Results 11 to 20 of about 34,795 (237)

Smiles‐Truce Cascades Enable Heteroaryl Cyclopropane and Sultine Synthesis

Angewandte Chemie, EarlyView.
A triple C─C cascade approach to the synthesis of heteroaryl cyclopropanes is described. The reaction is metal‐free, uses simple starting materials, and presents a new retrosynthetic approach for heteroaryl cyclopropane synthesis. A change of substituent creates a new route to sultines, under‐explored motifs in medicinal chemistry. Abstract We describe
Thomas Sephton, Zi Liu, Michael F. Greaney   +2 more
wiley   +2 more sources

Well-defined silica-supported olefin metathesis catalysts [PDF]

, 2009
Two triethoxysilyl-functionalized N-heterocyclic carbene ligands have been synthesized and used to prepare the corresponding second-generation ruthenium olefin metathesis catalysts.
Allen, Daryl P., Grubbs, Robert H., Van Wingerden, Matthew M.   +2 more
core   +1 more source

Cronobacter, the emergent bacterial pathogen Enterobacter sakazakii comes of age; MLST and whole genome sequence analysis [PDF]

, 2014
Background: Following the association of Cronobacter spp. to several publicized fatal outbreaks in neonatal intensive care units of meningitis and necrotising enterocolitis, the World Health Organization (WHO) in 2004 requested the establishment of a ...
Dickins, B, Forsythe, SJ, Jolley, KA
core   +2 more sources

The Role of HINT3 in Myocardial Ischemia‐Reperfusion Injury in Male Mice: Mechanisms Involving SDHA and its Acetylation

Advanced Science, EarlyView.
HINT3 expression declines after myocardial ischemia‐reperfusion injury. In male mice, loss of HINT3 worsens cardiac injury and mitochondrial dysfunction, while its overexpression is protective. HINT3 binds the mitochondrial enzyme succinate dehydrogenase (SDHA) and prevents its deacetylation by histone deacetylase 1 (HDAC1), reducing succinate ...
Jiabin Yu, Qi Yao, Tongtong Hu, Yadan Zhang, Ying Liu, Yang Xiao, Qingqing Wu, Qizhu Tang   +7 more
wiley   +1 more source

Chemoenzymatic Route toward a De Novo Enantioselective Total Synthesis of (S)-Baclofen Based on Metal-Catalyzed Hydroformylation and Enzymatic Transamination. [PDF]

Chembiochem
A unique chemoenzymatic synthesis route toward (S)‐baclofen is presented, which highlights a hydroformylation and biocatalysis step toward the synthesis of such a challenging β‐chiral amino acid. The shown methodology exhibits high conversions and enantiomeric excess and is transferable to other β‐chiral amines and amino acids.
Belov F, Bork H, Hänel L, Kollipara MV, Höhne M, Gröger H, von Langermann J.   +6 more
europepmc   +2 more sources

Preparation, Characterization and Reactivity of (3-Methylpentadienyl)iron(1+) Cations [PDF]

, 2007
The title cations (9 and 12) were prepared by dehydration of (3-methyl-2,4-pentadien-1-ol)Fe(CO)2L+ complexes. The structure of the (CO)2PPh3-ligated 12 was determined by single-crystal X-ray analysis. Reaction of carbon and heteroatom nucleophiles to (3-
Bennett, Dennis W, Chaudhury, Subhabrata, Donaldson, William, Haworth, Daniel T., Li, Shukun, Siddiquee, Tasneem   +5 more
core   +1 more source

A Refined Adaptive Laboratory Evolution Strategy With Biosensor‐Assisted Selection Resolves the Tolerance–Efficiency Trade‐Off in Toxic Chemical Biosynthesis

Advanced Science, EarlyView.
This study presents a refined adaptive laboratory evolution (ALE) strategy to resolve the trade‐off between tolerance and biosynthetic efficiency in toxic chemical production. Combining in vivo mutagenesis, microdroplet‐based evolution, and biosensor‐assisted selection, this strategy rapidly yields robust “win‐win” phenotypes.
Yufei Zhang, Junhua Yun, Guoyan Zhang, Hossain M. Zabed, Yuehui Tian, Xinrui Tang, Jia Li, Xianghui Qi   +7 more
wiley   +1 more source

Nucleophilic Addition to (3-Methylpentadienyl)iron(1+) Cations: Counterion Control of Regioselectivity; Application to the Enantioselective Synthesis of 4,5-Disubstituted Cyclohexenones [PDF]

, 2006
The regioselectivity of malonate addition to (3-methylpentadienyl)Fe(CO)3+ is controlled by the malonate−counterion association. The Li+ salt of malonate proceeds via C1 nucleophilic attack to afford the 1,3Z-diene complex 4a, while reaction of highly ...
Chaudhury, Subhabrata, Donaldson, William   +1 more
core   +1 more source

Catalytic Activity of Solution Additive Anions for Magnesite and Calcite Precipitation in Microwave‐Assisted Mineral Carbonation Experiments

Advanced Energy and Sustainability Research, EarlyView.
Demonstrating anion‐catalyzed CO2 mineralization and microwave‐boosted carbonation, this study advances sustainable carbon capture and utilization technologies, mitigating climate change by promoting efficient magnesite and calcite precipitation from eco‐friendly processes.
Marcello Campione, Daniela D’Alessio, Mattia Corti, Giancarlo Capitani, Andrea Lucotti, Matteo Tommasini, Rossella Yivlialin, Lamberto Duò, Gianlorenzo Bussetti, Nadia Malaspina   +9 more
wiley   +1 more source

On the role of the oxidation in the methylation of guanidoacetic acid [PDF]

, 1947
There are two, at least, methyl transfer reactions promoted by liver slices in vitro (2).
Borsook, Henry, Dubnoff, Jacob W.
core