Results 171 to 180 of about 174,708,283 (296)

Irisin Potentiates 5-fluorouracil Cytotoxicity in HT-29 Colon Cancer Cells through Enhanced Apoptosis and Transcriptional Modulation of Adenosine Monophosphate-activated Protein Kinase/Mammalian Target of Rapamycin Signaling. [PDF]

Int J Appl Basic Med Res
Refaat B.
europepmc   +1 more source

A New Hypothesis Describing the Pathogenesis of Oral Mucosal Injury Associated with the Mammalian Target of Rapamycin (mTOR) Inhibitors. [PDF]

Cancers (Basel), 2023
Sonis ST, Villa A.
europepmc   +1 more source

TcALS knockdown accelerates metamorphosis via insulin signaling in Tribolium castaneum

Insect Science, EarlyView.
RNAi silencing of TcALS accelerates larva‐to‐pupa metamorphosis in Tribolium castaneum. Abstract Insect metamorphosis is an evolutionary adaptation precisely regulated by nutritional and hormonal cues. The red flour beetle Tribolium castaneum, a major stored‐product pest, serves as an excellent model for studying this process.
Min Li, Jie Chen, Zi‐Ye Wang, Fei‐Feng Wang, Lu‐Lu Dong, Jun Pan, Min‐Er Li, Lin Yu, Wen Sang   +8 more
wiley   +1 more source

Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease. [PDF]

Signal Transduct Target Ther, 2023
Panwar V, Singh A, Bhatt M, Tonk RK, Azizov S, Raza AS, Sengupta S, Kumar D, Garg M.   +8 more
europepmc   +1 more source

Impact of Metformin and Diabetes on Tumor Response to Total Neoadjuvant Therapy in Advanced Rectal Cancer: A Multicenter Retrospective Cohort Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In advanced rectal cancer patients receiving total neoadjuvant therapy (TNT), overall tumor response did not differ by diabetes status or metformin use. However, among diabetic patients, metformin use was associated with higher overall complete response rates. These findings suggest a potential benefit of metformin in enhancing TNT response in diabetic
Sergei Bedrikovetski, Mahima Raju, Tracy Fitzsimmons, Ishraq Murshed, Timothy J. Price, Michael Penniment, Sudarsha Selva‐Nayagam, Tarik Sammour   +7 more
wiley   +1 more source

Activation of the Mammalian Target of Rapamycin Pathway in Endothelial Cells in Antiphospholipid Antibody-Positive Patients with Leg Ulcers. [PDF]

Int J Mol Sci
Kovács AL, Gyömörei C, Horváth S, Németh V, Dudley R, Nagy Z, Berki T, Lengyel Z, Gyulai R.   +8 more
europepmc   +1 more source

Serotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions

Allergy, EarlyView.
Human Tc2 cells exhibit a metabolically active phenotype characterized by enhanced glycolysis, mitochondrial respiration, and fatty acid uptake dependent on PPARγ. Alarmins strongly amplify IL‐5 and IL‐13 production in Tc2 cells, supporting a shared immunometabolic program across type 2 lymphocytes.
Sabrina de Souza Ferreira, Lisa Holla, Sophia Björkander, Marie Kaarup Bek, Lorenz Wirth, Patrick A. Shearer, Jesper Säfholm, Erik Sachs, Mamdoh Al‐Ameri, Kasra Vali, Sandra Ekström, Erik Melén, Jenny Mjösberg, Christopher Andrew Tibbitt   +13 more
wiley   +1 more source

<i>RPF2</i> regulates the protein kinase B/mammalian target of rapamycin pathway in the pathogenesis of <i>Helicobacter pylori</i>. [PDF]

World J Gastrointest Oncol
Hua YQ, Guo KX, Ni P, Wang D, An TY, Gao YY, Zhang RG.   +6 more
europepmc   +1 more source

Mammalian target of rapamycin inhibition impacts energy homeostasis and induces sex-specific body weight loss in humans. [PDF]

J Cachexia Sarcopenia Muscle, 2023
Mannaa M, Pfennigwerth P, Fielitz J, Gollasch M, Boschmann M.   +4 more
europepmc   +1 more source

Ubiquitin C-terminal hydrolase L5 promotes the development of renal cell carcinoma through the glycolysis mediated by the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway. [PDF]

Cytojournal
Ruan L, Li S, Xu L.
europepmc   +1 more source