Results 211 to 220 of about 174,708,283 (296)

Topical calcineurin and mammalian target of rapamycin inhibitors in inflammatory dermatoses: Current challenges and nanotechnology‑based prospects (Review). [PDF]

Int J Mol Med
Sidiropoulou P, Katsarou M, Sifaki M, Papasavva M, Drakoulis N.   +4 more
europepmc   +1 more source

Selective autophagy pathways in ageing and neurodegeneration: Emerging roles for mitophagy and nucleophagy

The FEBS Journal, EarlyView.
As we age, cells gradually accumulate damage, which can contribute to disease and neurodegeneration. This review explores how two cellular recycling processes, mitophagy and nucleophagy, remove damaged mitochondria and nuclear material, respectively, to maintain cell health and long‐term neuronal homeostasis.
Maria Markaki, Nektarios Tavernarakis
wiley   +1 more source

Regulation of Metabolic Aging Through Adenosine Mono Phosphate-Activated Protein Kinase and Mammalian Target of Rapamycin: A Comparative Study of Intermittent Fasting Variations in Obese Young Women. [PDF]

Nutrients
Purnomo SP, Rejeki PS, Argarini R, Halim S, Rachmayanti DA, Permataputri CDA, Singgih IK.   +6 more
europepmc   +1 more source

Wound complications frequency in heart transplant recipients on mammalian target of rapamycin inhibitors: A meta-analysis.

Int Wound J, 2023
Zhu S, Yu W, Gao J, Xiong J.
europepmc   +1 more source

Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines

Immunology, EarlyView.
This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw, Aytenew Atnaf, Bantayehu Addis Tegegne, Abebe Fenta, Bantegzie Selabat, Temesgen Baylie, Yonatan Kindie, Zigale Hibstu Teffera, Mekuriaw Belayneh, Mohammed Jemal, Adane Adugna   +10 more
wiley   +1 more source

Proteostasis in the regulation of pancreatic islet cell plasticity

Journal of Diabetes Investigation, EarlyView.
Adaptive proteostasis integrates protein synthesis, folding, trafficking, and degradation through ISR, UPR, ER stress responses, autophagy, and proteasomal degradation. In pancreatic islet cells, this coordinated network preserves protein quality, secretory function, proliferation, and survival, enabling adaptation to metabolic stress and aging while ...
Jun Shirakawa
wiley   +1 more source

Rapamycin ameliorates inflammatory pain via recovery of autophagy flux mediated by mammalian target of rapamycin (mTOR) signaling pathway in the rat spinal cord. [PDF]

Int J Immunopathol Pharmacol
Zhang J, Chen S, Zhang R, Zheng X, Liu C, Zhang J, Zhang L, Yang Z, Wang L.   +8 more
europepmc   +1 more source

Renal glycogen handling in diabetes: A narrative review of diabetic kidney disease pathogenesis

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Kidney disease is a major microvascular complication of diabetes, affecting approximately 40% of individuals with diabetes, and is a leading cause of end‐stage renal disease. Besides the functional consequences of hyperglycemia; hemodynamic alterations are well understood.
Deenadhayalan Ashok, Poornima Ajay Manjrekar, Bhushan Chandrahasa Shetty, Sujina Simon Sailet   +3 more
wiley   +1 more source

Potential of Vitamin D and l-Cysteine Co-supplementation to Downregulate Mammalian Target of Rapamycin: A Novel Therapeutic Approach to Diabetes. [PDF]

Metab Syndr Relat Disord
Stevens CM, Weeks K, Jain SK.
europepmc   +1 more source

Body Composition, Physical Activity and Energy Requirements Estimated Using Two Isotopic Methods in Old and Adult Beagle Dogs

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Energy requirements (ER) are known to decline as dogs age into the senior stage. However, the implications of body composition and physical activity (PA) on this parameter remain poorly investigated. The aim of this study was to evaluate ER, body composition, water turnover rate (WTR), and voluntary PA by triaxial accelerometers in adults (5.2 
Ariel de Castro, Letícia Graziele Pacheco, Camila Goloni, Vladimir Eliodoro Costa, Aulus Cavalieri Carciofi   +4 more
wiley   +1 more source