Results 31 to 40 of about 1,395 (183)
A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior
Advanced Science, EarlyView.Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li +12 more
wiley +1 more source
Advanced Science, EarlyView.Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong +13 more
wiley +1 more source
Photoelectrocatalytic Diazidation of Olefins via Synergistic Dual Iron Species
Advanced Science, EarlyView.We report a simple and general approach for 1,2‐diazidation of alkenes by a photoelectrochemical strategy using TMSN3 as an azide source. This transformation proceeds using earth‐abundant iron under mild reaction conditions. It displays broad functional group compatibility and accommodates diverse alkene types‐including unactivated, activated, electron‐
Zhi‐Peng Guan +6 more
wiley +1 more source
IUCrJ, 2018 Photoinitiated solid-state reactions are known to affect the physical properties of coordination polymers, such as fluorescence and sorption behaviour, and also afford extraordinary architectures (e.g. three-periodic structures with polyorganic ligands).
Ekaterina N. Zorina-Tikhonova +10 more
doaj +1 more source
Advanced Science, EarlyView.MG‐1 is a bifunctional small molecule that enhances the removal of damaged mitochondria through autophagy, the cell's recycling pathway. Its activity increases under mitochondrial stress, with minimal effects on basal autophagy. MG‐1 also improves movement in a zebrafish model of mitochondrial dysfunction, supporting further investigation of this ...
Ratislav M. Ozhiganov +24 more
wiley +1 more source
SynOpen, 2017 α-Aryl malonate and α-aryl cyano acetate moieties are found in the structures of many bioactive compounds. They are also key intermediates for the synthesis of many compounds such as isoflavonoids.
José F. Cívicos +2 more
doaj +1 more source
On the Metabolism of Malonate and Malonate Decarboxylase Activity in Pseudomonas sp.
Journal of the agricultural chemical society of Japan, 1974 1. Ps. avalis IAM 1177およびPs. fluorescens AT CC 11250を用いて,マロン酸脱炭酸酵素について検討した. 2. 供試菌は培地中に著量の炭酸ガスを放出しながら,マロン酸を炭素源としてよく利用した.菌体にとり込まれたマロン酸の炭素は,他の菌体成分にくらべていちじるしく高く脂質区分に検出された. 3. マロン酸脱炭酸酵素はマロン酸によって誘導されグルコースやリンゴ酸などの炭素源によって強く抑制された.また,メチルマロン酸およびエチルマロン酸にも弱い誘導作用が認められた. 4. Ps. avalisから約16倍に部分精製した酵素標品では,マロン酸のほかにメチルマロン酸が基質となることが認められた. 5.
TAKAMURA, Yoshichika +2 more
openaire +2 more sources
Angewandte Chemie International Edition, EarlyView.A manganese single‐atom photocatalyst on functionalised carbon nitride enables selective visible‐light‐driven C(sp2)─H chlorination. DFT‐supported mechanistic studies indicate that photoinduced charge separation activates NCS, while isolated Mn sites stabilize Mn─Cl intermediates at the catalyst interface.
Jaro Vanderghinste +16 more
wiley +1 more source
European Journal of Organic Chemistry, EarlyView.Quinine‐catalyzed enantioselective conjugate addition of malononitrile derivatives to enynes provides trisubstituted chiral allenes in good to excellent yields and high enantiopurities under mild conditions. Broad substrate scope, easy scalability, and versatile post‐synthetic transformations into enantioenriched pyrazoles and furans highlight the ...
Martin Kamlar +3 more
wiley +1 more source
Cycloaddition Reactions of Alkynyl‐[2.2]paracyclophanes Toward Fluorenone and Benzene Analogs
European Journal of Organic Chemistry, EarlyView.Cycloaddition reactions of ethynyl [2.2]paracyclophane and methyl 3‐( [2.2]paracyclophan‐2‐yl)propynoate were studied under different conditions. Catalytic cyclotrimerization of the former gave rise to the 2‐aryl‐[2.2]paracyclophanes. Diels–Alder reaction of the latter with tetramethylcyclobutadiene‐AlCl3 adduct furnished Dewar benzenes that were ...
Stefanie Magela Perdomo +4 more
wiley +1 more source