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Targeting mammalian target of rapamycin (mTOR) for health and diseases
Drug Discovery Today, 2007The macrolide rapamycin is used clinically to treat graft rejection and restenosis. Mammalian target of rapamycin (mTOR) is a central controller of cellular and organism growth that integrates nutrient and hormonal signals, and regulates diverse cellular processes.
Chi Kwan, Tsang +3 more
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Mammalian Target of Rapamycin (mTOR)
2005The mammalian target of rapamycin (mTOR) is a giant serine/threonine protein kinase that plays a crucial role in a nutrient-sensitive signaling pathway that regulates cell growth and proliferation. The activity of mTOR is controlled by amino acids (especially by leucine, one of the branched-chain amino acids), in addition to growth factors and overall ...
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Mammalian target of rapamycin as a target in hematological malignancies
Targeted Oncology, 2011The mammalian target of rapamycin (mTOR) regulates protein synthesis in addition to cell growth and cell proliferation. Elucidation of the roles of the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR pathway in the regulation of the pathogenesis of hematological neoplasms has led to the development and clinical evaluation of agents targeting this pathway
Kevin R, Kelly +4 more
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Mammalian target of rapamycin as a therapeutic target in osteoporosis
Journal of Cellular Physiology, 2017The mechanistic target of rapamycin (mTOR) plays a key role in sensing and integrating large amounts of environmental cues to regulate organismal growth, homeostasis, and many major cellular processes. Recently, mounting evidences highlight its roles in regulating bone homeostasis, which sheds light on the pathogenesis of osteoporosis.
Gengyang Shen +11 more
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Mammalian target of rapamycin as a therapeutic target in oncology
Expert Opinion on Therapeutic Targets, 2008The mammalian target of rapamycin (mTOR) has emerged as a validated therapeutic target in cancer and mTOR inhibitors alter tumor cell responses to mitogenic signals and microenvironmental stress.The aims of this review are to describe the mTOR signaling pathway and the rationale for the use of rapamycin analogs and other mTOR inhibitors for oncology ...
Robert T, Abraham, Christina H, Eng
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Mammalian Target of Rapamycin as a Therapeutic Target in Leukemia
Current Molecular Medicine, 2005Reflecting its critical role in integrating cell growth and division with the cellular nutritional environment, the mammalian target of rapamycin *(mTOR) is a highly conserved downstream effector of the phosphatidylinositol 3-kinase (PI3K)/Akt (protein kinase B) signaling pathway. mTOR activates both the 40S ribosomal protein S6 kinase (p70s6k) and the
Francis J, Giles, Maher, Albitar
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Mammalian target of rapamycin: A new target in prostate cancer
Urologic Oncology: Seminars and Original Investigations, 2010Molecular targets in prostate cancer are continually being explored, especially in the poor-prognosis androgen-independent phase of the disease, for which there are currently few therapeutic options. One such target is the mammalian target of rapamycin (mTOR) protein.
Jaskarn S, Rai +2 more
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Mammalian target of rapamycin and tuberous sclerosis complex
Journal of Dermatological Science, 2015Mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that is a member of the phosphoinositide 3-kinase (PI3K)-related kinase (PIKK) family. mTOR forms two distinct complexes, mTORC1 and mTORC2. mTORC1 has emerged as a central regulator of cellular metabolism, cell proliferation, cellular differentiation, autophagy
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[mTOR, the mammalian target of rapamycin].
Medecine sciences : M/S, 2011The discovery of rapamycin from a soil sample on Easter Island in the mid 60's marked the beginning of an exciting field of research in cell biology and medicine. While it was first used as an antifungal and as an immunosuppressive drug, more recent studies confirmed rapamycin's antiproliferative properties over a variety of solid tumors.
Louis-André, Julien, Philippe P, Roux
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