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Archives of Surgery, 1959 The malignant carcinoid syndrome is manifested by (1) paroxysmal flushing, (2) chronic diarrhea, (3) respiratory distress, and (4) valvular heart disease. These abnormalities result from a marked increase in the amount of circulating serotonin. The abnormal clinical findings in this syndrome result principally from the action of serotonin on the ...
Wilson, Harwell, Storer, Edward H.
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Therapy of the Malignant Carcinoid Syndrome
Annals of Internal Medicine, 1965 Excerpt The therapy of the malignant carcinoid syndrome presents a unique challenge to physicians caring for patients with this unusual disease.
Charles E. Mengel
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Results of Pharmacologic Treatment in the Malignant Carcinoid Syndrome
New England Journal of Medicine, 1962 THE patient with the malignant carcinoid syndrome is confronted with a group of uncomfortable and debilitating symptoms. These may include recurrent acute flushing, colicky abdominal pains, violent and profuse watery diarrhea, tachycardia, asthma-like wheezing and, less often, profound weakness, depression or agitation, dyspnea and dependent edema ...
Alvin L. Ureles +2 more
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Effect of Melphalan in the Malignant Carcinoid Syndrome
Archives of Internal Medicine, 1969 Nine trials of the antitumor chemotherapeutic agent, melphalan (L-phenylalanine mustard; Alkeran) were carried out in eight patients with the malignant carcinoid syndrome. In six trials, this drug was given on a low-dose, daily basis. In three of these trials, there was definite evidence of antitumor effect as determined by measurable decreases in ...
Charles A. Lotito, Charles E. Mengel
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Malignant carcinoid syndrome treated by resection of hepatic metastases
The American Journal of Surgery, 1965 Summary Resection of metastatic carcinoid tumors in the liver resulted in complete immediate remission of incapacitating symptoms of the malignant carcinoid syndrome in a patient who had primary carcinoid tumor of the lung. * *Addendum: Nine months after resection of hepatic metastases, mild flushing attacks recurred.
James H. Foster, James J. Chandler
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Metastatic Carcinoid Tumors and the Malignant Carcinoid Syndrome [PDF]
Annals of the New York Academy of Sciences, 1994 Patients with metastatic carcinoid tumors and the malignant carcinoid syndrome have benefited immensely from diagnostic and therapeutic advances during the past decade. Magnetic resonance imaging and whole body scintigraphy with radiolabelled analogues of somatostatin have improved our ability to diagnose, detect, stage and follow response to therapy ...
L. Kvols
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Treatment of the carcinoid tumor and the malignant carcinoid syndrome.
Journal of Clinical Oncology, 1983Certainly in treatment of the carcinoid tumor surgery has a well-established curative and palliative potential. The primary challenge is a knowledgable marriage between stage of disease and aggressiveness of operative procedure. Nonsurgical treatment of the malignant disease per se has thus far not produced optimum results and, in the opinion of this ...
C. Moertel
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Cutaneous manifestations of the malignant carcinoid syndrome
British Journal of Dermatology, 2005The incidence of carcinoid tumours is approximately 1.5 per 100 000 of the population. The malignant carcinoid syndrome, which is caused by circulating neuroendocrine mediators produced by the tumour, occurs in less than 10% of patients. Cutaneous involvement, although recognized in this rare syndrome, has rarely been reported.To examine a series of ...
H.K. Bell +3 more
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Therapy of the Malignant Carcinoid Syndrome
Endocrinology and Metabolism Clinics of North America, 1989Although usually associated with carcinoid tumors of the small intestine that have metastasized to the liver, the carcinoid syndrome is seen less frequently with primary tumors arising from other organs such as the lung, pancreas, thymus, stomach, and ovary.
L. Kvols
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Journal of Clinical Oncology, 1989
Twenty-seven patients with metastatic carcinoid tumor, 24 of whom had the malignant carcinoid syndrome, were treated with recombinant leukocyte A interferon at a planned dose of 24 x 10(6) U/m2. Twenty percent of patients with measurable tumor experienced an objective regression and 39% of those with the carcinoid syndrome experienced a reduction of ...
Charles G. Moertel +2 more
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Twenty-seven patients with metastatic carcinoid tumor, 24 of whom had the malignant carcinoid syndrome, were treated with recombinant leukocyte A interferon at a planned dose of 24 x 10(6) U/m2. Twenty percent of patients with measurable tumor experienced an objective regression and 39% of those with the carcinoid syndrome experienced a reduction of ...
Charles G. Moertel +2 more
openaire +4 more sources