Results 31 to 40 of about 1,172,080 (268)

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Efficacy and influencing factors of bevacizumab monotherapy and combination therapy in recurrent high-grade glioma: a twelve-year experience

BMC Neurology
Background Gliomas are the most prevalent primary malignant brain tumors in adults, with high-grade gliomas (HGGs) characterized by elevated recurrence rates, aggressiveness, and mortality.
Hai Wang, Wenlin Chen, Yixuan Song, Yaning Cao, Xiaopeng Guo, Ling Zhang, Xin Zhang, Yulu Ge, Junlin Li, Yilin Li, Xiaoman Kang, Jiahui Liu, Yijun Dong, Zihan Zhong, Shanmu Jin, Qianshu Liu, Yu Wang, Wenbin Ma   +17 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The molecular signature and prognosis of glioma with preoperative intratumoral hemorrhage: a retrospective cohort analysis

BMC Neurology
Background Intratumoral hemorrhage, though less common, could be the first clinical manifestation of glioma and is detectable via MRI; however, its exact impacts on patient outcomes remain unclear and controversial.
Yixin Shi, Xiaoman Kang, Yulu Ge, Yaning Cao, Yilin Li, Xiaopeng Guo, Wenlin Chen, Siying Guo, Yaning Wang, Delin Liu, Yuekun Wang, Hao Xing, Yu Xia, Junlin Li, Jiaming Wu, Tingyu Liang, Hai Wang, Qianshu Liu, Shanmu Jin, Tian Qu, Huanzhang Li, Tianrui Yang, Kun Zhang, Feng Feng, Yu Wang, Hui You, Wenbin Ma   +26 more
doaj   +1 more source

Translocations in Malignant Tumors [PDF]

The American Journal of Pathology, 2001
In general, the development and biology of epithelial tumors, carcinomas, and adenocarcinomas are associated with an array of orchestrated genetic changes characterized by a successive process of loss of heterozygosity. On the other hand, tumors of mesodermal origin (bone and soft tissue tumors) are often associated with translocations thought to be ...
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Integrative analysis of thiamethoxam induced hepatocellular carcinoma toxicity mechanisms

Scientific Reports
Neonicotinoid (NEO) pesticides play a crucial role in agricultural production. However, their potential risks to human health and the environment cannot be overlooked.
Chenghao Wang, Zhichao Wang, Yinqin Hu, Shi Xiang, Hui Chen, Chao Yang   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Navel orange peel essential oil inhibits the growth and progression of triple negative breast cancer

BMC Complementary Medicine and Therapies
Background Triple Negative Breast Cancer (TNBC) is a particular type of breast cancer with the highest mortality rate. Essential oils are concerned more and more as potential anti-cancer drugs.
Chao Yang, Wenwen Zhang, Shi Xiang, Lai Chen, Jiong Chun, Hui Chen   +5 more
doaj   +1 more source