Results 61 to 70 of about 770,892 (320)

Daily torpor and hibernation in birds and mammals

Biological Reviews of The Cambridge Philosophical Society, 2015
Many birds and mammals drastically reduce their energy expenditure during times of cold exposure, food shortage, or drought, by temporarily abandoning euthermia, i.e. the maintenance of high body temperatures.
T. Ruf, F. Geiser
semanticscholar   +1 more source

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

Detection of Herpesviruses in Wild Bird Casualties in Slovenia

Frontiers in Veterinary Science, 2022
The complete host range of avian herpesviruses in wild birds is unknown, and information about nucleotide sequences is available only in limited cases.
Zoran Žlabravec, Brigita Slavec, Al Vrezec, Al Vrezec, Urška Kuhar, Olga Zorman Rojs, Zlatko Golob, Jožko Račnik   +7 more
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Observation of Mammalian Similarity Through Allometric Scaling Laws [PDF]

, 2002
We discuss the problem of observation of natural similarity in skeletal evolution of terrestrial mammals. Analysis is given by means of testing of the power scaling laws established in long bone allometry, which describe development of bones (of length $L$ and diameter $D$) with body mass in terms of the growth exponents, \QTR{it}{e.g.} $\lambda =d\log
arxiv   +1 more source

The functional roles of mammals in ecosystems

Journal of Mammalogy, 2019
The diverse functional roles of over 6,000 species of extant mammals that range in body size across eight orders of magnitude, from blue whales (Balaenoptera musculus) to tiny Etruscan shrews (Suncus etruscus), contribute to shaping Earth's ecosystems ...
T. Lacher, Ana D. Davidson, T. Fleming, Emma P. Gómez-Ruiz, G. McCracken, N. Owen‐Smith, C. Peres, S. B. Wall   +7 more
semanticscholar   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Development and Application of the Owner-Bird Relationship Scale (OBRS) to Assess the Relation of Humans to Their Pet Birds

Frontiers in Veterinary Science, 2020
Only a few birds besides domestic pigeons and poultry can be described as domesticated. Therefore, keeping a pet bird can be challenging, and the human-avian relationship will have a major influence on the quality of this cohabitation. Studies that focus
Anne-Kathrin Burmeister, Katrin Drasch, Monika Rinder, Sebastian Prechsl, Andrea Peschel, Rüdiger Korbel, Nicole J. Saam   +6 more
doaj   +1 more source

Dynamics of genome size evolution in birds and mammals

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance Deciphering the forces and mechanisms modulating genome size is central to our understanding of molecular evolution, but the subject has been understudied in mammals and birds. We took advantage of the recent availability of genome sequences
A. Kapusta, Alexander Suh, C. Feschotte
semanticscholar   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source