Results 41 to 50 of about 34,795 (237)

Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function

European Journal of Heart Failure, EarlyView.
Improving clinical translation of mitoprotective therapies. 31P MRI, phosphorus‐31 magnetic resonance imaging; hiPSC‐CM, human‐induced pluripotent stem cell‐derived cardiomyocyte; IHD, ischaemic heart disease. Abstract Acute myocardial infarction (MI) remains a major cause of death and disability worldwide.
Melanie Paillard, Mahmoud Abdellatif, Ioanna Andreadou, Christian Bär, Luc Bertrand, Bianca J.J.M. Brundel, Gemma Chiva‐Blanch, Sean M. Davidson, Dana Dawson, Fabio Di Lisa, Paul Evans, Zoltan Giricz, Derek J. Hausenloy, Petra Kleinbongard, Frank Lezoualc'h, Elisa Liehn, Christoph Maack, Ange Maguy, Elizabeth Murphy, Cinzia Perrino, Maurizio Pesce, Peter P. Rainer, Katrin Streckfuss‐Bömeke, Matthias Thielmann, Rong Tian, Carlo G. Tocchetti, Jolanda Van Der Velden, Sophie Van Linthout, Serena Zacchigna, Thomas Krieg   +29 more
wiley   +1 more source

Metabolomic profiles are gender, disease and time specific in the interleukin-10 gene-deficient mouse model of inflammatory bowel disease. [PDF]

, 2013
Metabolomic profiling can be used to study disease-induced changes in inflammatory bowel diseases (IBD). The aim of this study was to investigate the difference in the metabolomic profile of males and females as they developed IBD.
Churchill, Thomas A, Doyle, Jason, Fedorak, Richard N, Foshaug, Rae R, Slupsky, Carolyn M, Sydora, Beate C, Tso, Victor K   +6 more
core   +2 more sources

A Fullerene‐Based Selenosugar Ball

European Journal of Organic Chemistry, EarlyView.
A fullerene hexakis‐adduct decorated with 12 peripheral seleno‐d‐talitol moieties is synthesized efficiently with a Th‐symmetry from a hexakis‐adduct of [60]fullerene prepared by a cycloaddition reaction and subsequent copper‐catalyzed azide‐alkyne cycloaddition click chemistry.
Reinier Lemos, Yoana Pérez‐Badell, Mauro De Nisco, Giovanna Cimmino, Claudia González, Andrea Carpentieri, Severina Pacifico, Margarita Suárez, Silvana Pedatella   +8 more
wiley   +1 more source

Nonproductive Events in Ring-Closing Metathesis Using Ruthenium Catalysts [PDF]

, 2010
The relative TONs of productive and nonproductive metathesis reactions of diethyl diallylmalonate are compared for eight different ruthenium-based catalysts. Nonproductive cross metathesis is proposed to involve a chain-carrying ruthenium methylidene.
Grubbs, Robert H., Keitz, Benjamin K., Kuhn, Kevin M., Stewart, Ian C., Thomas, Renee M.   +4 more
core   +2 more sources

Multicomponent Synthesis of Fluorine‐Containing Bioactive Compounds and Drugs

European Journal of Organic Chemistry, EarlyView.
Multicomponent reactions are robust synthetic tools to assamble complex polyheterocycles and other interesting molecular architectures with potential application in medicinal chemistry, including their fluorine‐containing analogues. Fluorine atoms placed strategically into bioactive molecules often enhance essential pharmacokinetic parameters like ...
Ivette Morales‐Salazar, Perla Islas‐Jácome, Leonardo D. Herrera‐Zuñiga, Samuel Couve‐Bonnaire, Philippe Jubault, Eduardo González‐Zamora, Jean‐Philippe Bouillon, Alejandro Islas‐Jácome   +7 more
wiley   +1 more source

Privileged Chiral Photocatalysts

Angewandte Chemie, Volume 137, Issue 36, September 1, 2025.
Privileged chiral catalysts have transformed asymmetric synthesis, conferring generality to processes that are routinely leveraged in the construction of societally important functional small molecules. This mini‐review is intended to survey the conception and evolution of privileged chiral photocatalyst scaffolds that enable simultaneous orchestration
Emanuel Studer, Smita Mandal, Timo Stünkel, Ryan Gilmour   +3 more
wiley   +2 more sources

A new purple sulfur bacterium from saline littoral sediments, Thiorhodotvibrio winogradskyi gen. nov. and sp. nov. [PDF]

, 1992
Two strains of a new purple sulfur bacterium were isolated in pure culture from the littoral sediment of a saline lake (Mahoney Lake, Canada) and a marine microbial mat from the North Sea island of Mellum, respectively.
BB Jørgensen, BB Jørgensen, C Kämpf, CLM Steenbergen, E Reynolds, E Siefert, EF Hartree, GA Horridge, GW Luther, H Gemerden van, J Overmann, JAM Nicholson, K Schmidt, M Meshbah, M Takahashi, N Pfennig, N Pfennig, N Pfennig, N Pfennig, PT Visscher, R Wit De, R Wit de, RM Cole, TB Parkin, TW Goodwin, W Bavendamm   +25 more
core   +1 more source

Trash‐to‐Energy: Shedding Light on Plastic and Biomass Valorization Through Artificial Photosynthesis Towards Sustainability

Exploration, EarlyView.
To engrave a circular economy, artificial photosynthesis emerges as a promising and prosperous strategy to upcycle solid waste into clean fuel and valuable chemicals for sustainable fuel production. This review highlights the design of photocatalysts and external‐field‐assisted photocatalysis for effective solid waste conversion toward an ...
Ke Ming Lim, Valerine Khoo, Wee‐Jun Ong   +2 more
wiley   +1 more source

Exploring the role of the α-carboxyphosphonate moiety in the HIV-RT activity of α-carboxy nucleoside phosphonates [PDF]

, 2016
As α-carboxy nucleoside phosphonates (α-CNPs) have demonstrated a novel mode of action of HIV-1 reverse transcriptase inhibition, structurally related derivatives were synthesized, namely the malonate 2, the unsaturated and saturated bisphosphonates 3 ...
Arnold, Eddy, Balzarini, Jan, Das, Kalyan, Ford, Alan, Maguire, Anita R., Maguire, Nuala M., Mullins, Nicholas D.   +6 more
core   +1 more source

Reversible Conjugate Addition in Thiol‐Mediated Uptake

Helvetica Chimica Acta, EarlyView.
In a firework of dynamic covalent Michael addition chemistry, unorthodox, sulfur−rich bissulf(ox)idoenone acceptors activate classical reversible cyanoacrylamide acceptors to record performances in thiol−mediated uptake and reveal two new, mechanistically distinct and selective dynamic covalent exchange cascades with cellular thiols to activate and ...
Yuheng Zhang, Giacomo Renno, Gustav J. Wørmer, Ahmad M. Tamr, Oliver Thorn‐Seshold, Thomas B. Poulsen, Naomi Sakai, Stefan Matile   +7 more
wiley   +1 more source