Results 51 to 60 of about 2,561,752 (294)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Determination of Predominant Organic Acid Components in Malus Species: Correlation with Apple Domestication

Metabolites, 2018
Significant variation in organic acid components was detected in mature fruits of 101 apple accessions using high-performance liquid chromatography. The Malus species predominantly accumulated malic acid and citric acid, whereas wild fruits exhibited ...
Baiquan Ma, Yangyang Yuan, Meng Gao, Cuiying Li, Collins Ogutu, Mingjun Li, Fengwang Ma   +6 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Supporting data for "4-Carboalkoxylated Polyvalerolactones from Malic Acid: Tough and Degradable Polyesters"

, 2019
Each type of data is collected in a single master folder (e.g., NMR spectra, SEC chromatograms, etc.) and then segregated into separate folders.Eight 4-carboalkoxyvalerolactones (CRVLs), varying in the composition of their alkyl (R) side chains, were ...
Hillmyer, Marc, De Hoe, Guilhem, Fahnhorst, Grant, Hoye, Thomas   +3 more
core   +1 more source

Effects of Malic Acid and Sucrose on the Fermentation Parameters, CNCPS Nitrogen Fractions, and Bacterial Community of Moringa oleifera Leaves Silage

Microorganisms, 2021
The present study investigated the effects of malic acid, sucrose, and their mixture on the fermentation parameters, Cornell Net Carbohydrate and Protein System (CNCPS) nitrogen fractions, and bacterial community of Moringa oleifera leaves (MOL) silages.
Hanchen Tian, Yue Wang, Zichong Liu, Zhaoying Hu, Yongqing Guo, Ming Deng, Guangbin Liu, Baoli Sun   +7 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Dietary Malic Acid Supplementation Induces Skeletal Muscle Fiber-Type Transition of Weaned Piglets and Further Improves Meat Quality of Finishing Pigs

Frontiers in Nutrition, 2022
The aim of this study was to investigate effects of dietary malic acid supplementation on skeletal muscle fiber-type transition during nursery period and the subsequent meat quality of finishing pigs. Results showed that malic acid supplementation for 28
Xin Zhang, Meixia Chen, Enfa Yan, Yubo Wang, Chenghong Ma, Pengguang Zhang, Jingdong Yin   +6 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Extracção de materiais de plataforma de biorrefinaria com líquidos iónicos [PDF]

, 2010
Mestrado em Materiais Derivados de Recursos RenováveisO crescimento económico sustentável requer a garantia de recursos para a produção industrial.
Oliveira, Filipe Serrão Santos
core  

Asymmetric Synthesis of Optically Active Malic Acid [PDF]

, 1996
Chiral reduction of 2-oxosuccinic acid esters with fermenting bakers' yeast gave (S)-(-)- malic acid esters in 34-54% isolated yield with 85-100 ...
Ono, Shin-ichiro, Utaka, Masanori, Tsuboi, Sadao   +2 more
core   +1 more source