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Imaging malformations of cortical development
2007Publisher Summary Cerebral cortical development is an extremely complex process, which may be divided into three broad sequential and overlapping steps of cell proliferation, neuronal migration, and cortical organization. The malformations of cortical development may result in the disruption of any of these events. This chapter describes the role and
Ingrid E B, Tuxhorn, Friedrich, Woermann
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Epilepsy and malformations of cortical development
Current Opinion in Neurology, 2015Malformations of cortical development (MCD) are increasingly recognized as causes of epilepsy and neurodevelopmental disorders. This review summarizes recent developments in the classification, specifically focusing on how genetic and cellular pathway advances are changing our understanding of MCD and how this applies to clinical care.Recent studies ...
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Malformations of Cortical Development
2013Malformations of cortical development are arranged in different ways. Recently, the ILAE published a consensus classification incorporating pathological, imaging, and genetic findings (Blumcke et al. 2011). Some lesions (namely FCD 2B) from this classification are clearly visible on MRI and pathologically classified with a high concordance between ...
Horst Urbach, Susanne Greschus
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Radiologic classification of malformations of cortical development
Current Opinion in Neurology, 2001Malformations of cerebral cortical development are common birth defects that can cause delayed development, epilepsy, focal neurologic deficits, and mental retardation. Rational classification of these disorders is essential for proper prognosis, genetic testing and counseling, and investigation of the underlying molecular causes.
A J, Barkovich +2 more
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Malformation of cortical development in adult patients
Epileptic Disorders, 2003Few studies have focused on the clinical, neurophysiological and prognostic features of adult epileptic patients with malformation of cortical development. We reviewed the clinical data of a series of sixty adult epileptic patients with different types of malformation of cortical development, who had been followed at the Epilepsy Centre of the ...
Paolo, Tinuper +6 more
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Microlissencephaly: A Heterogeneous Malformation of Cortical Development
Neuropediatrics, 1998We report the neonatal courses, early postnatal development, and neuroimaging findings of 17 patients with marked microcephaly and simplified cerebral gyral patterns, a condition that we call microlissencephaly. Retrospective analyses of the clinicoradiologic features of these patients allowed segregation of the patients into 5 distinct groups with ...
Barkovich, A J +6 more
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X-linked malformations of cortical development
American Journal of Medical Genetics, 2000Disorders of the development of the human cortex are recognized as significant causes of mental retardation, epilepsy, and congenital neurologic deficits. These malformations may be restricted to the brain or may be one component of a generalized malformation syndrome.
R J, Leventer, P L, Mills, W B, Dobyns
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Surgery for hemispheric malformations of cortical development
Neurosurgery Clinics of North America, 2002The treatment of patients with hemispheric malformations of cortical development presents a challenging clinical problem that often requires surgical intervention. The development of a safe and effective treatment strategy for these patients requires an extensive work-up with a great deal of attention to a variety of multidisciplinary testing methods ...
Eldad J, Hadar, William E, Bingaman
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Neuroimaging of Focal Malformations of Cortical Development
Journal of Clinical Neurophysiology, 1996Neuroimaging is playing an increasingly important role in the evaluation of patients with malformations of cerebral cortical development. In this review, the authors address optimal neuroimaging of cortical malformations using x-ray computed tomography, single-photon-emission computed tomography, positron emission tomography, magnetic resonance imaging,
A J, Barkovich, R I, Kuzniecky
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Functional neuroimaging of malformations of cortical development
Epileptic Disorders, 2003ABSTRACT Functional neuroimaging over the past 10 years has led to greater insights into the pathophysiology underlying symptomatic epilepsy. Such imaging has been used to localize cerebral dysfunction, predominantly through disturbances in metabolism or blood flow.
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