Results 141 to 150 of about 177,590 (291)

Glycolytic Enzyme HK2 Phosphorylates nSMase1 to Promote Astrocytic Exosomes Biogenesis Contributing to Acute Ischemic Stroke Injury

open access: yesAdvanced Science, EarlyView.
This study reveals that the glycolytic enzyme HK2 mediates hypoxia‐induced astrocytic exosome biogenesis by directly phosphorylating nSMase1. These astrocytic exosomes impair brain endothelial tight junctions. Astrocyte‐specific knockdown of HK2 reduces exosome release and alleviates brain injury after MCAO.
Chen Chen   +12 more
wiley   +1 more source

Basic and clinical genetic studies on male infertility in Iran during 2000-2016: A review

open access: yesInternational Journal of Reproductive BioMedicine, 2018
The male factor contributes to 50% of infertility. The cause of male infertility is idiopathic and could be congenital or acquired. Among different factors which are involved in idiopathic male infertility, genetic factors are the most prevalent causes ...
Sahar Moghbelinejad   +3 more
doaj  

A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing

open access: yesAdvanced Science, EarlyView.
This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang   +17 more
wiley   +1 more source

Weak and Tunable Adhesion–Clutch Drives Rapid Cell Migration and Glioblastoma Invasion

open access: yesAdvanced Science, EarlyView.
This study proposes that adhesion–clutch can mediate both cell motility and immobilization depending on the force amplitude. Weak adhesion–clutch is well‐suited for cell migration, without forming strong adhesions that impede cell motility. It propels rapid dendritic cell migration controlled by extracellular chemicals, as well as pathologically ...
Kentarou Baba   +15 more
wiley   +1 more source

Lithium Exposure Causes Trophoblast Cuproptosis by Upregulating FOXO1/STEAP4 Axis in Unexplained Miscarriage

open access: yesAdvanced Science, EarlyView.
Li exposure up‐regulates FOXO1 expression levels and thus promotes FOXO1‐mediated STEAP4 transcription, up‐regulating STEAP4 levels. Subsequently, STEAP4 up‐regulates intracellular Cu+ ion levels and causes cuproptosis, which further induces miscarriage.
Shuaishuai Xing   +14 more
wiley   +1 more source

Male infertility - Current concepts

open access: yesIndian Journal of Urology, 2011
Rajeev Kumar
doaj   +1 more source

Critical Role of IL1R2‐ENO1 Interaction in Inhibiting Glycolysis‐Mediated Pyroptosis for Protection Against Lethal Sepsis

open access: yesAdvanced Science, EarlyView.
The authors have discovered that intracellular interleukin 1 receptor 2 (IL1R2) negatively regulates pyroptosis and inflammation by inhibiting glycolysis in sepsis. Soluble IL1R2 is released from macrophages undergoing pyroptosis. IL1R2 acts as a novel negative regulator of glycolysis by interacting with enolase 1 (ENO1), thereby inhibiting gasdermin D
Chuyi Tan   +13 more
wiley   +1 more source

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