Results 191 to 200 of about 174,708,283 (296)

Emerging insights into amino acid metabolism in the heart: implications for cardiovascular diseases and therapeutic targeting

British Journal of Pharmacology, EarlyView.
As a metabolically versatile organ, the heart is capable of generating energy from a wide range of substrates. Although fatty acid and glucose metabolism in the heart have been extensively studied, the contribution of amino acid metabolism to cardiac physiology and disease is gaining increasing attention.
Tayyiba Azam, Hongyuan Zhang, Min Zi, Chen Chen, Junfang Wu, Andreas Papapetropoulos, Xin Wang   +6 more
wiley   +1 more source

Inhibition of nuclear receptor coactivator 5 overcomes acquired lenvatinib resistance driven by protein kinase B-mammalian target of rapamycin signaling in hepatocellular carcinoma. [PDF]

Anticancer Drugs
Zhou H, Zhang Q, Yang L, Pan Z, Zheng H, Zhang Z, Li D, Li G, Liu X, Bao X, Liu C, Zhang W.   +11 more
europepmc   +1 more source

An inhibitor of the mitochondrial respiratory chain exerts synergistic anti‐tumour effects when combined with alkylating agents

British Journal of Pharmacology, EarlyView.
Background and Purpose Cancer cells exhibit the Warburg effect, but oxidative phosphorylation (OXPHOS) is also important for cancer cell proliferation. Metabolic reprogramming from glycolysis to OXPHOS is one mechanism of resistance to anti‐tumour drugs.
Emiri Omori Takaki, Yuya Hidoh, Yutaka Obuchi, Yoko Nagai, Shingo Nishikori, Yuki Kuniyoshi, Yasuhiro Sawai, Naoto Ohi   +7 more
wiley   +1 more source

Correction: Inhibition of cc chemokine receptor 10 ameliorates osteoarthritis via inhibition of the phosphoinositide-3-kinase/Akt/mammalian target of rapamycin pathway. [PDF]

J Orthop Surg Res
Luo Y, Zhou F, Wang X, Yang R, Li Y, Wu X, Ye B.   +6 more
europepmc   +1 more source

A20 Inhibits IFN‐γ Signaling in Hepatocellular Carcinoma Cells by Binding to STAT1, Compromising Anti‐Tumor Immunity

Cancer Science, EarlyView.
A20 suppresses IFN‐γ signaling in HCC cells by binding to STAT1 through its ZnF7 domain, thereby reducing CXCL9, CXCL10, and HLA‐ABC expression, ultimately impairing CD8+ T‐cell‐mediated anti‐tumor immunity. ABSTRACT Immune checkpoint blockade (ICB) has demonstrated efficacy in clinical cancer therapy; however, a significant proportion of cancer ...
Yanlei Dong, Jing Yi, Ruoxuan Yang, Yingyue Wang, Zelong Ma, Hong Yuan, Meichen Song, Ying Xiao, Chun Guo, Jianing Wang, Xiaoyan Wang, Faliang Zhu, Lining Zhang, Yuchen Fan, Yongyu Shi   +14 more
wiley   +1 more source

Effects of Huoxue Chubi decoction on protein kinase B-mammalian target of rapamycin autophagy pathway in scleroderma Balb/c model mice. [PDF]

J Tradit Chin Med
Xi C, Tiange QU, Hui J, Xingwu D, Jianhong LI, Kaihui Z, Runtian Z, Ruijie W.   +7 more
europepmc   +1 more source

The Serotonergic and Cholinergic Signaling Pathways Drive Gastric Precancerous Lesions and Its Potential Mechanism

Cancer Science, EarlyView.
Vagal cholinergic neurons promote gastric 5‐HT secretion, which drives gastric precancerous lesions through 5‐HTR1D and TRPV4, highlighting these as candidate targets for early intervention. ABSTRACT Gastric cancer (GC) is a leading lethal malignancy globally. Gastric precancerous lesion (GPL) represents a critical step in GC, but its neural regulatory
Shengli Gao, Xufei Feng, Nana Zhang, Jia Su, Yuyan Wang, Linghan Kong, Jianing Zhou, Hui Dong, Feifei Guo   +8 more
wiley   +1 more source

Does Lymphovenous Anastomosis Effect Mammalian Target of Rapamycin Inhibitor-associated Lymphedema Patients? [PDF]

Arch Plast Surg
Yoon I, Kim HB, Cho J, Pak CJ, Suh HP, Jeon JY, Hong JP.   +6 more
europepmc   +1 more source

Sirolimus is effective for paediatric Evans syndrome and secondary autoimmune cytopenias: A retrospective cohort study

British Journal of Haematology, EarlyView.
Maggie McNeill, Camilla Cellarius, Nethmi Illamperuma, Rachelle Zipper, Clarisse Carcao, Jillian M. Baker, Sheila Butchart, Michelle Fantauzzi, Caroline Malcolmson, Reena Pabari, Diandra Rollan, Kathleen Qu, Manuel Carcao   +12 more
wiley   +1 more source

Out of the Ordinary, but Not Out of the Question: Atypia in Pancreatic Lesions Is Not Always Carcinoma

Cytopathology, EarlyView.
An incidental pancreatic lesion in a 69‐year‐old woman was sampled by EUS‐guided fine‐needle biopsy. Integrated cytopathological and histopathological evaluation with immunochemical staining supported organ‐preserving surgery. ABSTRACT Pancreatic perivascular epithelioid cell tumours (PEComas) are exceptionally rare mesenchymal neoplasms.
Maja Kebe Radulovic, Branislava Rankovic, Ajda Toni, Margareta Zlajpah, Darko Siuka   +4 more
wiley   +1 more source