Results 51 to 60 of about 2,304,945 (294)

Malignant Transformation of Meningiomas

Journal of Cancer
Meningioma is the most common intracranial tumor. Sometimes, meningiomas can develop malignant transformation (MT). In this review, we review the incidence of MT of meningiomas. The incidence of MT of grade 2 meningiomas is likely to be higher than benign meningiomas.
Yu, Jinxiu, Deng, Jiaojiao, Ren, Leihao, Hua, Lingyang, Gong, Ye   +4 more
openaire   +2 more sources

A mathematical model describes the malignant transformation of low grade gliomas: Prognostic implications. [PDF]

, 2017
Gliomas are the most frequent type of primary brain tumours. Low grade gliomas (LGGs, WHO grade II gliomas) may grow very slowly for the long periods of time, however they inevitably cause death due to the phenomenon known as the malignant transformation.
Víctor M. Pérez-García, Bogdańska, Magdalena U, Philippe Schucht, Monika J Piotrowska, Víctor M Pérez-García, Monika J. Piotrowska, Schucht, Philippe, Bogdańska, Magdalena, Beck, Jürgen, Piotrowska, Monika J, Michael Murek, Piotrowska, Monika, Bodnar, Marek, Martínez-González, Alicia, Magdalena U. Bogdańska, Murek, Michael, Pérez-García, Víctor M, Jürgen Beck, Alicia Martínez-González, Pérez-García, Víctor M., Magdalena U Bogdańska, Marek Bodnar   +21 more
core   +3 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Malignant Transformation of an Intracranial Extradural Epidermoid Cyst into Squamous Cell Carcinoma Presented with Cerebrospinal Fluid Leakage

Advanced Biomedical Research, 2017
We report a case of malignant transformation of an intracranial extradural epidermoid cyst into squamous cell carcinoma (SCC), that presented with cerebrospinal fluid (CSF) leakage at the time of recurrence.
Bahram Seif, Reza Pourkhalili, Ahmad Shekarchizadeh, Parvin Mahzouni   +3 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Inverted papilloma: a single institution experience with 91 cases

B-ENT, 2019
Objectives: Inverted papilloma is a benign tumor associated with local aggressiveness, high rates of recurrence, and possible malignant transformation. The probability of malignant transformation and recurrence rates are difficult to estimate because of ...
I. Kelava, M. V. Grgić, H. Čupić, M. Ries, T. Gregurić, A. Hazurović, V. Bedeković   +6 more
doaj   +2 more sources

Genotoxicity-Stimulated and CYLD-Driven Malignant Transformation

Cancer Management and Research, 2022
Adnan Erol Independent Researcher, Istanbul, TurkeyCorrespondence: Adnan Erol, Email eroladnan@protonmail.comAbstract: Oxidative stress, which can cause DNA damage, can both activate TNF-R1 directly in the absence of TNF stimulation and phosphorylate c ...
Erol A
doaj  

Malignant transformation of oral leukoplakia: a retrospective cohort study of 218 Chinese patients

BMC Cancer, 2010
Background Oral leukoplakia (OL) is the best-known potentially malignant disorder. A new binary system to grade dysplasia was proposed by WHO, but the biological significance in predicting malignant transformation risk is unknown.
Zhou Zeng-Tong, Shi Peng, Zhou Hai-Wei, Wang Yu-Feng, Liu Wei, Tang Guo-Yao   +5 more
doaj   +1 more source