Results 81 to 90 of about 5,350,224 (255)

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Pattern of Breast Cancer in a Tertiary Care Center

Journal of Nepal Medical Association, 2010
INTRODUCTION: Breast Cancer is the second commonest cause of cancer death in women. Almost all women survive breast cancer if it is detected before it starts to spread.
A K Jha, P K H, J Jha, P Banthia, K Thakali, B K Basnet   +5 more
doaj   +1 more source

A descriptive study of the genetic counseling environment of men with breast cancer in the United States [PDF]

, 2013
In society, breast cancer is erroneously considered to be a female disease. Information regarding the psychosocial, sociocultural, and familial experiences of men diagnosed with breast cancer remains scant.
Hight, Elizabeth
core  

Inconsistent association between the STK15 F31I genetic polymorphism and breast cancer risk.

, 2006
STK15 may be a low-penetrance breast cancer susceptibility gene, and several reports suggest that women who are homozygous for the polymorphic variant F31I have an increased risk of breast cancer.
McCormack, Valerie, Whittaker, John, Isabel dos Santos Silva, dos Santos Silva, Isabel, Alan Ashworth, Nichola Johnson, Valerie Mccormack, John Whittaker, Peto, Julian, Johnson, Nichola, Fletcher, Olivia, Claire Palles, Olivia Fletcher, Isabel Dos Santos, Ashworth, Alan, Julian Peto, Palles, Claire   +16 more
core   +1 more source

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

Advanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger, Matthew R. DeWitt, Carly M. Van Wagoner, Claire A. Conarroe, Charles C. Funk, Aaron B. Streit, AeRyon Kim, Richard J. Price, Timothy N. J. Bullock   +8 more
wiley   +1 more source

Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.

, 2011
BACKGROUND: Genome-wide association studies have identified several common genetic variants associated with breast cancer risk. It is likely, however, that a substantial proportion of such loci have not yet been discovered.
Gibson, Lorna J, Jones, M, Tomlinson, IP, Ross, G, Lorna J. Gibson, Schoemaker, M, Lathrop, M, Ross, Gillian, Peto, Julian, Swerdlow, A, Gemma Simpson, Johnson, Nichola, Fletcher, Olivia, Coupland, Ben, Hosking, FJ, Minouk Schoemaker, Chanock, Stephen J., Williamson, Jill, Zelenika, D, Schoemaker, Minouk, Coupland, B, Fay J. Hosking, Simpson, Gemma, Palles, Claire, Gut, I, Jill Williamson, Kevin B. Jacobs, Jacobs, Kevin B, Ashworth, A, Katarzyna Tomczyk, Houlston, RS, Johnson, N, Gillian Ross, Chanock, SJ, Alan Ashworth, Swerdlow, Anthony, Hunter, DJ, Jones, Michael, Chilcott-Burns, S, Dos-Santos-Silva, Isabel, Stephen J. Chanock, Lathrop, Mark, Williamson, J, Simon Heath, Broderick, P, Sarah Chilcott-Burns, Isabel dos Santos Silva, Walker, Kate, Fletcher, O, Heath, S, dos Santos Silva, Isabel, Houlston, Richard S, Zelenika, Diana, Mark Lathrop, Tomczyk, K, Nichola Johnson, Walker, K, Ben Coupland, David J. Hunter, Claire Palles, Palles, C, Ashworth, Alan, Kate Walker, Tomczyk, Katarzyna, Tomlinson, Ian P, Simpson, G, Orr, Nick; id_orcid, Nick Orr, Peter Broderick, Orr, Nick, Orr, N, Swerdlow, Anthony J, Ivo Gut, Peto, J, Tomlinson, Ian, Michael Jones, dos Santos Silva, I, Jacobs, KB, Diana Zelenika, Ian P. Tomlinson, Gut, Ivo, Chanock, Stephen J, Broderick, Peter, Chilcott-Burns, Sarah, Olivia Fletcher, Gibson, LJ, Anthony Swerdlow, Walker-Springett, Kate, Richard S. Houlston, Hosking, Fay J, Heath, Simon, Julian Peto, Hunter, David J   +92 more
core   +1 more source

The feasibility of endoscopy-assisted breast conservation surgery for patients with early breast cancer [PDF]

, 2011
PURPOSE: Breast conservation surgery (BCS) has become a standard treatment method for patients with early breast cancer. Endoscopy-assisted BCS (EABCS) can be performed through an inconspicuous periareolar and a small axillary incision for sentinel node ...
이준상, Seho Park, 박형석, Seung-Il Kim, 김승일, Hyung Seok Park, Byeong-Woo Park, Jong Seok Lee, 이종석, Jun Sang Lee, 박병우, 박세호   +11 more
core   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source