Sphingosine-1-phosphate–induced smooth muscle cell migration involves the mammalian target of rapamycin [PDF]
, 2005 BackgroundVascular smooth muscle cell (SMC) migration is an important component of the development of intimal hyperplasia. Sphingosine-1-phosphate (S-1-P) is a lipid released from activated platelets with numerous cellular effects including the ...
Tanski, William J. +5 more
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Phase I study of everolimus and mitomycin C for patients with metastatic esophagogastric adenocarcinoma [PDF]
, 2013 This study aimed at determining the recommended dose of the mammalian target of rapamycin inhibitor everolimus in combination with mitomycin C (MMC) in patients with previously treated metastatic esophagogastric cancer.
Atmaca, Akin +5 more
core +1 more source
Advanced Research of mTOR and Lung Carcinoid Tumors
Chinese Journal of Lung Cancer, 2013 Mammalian target of rapamycin (mTOR), a main protein kinase in the phosphoinositide 3-kinase (PI3K)/AKT/mTOR signaling pathway, is an important intracellular mediator involved in multiple celluar functions including proliferation, differentiation ...
Zixuan ZHANG, Mengzhao WANG
doaj +1 more source
Activated mammalian target of rapamycin is a potential therapeutic target in gastric cancer
BMC Cancer, 2010 Background The mammalian target of rapamycin (mTOR) plays a key role in cellular growth and homeostasis. The purpose of our present study is to investigate the expression of activated mTOR (p-mTOR) in gastric cancer patients, their prognostic ...
Zhan You-qing +12 more
doaj +1 more source
First-in-Human Phase I Study to Evaluate the Brain-Penetrant PI3K/mTOR Inhibitor GDC-0084 in Patients with Progressive or Recurrent High-Grade Glioma. [PDF]
, 2020 PurposeGDC-0084 is an oral, brain-penetrant small-molecule inhibitor of PI3K and mTOR. A first-in-human, phase I study was conducted in patients with recurrent high-grade glioma.Patients and methodsGDC-0084 was administered orally, once daily, to ...
Cloughesy, Timothy F +11 more
core
Metabolic regulation of regulatory T cell development and function [PDF]
, 2014 It is now well established that the effector T cell (Teff) response is regulated by a series of metabolic switches. Quiescent T cells predominantly require ATP-generating processes, whereas proliferating Teff require high metabolic flux through growth ...
Alves +68 more
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Mammalian Target of Rapamycin [PDF]
The American Journal of Pathology, 2019 Matthew F. Wipperman +3 more
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Antineoplastic effects of mammalian target of rapamycine inhibitors
World Journal of Transplantation, 2012 Cancer after transplantation is the third cause of death and one of the more relevant comorbidities. Aim of this review is to verify the role of different pathogenetic mechanisms in cancer development in transplant patients and in general population as well. In particular has been outlined the different role exerted by two different families of drug as
openaire +2 more sources
Transplantation Reports, 2018 Chronic rejection of transplanted organs remains an unresolved issue in clinical organ transplantation. The macrophages play a crucial role in the development of chronic rejection.
Wei Chen +4 more
doaj +1 more source
Advanced gynecologic malignancies treated with a combination of the VEGF inhibitor bevacizumab and the mTOR inhibitor temsirolimus. [PDF]
, 2014 BackgroundBevacizumab and temsirolimus are active agents in gynecologic tumors. Temsirolimus attenuates upregulation of HIF-1α levels, a resistance mechanism for antiangiogenics, and targets the PI3-kinase/AKT/mTOR axis, commonly aberrant in these tumors.
Falchook, Gerald S +9 more
core +3 more sources