Results 11 to 20 of about 15,343 (225)

Smiles‐Truce Cascades Enable Heteroaryl Cyclopropane and Sultine Synthesis

Angewandte Chemie, EarlyView.
A triple C─C cascade approach to the synthesis of heteroaryl cyclopropanes is described. The reaction is metal‐free, uses simple starting materials, and presents a new retrosynthetic approach for heteroaryl cyclopropane synthesis. A change of substituent creates a new route to sultines, under‐explored motifs in medicinal chemistry. Abstract We describe
Thomas Sephton, Zi Liu, Michael F. Greaney   +2 more
wiley   +2 more sources

Rhodium-catalyzed arylative cyclization of alkynyl malonates by 1,4-rhodium(i) migration.

Chemical Communications, 2019
The synthesis of functionalized 1-tetralones by the rhodium(i)-catalyzed reaction of alkynyl malonates with arylboronic acids is described. These arylative cyclizations proceed via an alkenyl-to-aryl 1,4-Rh(i) migration as a key step. Preliminary results
Luke O'Brien, S. N. Karad, W. Lewis, H. Lam   +3 more
semanticscholar   +1 more source

The Role of HINT3 in Myocardial Ischemia‐Reperfusion Injury in Male Mice: Mechanisms Involving SDHA and its Acetylation

Advanced Science, EarlyView.
HINT3 expression declines after myocardial ischemia‐reperfusion injury. In male mice, loss of HINT3 worsens cardiac injury and mitochondrial dysfunction, while its overexpression is protective. HINT3 binds the mitochondrial enzyme succinate dehydrogenase (SDHA) and prevents its deacetylation by histone deacetylase 1 (HDAC1), reducing succinate ...
Jiabin Yu, Qi Yao, Tongtong Hu, Yadan Zhang, Ying Liu, Yang Xiao, Qingqing Wu, Qizhu Tang   +7 more
wiley   +1 more source

Redox-Annulations of Cyclic Amines with 2-(2-Oxoethyl)malonates.

Organic Letters, 2018
Amines such as 1,2,3,4-tetrahydroisoquinoline undergo redox-neutral annulations with 2-(2-oxoethyl)malonates in the presence of catalytic amounts of benzoic acid.
Zhengbo Zhu, H. Chandak, D. Seidel
semanticscholar   +1 more source

A Refined Adaptive Laboratory Evolution Strategy With Biosensor‐Assisted Selection Resolves the Tolerance–Efficiency Trade‐Off in Toxic Chemical Biosynthesis

Advanced Science, EarlyView.
This study presents a refined adaptive laboratory evolution (ALE) strategy to resolve the trade‐off between tolerance and biosynthetic efficiency in toxic chemical production. Combining in vivo mutagenesis, microdroplet‐based evolution, and biosensor‐assisted selection, this strategy rapidly yields robust “win‐win” phenotypes.
Yufei Zhang, Junhua Yun, Guoyan Zhang, Hossain M. Zabed, Yuehui Tian, Xinrui Tang, Jia Li, Xianghui Qi   +7 more
wiley   +1 more source

Catalytic Activity of Solution Additive Anions for Magnesite and Calcite Precipitation in Microwave‐Assisted Mineral Carbonation Experiments

Advanced Energy and Sustainability Research, EarlyView.
Demonstrating anion‐catalyzed CO2 mineralization and microwave‐boosted carbonation, this study advances sustainable carbon capture and utilization technologies, mitigating climate change by promoting efficient magnesite and calcite precipitation from eco‐friendly processes.
Marcello Campione, Daniela D’Alessio, Mattia Corti, Giancarlo Capitani, Andrea Lucotti, Matteo Tommasini, Rossella Yivlialin, Lamberto Duò, Gianlorenzo Bussetti, Nadia Malaspina   +9 more
wiley   +1 more source

Engineered Integration of Diverse Functional Units Induces Multifunctionality in Malonate‐Borate Hybrids

Aggregate, EarlyView.
Herein, we present a new crystal system by aggregating multifunctional malonate and boro‐oxygen units, which maintains short UV cutoff edges while exhibiting distinct functionalities, including large birefringence, strong SHG responses, and substantial ionic conductivity.
Ziqi Chen, Chenxu Li, Xiaoyu Wu, Juanjuan Lu, Zhihua Yang, Xueling Hou, Miriding Mutailipu   +6 more
wiley   +1 more source

Kupfer(II)‐photokatalysierte Radikalannellierung von Nitroalkanen mit Alkenen oder Alkinen zur Synthese von Isoxazolinen und Isoxazolen

Angewandte Chemie, EarlyView.
Wir stellen ein Cu(II)‐photokatalytisches Verfahren vor, bei dem handelsübliche Nitroalkane für die Synthese von Isoxazolinen und Isoxazolen aus Alkenen bzw. Alkinen verwendet werden. Detaillierte mechanistische Untersuchungen ergaben, dass der breite Substratbereich, der sowohl aktivierte als auch nicht aktivierte Alkene und Alkine umfasst, auf einen ...
Sunaina Sardana, Aryaman Pattanaik, Julia Rehbein, Oliver Reiser   +3 more
wiley   +1 more source

Copper(II)‐Photocatalyzed Radical Anellation of Nitroalkanes with Alkenes or Alkynes for the Synthesis of Isoxazolines and Isoxazoles

Angewandte Chemie International Edition, EarlyView.
We present a Cu(II)‐photocatalyzed method that employs commercially available nitroalkanes for the synthesis of isoxazolines and isoxazoles from alkenes and alkynes, respectively. Detailed mechanistic investigations revealed that the broad substrate scope, encompassing both activated and unactivated alkenes and alkynes, is attributable to a radical ...
Sunaina Sardana, Aryaman Pattanaik, Julia Rehbein, Oliver Reiser   +3 more
wiley   +1 more source

Indole Synthesis via Allenyl Ester; Enantioselective Total Synthesis of Geissoschizoline

ChemistryEurope, EarlyView.
An indole synthesis via an allenyl ester intermediate at ambient temperature has been developed. The mild reaction conditions allow the use of a broad range of substrates. Notably, the utility of this approach is demonstrated through the asymmetric total synthesis of geissoschizoline, a Strychnos‐type monoterpenoid indole alkaloid.
Sohsuke Moriue, Honami Nishioka, Yuto Fukuda, Hiromitsu Takayama, Mariko Kitajima, Hayato Ishikawa   +5 more
wiley   +1 more source