Results 1 to 10 of about 413,452 (145)

Identification of immune cell infiltration and effective biomarkers of polycystic ovary syndrome by bioinformatics analysis

BMC Pregnancy and Childbirth, 2023
Background Patients with polycystic ovary syndrome (PCOS) exhibit a chronic inflammatory state, which is often accompanied by immune, endocrine, and metabolic disorders.
Mengge Gao, Xiaohua Liu, Mengxuan Du, Heng Gu, Hang Xu, Xingming Zhong   +5 more
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Comprehensive Analysis of circRNAs, miRNAs, and mRNAs Expression Profiles and ceRNA Networks in Decidua of Unexplained Recurrent Spontaneous Abortion

Frontiers in Genetics, 2022
The diagnosis and treatment of unexplained recurrent spontaneous abortion (URSA) are subject to debate, because the exact underlying mechanisms remain unclear. To address this issue, we elucidated the expression profiles of dysregulated circRNAs, miRNAs,
Xiaohua Liu, Xiaohua Liu, Jiabao Wu, Jiabao Wu, Hua Nie, Hua Nie, Xiaoli Zhu, Xiaoli Zhu, Ge Song, Ge Song, Lu Han, Lu Han, Weibing Qin, Weibing Qin   +13 more
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Prevalence of preconception TORCH infections and its influential factors: evidence from over 2 million women with fertility desire in southern China

BMC Women's Health, 2023
Background TORCH (Toxoplasma gondii [TOX], Cytomegalovirus [CMV], Rubella virus [RV], and Herpes simplex virus [HSV]) represents pathogens known to traverse the maternal-fetal barrier and cause severe neonatal anomalies. We aimed to assess the prevalence
Lu Han, Rui Li, Wenxue Xiong, Yang Hu, Jiabao Wu, Xiaohua Liu, Hua Nie, Weibing Qin, Li Ling, Mingzhen Li   +9 more
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A missense variant in NCF1 is associated with susceptibility to unexplained recurrent spontaneous abortion

Open Life Sciences, 2022
Unexplained recurrent spontaneous abortion (URSA) is a major concern in reproductive medicine. Neutrophil cytosolic factor 1 (NCF1) polymorphisms leading to low production of reactive oxygen species (ROS) are strongly associated with autoimmune diseases.
Du Mengxuan, Gu Heng, Li Yanqiu, Huang Liyan, Gao Mengge, Xu Hang, Deng Huaqian, Zhong Wenyao, Liu Xiaohua, Zhong Xingming   +9 more
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Immune micro-environment and drug analysis of peritoneal endometriosis based on epithelial-mesenchymal transition classification

Frontiers in Endocrinology, 2022
BackgroundEpithelial-mesenchymal transition (EMT) is a complex event that drives polar epithelial cells transform from adherent cells to motile mesenchymal cells, in which are involved immune cells and stroma cells.
Qingli Quan, Jiabao Wu, Meixing Yu, Jia Tang   +3 more
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Effects of varicocele and microsurgical varicocelectomy on the metabolites in semen

Scientific Reports, 2022
The influence of varicocele and microsurgical varicocelectomy on semen quality remains unclear. Few studies have investigated the relationship between semen metabolism and the abnormalities in reproductive function caused by varicocele, however, there is
Xinzong Zhang, Cuncan Deng, Wujiang Liu, Huang Liu, Yu Zhou, Qianyi Li, Houbin Zheng, Qiling Wang, Min Jiang, Tao Pang, Chunjie Ma, Cheng Huang, Qingguo Zhao, Yunge Tang   +13 more
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“Seminal testosterone”, rising viewpoint of local spermatogenesis in nonobstructive azoospermia: One center long-term bidirectional cohort study

Frontiers in Endocrinology, 2022
ObjectiveReproductive hormones are a traditional good method to evaluate spermatogenesis but might not accurately represent local spermatogenesis. To find a more accurate method, seminal reproductive hormones were studied.MethodsA bidirectional cohort ...
Huang Liu, Houbin Zheng, Yuehua Li, Yuqian Tang, Hongbo Peng, Qianyi Li, Jiaming Zhuang, Yingyi Zhou, Yu Zhou, Xiang’an Tu, Xinzong Zhang   +10 more
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Jiawei Runjing Decoction Improves Spermatogenesis of Cryptozoospermia With Varicocele by Regulating the Testicular Microenvironment: Two-Center Prospective Cohort Study

Frontiers in Pharmacology, 2022
Objective: The aim of the study was to explore the evidence of JWRJD in the treatment of cryptozoospermia.Methods: A total of 162 cryptozoospermia patients with varicocele who refused to undergo surgery were included from January 2021 to December 2021 ...
Huang Liu, Huang Liu, Zhongwang Huang, Houbin Zheng, Zhiyong Zhu, Hui Yang, Xingzhang Liu, Tao Pang, Liping He, Hai Lin, Lei Hu, Qingqi Zeng, Qingqi Zeng, Lanying Han   +13 more
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High Throughput scRNA-Seq Provides Insights Into Leydig Cell Senescence Induced by Experimental Autoimmune Orchitis: A Prominent Role of Interstitial Fibrosis and Complement Activation

Frontiers in Immunology, 2022
Leydig cells (Lc), located in the interstitial space of the testis between seminiferous tubules, produce 95% of testosterone in male individuals, which is pivotal for male sexual differentiation, spermatogenesis, and maintenance of the male secondary sex
Yinchuan Li, Yinchuan Li, Panpan Mi, Jiabao Wu, Yunge Tang, Xiaohua Liu, Jinmei Cheng, Yingying Huang, Weibing Qin, C. Yan Cheng, Fei Sun   +10 more
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Leydig cell metabolic disorder act as a new mechanism affecting for focal spermatogenesis in Klinefelter syndrome patients: a real world cross-sectional study base on the age

Frontiers in Endocrinology, 2023
BackgroundKlinefelter’s syndrome (KS) was once considered infertile due to congenital chromosomal abnormalities, but the presence of focal spermatozoa changed this.
Huang Liu, Zhenhui Zhang, Yong Gao, Hai Lin, Zhiyong Zhu, Houbin Zheng, Wenjing Ye, Zefang Luo, Zhaohui Qing, Xiaolan Xiao, Lei Hu, Yu Zhou, Xinzong Zhang   +12 more
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