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Postgraduate Medical Journal, 1998 SummaryMalignant hyperthermia is a rare autosomal dominant trait that predisposes affected individuals to great danger when exposed to certain anaesthetic triggering agents (such as potent volatile anaesthetics and succinylcholine). A sudden hypermetabolic reaction in skeletal muscle leading to hyperthermia and massive rhabdomyolysis can occur.
R, Ben Abraham +3 more
openaire +4 more sources
Frontiers in Physiology, 2021 Aging causes skeletal muscles to become atrophied, weak, and easily fatigued. Here, we have tested the hypothesis that normal aging in skeletal muscle cells is associated with Ca2+ intracellular dyshomeostasis and oxidative stress.
Alfredo Mijares +2 more
doaj +1 more source
eLife, 2020 Most glucose is processed in muscle, for energy or glycogen stores. Malignant Hyperthermia Susceptibility (MHS) exemplifies muscle conditions that increase [Ca2+]cytosol. 42% of MHS patients have hyperglycemia.
Eshwar R Tammineni +7 more
doaj +1 more source
BMC Anesthesiology, 2020 Background The cost-benefit of stocking dantrolene in maternity units for treating malignant hyperthermia (MH) has been recently questioned because of the low incidence of MH crisis in the general population and the low utilization of general anesthesia ...
Jean Guglielminotti +2 more
doaj +1 more source
Functional effects of mutations in the skeletal muscle ryanodine receptor type 1 (RYR1) linked to malignant hyperthermia and central core disease [PDF]
, 2006 Malignant hyperthermia (MH) is a pharmacogenetic disorder with autosomal dominant inheritance. In susceptible individuals, a MH crisis may be triggered by commonly used halogenated anaesthetics (halothane, isoflurane) or muscle relaxants ...
Ducreux, Sylvie
core +1 more source
European Journal of Translational Myology, 2016 We have compared the ultrastructure of skeletal muscle biopsies from patients that have survived a [Malignant Hyperthermia, MH] episode and siblings that test positive for MH susceptibility with those from siblings that tested negatives.
Manuela Lavorato +3 more
doaj +1 more source
Hyperthermia combined with chemotherapy - Biological rationale, clinical application, and treatment results [PDF]
, 1999 There is substantial evidence from preclinical data that the antitumor cytotoxicity of selected chemotherapeutic agents either alone or combined with radiation can be enhanced by appropriate heat exposure (40-44 degrees C) of cells or tumor tissues ...
Issels, R.D., Issels, Rolf-Dieter
core +1 more source
Calcium homeostasis and role of ryanodine receptor type 1 (RyR1) in immune cells [PDF]
, 2010 Ryanodine receptors are intracellular Ca2+ release channels located in the membrane of the Endoplasmatic/Sarcoplasmatic Reticulum. Ryanodine receptor 1 isoform is preferentially expressed in skeletal muscle where it is responsible for release of Ca2 ...
Vukcevic, Mirko
core +1 more source
Malignant hyperthermia: A case report
Human Pathology Reports, 2023 Malignant hyperthermia is a rare hypermetabolic pharmacogenetic pathologic disorder of calcium release control in skeletal muscle following exposure to depolarizing muscle relaxants and inhalational anesthetics in general anesthesia.
Fereshteh Amiri +2 more
doaj +1 more source
Effect of hyperthermia on prognosis after acute ischemic stroke [PDF]
, 2009 <p><b>Background and Purpose:</b> Experimental studies have shown that hyperthermia is a determinant of poor outcome after ischemic stroke.
Lees, K.R. +4 more
core +1 more source