Results 31 to 40 of about 57,983 (265)

Variants in ASPH cause exertional heat illness and are associated with malignant hyperthermia susceptibility

Nature Communications, 2022
The genetic cause(s) of malignant hyperthermia and exertional heat illness are unknown in approximately 30% of cases. To address this barrier, the authors performed genome sequencing on a large cohort of cases, identifying rare variants in ASPH, a gene ...
Yukari Endo, Linda Groom, Alper Celik, Natalia Kraeva, Chang Seok Lee, Sung Yun Jung, Lois Gardner, Marie-Anne Shaw, Susan L. Hamilton, Philip M. Hopkins, Robert T. Dirksen, Sheila Riazi, James J. Dowling   +12 more
doaj   +1 more source

Hyperthermia combined with chemotherapy - Biological rationale, clinical application, and treatment results [PDF]

, 1999
There is substantial evidence from preclinical data that the antitumor cytotoxicity of selected chemotherapeutic agents either alone or combined with radiation can be enhanced by appropriate heat exposure (40-44 degrees C) of cells or tumor tissues ...
Issels, Rolf-Dieter
core   +1 more source

BEV-IP : perioperative chemotherapy with bevacizumab in patients undergoing cytoreduction and intraperitoneal chemoperfusion for colorectal carcinomatosis [PDF]

, 2015
Background: Selected patients with peritoneal carcinomatosis (PC) from colorectal cancer (CRC) benefit from cytoreductive surgery (CRS) combined with intraperitoneal chemoperfusion (IPC).
Ceelen, Wim, Liberale, Gabriel, Van Der Speeten, Kurt, Willaert, Wouter   +3 more
core   +2 more sources

Research progress of hyperthermia in tumor therapy by influencing metabolic reprogramming of tumor cells

International Journal of Hyperthermia, 2023
Cellular metabolic reprogramming is an important feature of malignant tumors. Metabolic reprogramming causes changes in the levels or types of specific metabolites inside and outside the cell, which affects tumorigenesis and progression by influencing ...
Yuchuan Yang, Linkuan Huangfu, Huizhen Li, Daoke Yang   +3 more
doaj   +1 more source

Malignant Hyperthermia Like Manifestations during Management of Refractory Status Epilepticus

Journal of Neuroanaesthesiology and Critical Care, 2023
Management of refractory status epilepticus is challenging for a neurointensivist consequent to systemic complexities associated with various drugs and modalities involved in its treatment.
Deepti Srinivas, Venkatesh Keshavan, Vikram Kamath, Manju Manmadhan   +3 more
doaj   +1 more source

Anesthesia for muscle biopsy to test susceptibility to malignant hyperthermia [PDF]

Revista Brasileira de Anestesiologia, 2019
Introduction Malignant hyperthermia is an autosomal dominant pharmacogenetic disorder, characterized by hypermetabolic crisis triggered by halogenated anesthetics and/or succinylcholine.
Helga Cristina Almeida da Silva, Elton Shinji Onari, Isac de Castro, Marcelo Vaz Perez, Alexandre Hortensi, José Luiz Gomes do Amaral   +5 more
doaj   +3 more sources

Isoflurane Induced Malignant Hyperthermia in a Patient with Glucose 6-Phosphate Dehydrogenase Deficiency and Growth Hormone Abuse

Case Reports in Anesthesiology, 2020
Malignant hyperthermia is a pharmacogenetic disorder in the regulation of calcium in skeletal muscles which is related to an uninhibited muscle hypermetabolic reaction to potent inhalation agents, the depolarizing muscle relaxant succinylcholine, and to ...
Hojatolah Ravaei, Mohammad Javad Yavari Barhaghtalab, Vahid Salehi, Hossein Hejr   +3 more
doaj   +1 more source

Postoperative Malignant Hyperthermia-A Medical Emergency: A Case Report and Review of Literature [PDF]

Journal of Clinical and Diagnostic Research, 2017
Malignant hyperthermia is a rare life threatening pharmacological disorder. Preoperative clinical diagnosis is not possible. Due to its rarity and severity, it must be taken as an important differential diagnosis for postoperative hyperthermia.
Amit Kumar Sinha, Poonam Kumari, Maheshkumar Manilal Vaghela, Chandni Sinha, Bindey Kumar   +4 more
doaj   +1 more source

Electro-hyperthermia in Oncology [PDF]

, 2001
Hyperthermia is a rapidly developing treatment method in oncology. The classical effect is based on well-focused energy absorption targeting the malignant tissue.
Szász, András, Szász, Nóra, Szász, Olivér   +2 more
core  

Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration

Advanced Materials Technologies, EarlyView.
This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley   +1 more source