Results 91 to 100 of about 165,269 (210)

Regulation of TORC2 function and localization by Rab5 GTPases in Saccharomyces cerevisiae. [PDF]

, 2019
The evolutionarily conserved Target of Rapamycin (TOR) complex-2 (TORC2) is an essential regulator of plasma membrane homeostasis in budding yeast (Saccharomyces cerevisiae).
Locke, Melissa N, Thorner, Jeremy
core   +1 more source

Huge soft tissue PEComa with aggressive lung and bone metastases

Journal of Cancer Research and Practice, 2017
Perivascular epithelioid cell tumors (PEComas) are uncommon mesenchymal tumors characterized by the presence of both myogenic and melanocytic markers, and huge soft tissue PEComas are even rarer.
Shih-Hao Tang, Yi-Chang Liu, Hui-Hua Hsiao, Shih-Feng Cho, Yu-Fen Tsai, Hui-Ching Wang, Sheng-Fung Lin, Ta-Chih Liu   +7 more
doaj   +1 more source

Phosphatidylinositol-3 kinase-Akt-mammalian target of rapamycin signaling pathway mediates contractility of human endometriotic stromal cells: A promising new target for the treatment of endometriosis-associated fibrosis

Gynecology and Minimally Invasive Therapy, 2014
Objective: To assess the involvement of phosphatidylinositol-3 kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) on the extracellular matrix contractility of endometriotic cells.
Wakana Abe, Kaei Nasu, Akitoshi Tsuno, Yukie Kawano, Hisashi Narahara   +4 more
doaj   +1 more source

mTOR-inhibiting pharmacotherapy for the treatment of non-infectious uveitis: a systematic review protocol

Systematic Reviews, 2018
Background Non-infectious uveitis represents a sub-type of intraocular inflammation often associated with disorders of immune dysregulation. If untreated, the intraocular inflammation may progress to severe visual impairment and blindness.
Joshua Blair, Robert Barry, Philip I. Murray, David J. Moore, Alastair K. Denniston   +4 more
doaj   +1 more source

mammalian target of rapamycin

Citation: 'mammalian target of rapamycin' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13436 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual ...
openaire   +1 more source

Unraveling the function of TSC1-TSC2 complex: implications for stem cell fate

Stem Cell Research & Therapy
Background Tuberous sclerosis complex is a genetic disorder caused by mutations in the TSC1 or TSC2 genes, affecting multiple systems. These genes produce proteins that regulate mTORC1 activity, essential for cell function and metabolism.
Shuang Wang, Ruishuang Ma, Chong Gao, Yu-Nong Tian, Rong-Gui Hu, Han Zhang, Lan Li, Yue Li   +7 more
doaj   +1 more source

Comparing In-Vitro Effects of Two Immunosuppressive Drugs on the Expression of Foxp3 from Naïve CD4+ T Cells

مجله دانشکده پزشکی اصفهان, 2015
Background: Many studies showed that regulatory T cells (Tregs) have immunosuppressive effects on immune responses in transplantation and autoimmune disease.
Serineh Shajanian, Marjan Gharagozloo, Mazak Ganjalikhani-Hakemi, Mitra Rafiee   +3 more
doaj  

Systemic Therapy in Endometrial Cancer: Recent Advances. [PDF]

, 2013
Endometrial cancer is a chemosensitive disease. Studies have established a clear benefit of chemotherapy in advanced stages and trials are ongoing to define its role in early stages as well.
Bhise, R, Guru Prasad B, B, Kundargi, R, Lakshmaia, KC, Purohit, S, Shetty, R   +5 more
core   +1 more source

Pericardial and pleural effusions associated with sirolimus and discussion of possible mechanisms [PDF]

, 2012
Sirolimus, a mammalian target of rapamycin inhibitor, is an increasingly used immunosuppressant in solid-organ transplantation. There are an increasing number of reports of unusual oedematous adverse effects associated with this drug, including ...
Almeida, M., Cabrita, A., Castro-Henriques, A., Dias, L., Martins, L., Pedroso, S., Rocha, S.   +6 more
core  

Rapamycin prevents cerebral stroke by modulating apoptosis and autophagy in penumbra in rats [PDF]

, 2018
Bové, Calastretti, Carloni, Castedo, Castedo, Chauhan, Chen, Chong, Chong, Donnan, Ferri, Flynn, Fu, Genova, Harada, Hwang, Hwang, Jiang, Kofman, Koh, Li, Li, Lu, Lu, Maiese, Rieker, Sanghera, Santini, Schmued, Shahjouei, Siddiqui, Thyrell, Urbanek, Wang, Wang, Wechsler, Wong, Xie, Xie, Yang, Yin, Zare, Zeng   +42 more
core   +2 more sources