hui, Pan, Teng, Liu, Lei, Yagüe, Ernesto   +7 more
core   +1 more source

Mammographic breast density refines Tyrer-Cuzick estimates of breast cancer risk in high-risk women: findings from the placebo arm of the International Breast Cancer Intervention Study I [PDF]

, 2014
Introduction: Mammographic density is well-established as a risk factor for breast cancer, however, adjustment for age and body mass index (BMI) is vital to its clinical interpretation when assessing individual risk.
Howell, Anthony; id_orcid, Jennifer Stone, Cuzick, Jack, Pinney, E, Jane Warwick, Pinney, Elizabeth, Stone, J, Stone, Jennifer, Cuzick, J, Ruth ML Warren, Duffy, Stephen W., Warwick, J, Warren, Ruth ML, Warren, RML, Howell, A, Birke, Hanna, Duffy, SW, Jack Cuzick, Duffy, Stephen W, Bretnall, Adam, Warren, Ruth, Birke, [Unknown], Warwick, Jane, Howell, Anthony, Brentnall, AR, Elizabeth Pinney, Adam R Brentnall, Stephen W Duffy, Anthony Howell, Hanna Birke, Brentnall, Adam R., Birke, H   +31 more
core   +2 more sources

Survival Outcomes in Older Adults with Axial Spondyloarthritis and Concomitant Cancer

Arthritis Care &Research, Accepted Article.
Objective The objective of this study was to determine survival outcomes in older adults with axial spondyloarthritis (axSpA) and concomitant cancer. Methods We conducted a population‐based study using Medicare claims data linked to Surveillance, Epidemiology, and End Results data to determine overall survival (OS) and cancer‐specific survival (CSS) in
Savannah Bowman, Mei Li, Xiudong Lei, Hui Zhao, Juan I. Ruiz, Sharon H. Giordano, Alexis R. Ogdie, Maria E. Suarez‐Almazor   +7 more
wiley   +1 more source

A Synchronous Diagnosis of Metastatic Male Breast Cancer and Prostate Cancer

Journal of Investigative Medicine High Impact Case Reports, 2019
In this article, we present a patient diagnosed synchronously with metastatic male breast cancer and prostate cancer. This is a 63-year-old male and recent immigrant from Nigeria, who sought medical attention for progressively worsening of shortness of ...
Leila Moosavi MD, Phyllis Kim MD, An Uche MD, Everardo Cobos MD, FACP   +3 more
doaj   +1 more source

Mammographic density and molecular subtypes of breast cancer. [PDF]

, 2012
BACKGROUND: Gene expression profiling has led to a subclassification of breast cancers independent of established clinical parameters, such as the Sorlie-Perou subtypes.
Bergh, J, P Hall, J Bergh, Dos Santos Silva, I, K Czene, Hall, P, Eriksson, L, McCormack, V, Ploner, A, Czene, K, Bjohle, J, V McCormack, J Bjohle, A Ploner, L Eriksson, I dos Santos Silva, Silva, IDS, Hall, P,, Eriksson, L,, Ploner, A,, Bergh, J,, Czene, K,   +21 more
core   +1 more source

Myogenic Fusogen‐Engineered Lipid Nanoparticles Enhance mRNA Delivery in Skeletal Muscle

Advanced Functional Materials, EarlyView.
This study reports a biomimetic strategy of engineering full‐length Myomaker, a muscle‐specific fusogen, into lipid nanoparticles (LNPs) to harness the native myoblast fusion capability for skeletal muscle mRNA delivery. The resulting Mymk‐LNPs enhance transfection in differentiating myocytes and enable Cre‐mediated reporter activation in injured ...
Fangyu Zhang, Zhisheng Xu, Yaou Duan, Yehui Sun, Shiying Wu, Tao Long, Mateusz Durbacz, Li Zhang, Yufen Xiao, Yu‐Chung Pien, Erick D. Guerrero, Zeru Tian, Xu Wang, Pratima Basak, Sumanta Chatterjee, Ning Liu, Xiaochun Li, Eric N. Olson, Daniel J. Siegwart   +18 more
wiley   +1 more source

Intelligent Orthopedics: Machine Learning in Diagnosis of Bone Disease, Implants, and Bone Health Monitoring

Advanced Healthcare Materials, EarlyView.
Efficient recovery from traumatic or degenerative diseases is a great challenge, even after all the advancements in bone and cartilage regeneration. Machine learning (ML) algorithms have presented opportunities to enhance these aspects by accurately analyzing imaging data.
Maryam Kamaei, Hesam Mohammadi, Shamim Golafshan, Mojtaba Alehosseini, Mahsa Mohammadzadeh, Atefeh Golshirazi, Nasim Golafshan, Tatiane Eufrásio‐da‐Silva, Alireza Dolatshahi‐Pirouz, Gorka Orive   +9 more
wiley   +1 more source

Redefining therapeutic landscapes: clinicopathological insights into low and ultra-low HER2 expression in male breast cancer

Diagnostic Pathology
Objective With the emergence of new antibody coupled drugs, the treatment decisions of patients with low and ultra-low HER2 expression have been reshaped.
Jiuyan Shang, Jiaxian Miao, Shuyao Niu, Xuemei Sun, Yueping Liu   +4 more
doaj   +1 more source

Bilateral male breast cancer with male potential hypogonadism

World Journal of Surgical Oncology, 2007
Background Male breast cancer is a comparatively rare disease, and simultaneous bilateral male breast cancer is considered to be an extremely rare event.
Kurokawa Yasushi, Morimoto Tadaoki, Hirose Toshiyuki, Bando Yoshimi, Sasa Mitsunori, Hirose Yukiko, Nagao Taeko, Tangoku Akira   +7 more
doaj   +1 more source

Tumbling Magnetic Microrobots for Targeted In Vivo Drug Delivery in the GI Tract

Advanced Robotics Research, EarlyView.
We introduce a microrobot design and integrated system for on‐demand targeted drug release in the gastrointestinal tract. The microrobot has an embedded magnet for actuation with external magnetic fields and is visualized in real time using ultrasound. It has two drug release ports sealed with a thermally sensitive wax. Local heating of the wax using a
Aaron C. Davis, Luis Carlos Sanjuan Acosta, Shubh P. Mehta, Baiyan Qi, Yang Yang, Luis Solorio, Craig J. Goergen, David J. Cappelleri   +7 more
wiley   +1 more source