Results 161 to 170 of about 2,744,238 (299)

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

Vitamin D in male reproduction: molecular mechanisms and pharmacological perspectives. [PDF]

Front Pharmacol
Liu J, Liu B, Qiu X, Lv M, Liu S, Zhou D.   +5 more
europepmc   +1 more source

The role of taurine in male reproduction: Physiology, pathology and toxicology. [PDF]

Front Endocrinol (Lausanne), 2023
Li Y, Peng Q, Shang J, Dong W, Wu S, Guo X, Xie Z, Chen C.   +7 more
europepmc   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Return of the forgotten hero: the role of Y chromosome-encoded Zfy in male reproduction. [PDF]

Mol Hum Reprod, 2023
Holmlund H, Yamauchi Y, Yamauchi Y, Ruthig VA, Cocquet J, Ward MA.   +5 more
europepmc   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Functional characterization of porcine septin12 and its role in male reproduction. [PDF]

Anim Biosci
Wang P, Zhang X, Huo H, Li L, Wen F, Wang S, Zhang Y, Turgong R, Huo J.   +8 more
europepmc   +1 more source

SIRT1: A Key Player in Male Reproduction. [PDF]

Life (Basel), 2022
Khawar MB, Sohail AM, Li W.
europepmc   +1 more source

The Rabbit Male Reproduction

This chapter aims to furnish the state of the art on rabbit male reproduction focusing on factors affecting semen quality (all fractions: spermatozoa-SPZ, prostatic secretory granules-PSGs, and seminal plasma-SP), as genetic, diet, and management ...
Dal Bosco, Alessandro, Collodel, Giulia, Mattioli, Simona, Castellini, Cesare   +3 more
core   +1 more source