Results 11 to 20 of about 733,542 (207)

Stem Cells and the Differentiation Hierarchy in Mammary Gland Development.

Physiological Reviews, 2020
The mammary gland is a highly dynamic organ that undergoes profound changes within its epithelium during puberty and the reproductive cycle. These changes are fuelled by dedicated stem and progenitor cells.
Nai-yang Fu, E. Nolan, G. Lindeman, J. Visvader   +3 more
semanticscholar   +1 more source

The molecular basis of mammary gland development and epithelial differentiation.

Seminars in Cell and Developmental Biology, 2020
Our understanding of the molecular events underpinning the development of mammalian organ systems has been increasing rapidly in recent years. With the advent of new and improved next-generation sequencing methods, we are now able to dig deeper than ever
Priscila F. Slepicka, Amritha Varshini Hanasoge Somasundara, C. D. Dos Santos   +2 more
semanticscholar   +1 more source

The Diagnostic Value of Bedside Echocardiography and Lower Extremity Blood Vessels in Acute Pulmonary Embolism

Stem Cells International, 2022
Objective. The study aimed to evaluate the value of bedside echocardiography (TTE) and lower extremity blood vessels in diagnosis and prognosis of acute pulmonary embolism (APE). Methods.
Xinxin Xu, Jing Yuan, Xiaojie Pan, Guibin Du, Jiahui Zhang   +4 more
doaj   +1 more source

A review of current progress in triple-negative breast cancer therapy

Open Medicine, 2020
Triple-negative breast cancer (TNBC) is a particularly aggressive subtype known for its extremely high drug resistance, progression, poor prognosis, and lack of clear therapeutic targets. Researchers are aiming to advance TNBC treatment worldwide. In the
Shen Meiying, Pan Huawen, Chen Yuxia, Xu Yu Hang, Yang Weixiong, Wu Zhaojun   +5 more
doaj   +1 more source

Single-Cell Transcriptomics Identifies Heterogeneity of Mouse Mammary Gland Fibroblasts With Distinct Functions, Estrogen Responses, Differentiation Processes, and Crosstalks With Epithelium

Frontiers in Cell and Developmental Biology, 2022
Fibroblasts have been shown to be one of the essential players for mammary gland organization. Here, we identify two major types of mouse mammary gland fibroblasts through single-cell RNA sequencing analysis: Dpp4+ fibroblasts and Dpp4- fibroblasts. Each
Ryohei Yoshitake, Gregory Chang, Kohei Saeki, Kohei Saeki, Desiree Ha, Xiwei Wu, Jinhui Wang, Shiuan Chen   +7 more
doaj   +1 more source

Expression analysis of rare cellular subsets: direct RT-PCR on limited cell numbers obtained by FACS or soft agar assays

BioTechniques, 2013
Since tissues and tumors are heterogenous populations containing different cell types, their transcriptomes are blends of multiple mRNA expression profiles.
Victor Ho, Shi Yun Yeo, Kamini Kunasegaran, Duvini De Silva, Gerard A. Tarulli, P. Mathijs Voorhoeve, Alexandra M. Pietersen   +6 more
doaj   +1 more source

A Robust Mammary Organoid System to Model Lactation and Involution-like Processes

Bio-Protocol, 2021
The mammary gland is a highly dynamic tissue that changes throughout reproductive life, including growth during puberty and repetitive cycles of pregnancy and involution. Mammary gland tumors represent the most common cancer diagnosed in women worldwide.
Elsa Charifou, Jakub Sumbal, Zuzana Koledova, Han Li, Aurelie Chiche   +4 more
doaj   +1 more source

Investigating the effect of positional variation on mid-lactation mammary gland transcriptomics in mice fed either a low-fat or high-fat diet.

PLoS ONE, 2021
Little attention has been given to the effect of positional variation of gene expression in the mammary gland. However, more research is shedding light regarding the physiological differences that mammary gland location can have on the murine mammary ...
Adrienne A Cheng, Wenli Li, Laura L Hernandez   +2 more
doaj   +1 more source

Progesterone promotes immunomodulation and tumor development in the murine mammary gland

Journal for ImmunoTherapy of Cancer, 2021
Background Clinical studies have linked usage of progestins (synthetic progesterone [P4]) to breast cancer risk. However, little is understood regarding the role of native P4, signaling through the progesterone receptor (PR), in breast tumor formation ...
Alfredo A Molinolo, Junping Wei, Xiao-Yi Yang, Gangjun Lei, Zachary C Hartman, Lauryn R Werner, Katelin A Gibson, Merit L Goodman, Dominika E Helm, Katherine R Walter, Sean M Holloran, Gloria M Trinca, Richard C Hastings, Howard H Yang, Rashna Madan, Mary A Markiewicz, Prabhakar Chalise, Margaret L Axelrod, Justin M Balko, Kent W Hunter, Carol A Lange, Christy R Hagan   +21 more
doaj   +1 more source

Anti-Collagenase, Anti-Hyaluronidase, Anti-Elastase, and Anti Breast Cancer Potential of Hirsutenone as Natural Compound: In vitro Study, Molecular Docking and Dynamics Simulation Studies [PDF]

Iranian Journal of Chemistry & Chemical Engineering
Many natural medicines derived from Chinese herbs have been discovered recently to have anti-cancer potential both in vitro and in silico. In this work, Hyaluronidase molecule inhibited the enzymes collagenase, elastase, and hyaluronidase.
Zhibing Zhou, Bing Zhou, Yue Gao, Xiaobo Wu, Wensong Wei, Erwei Hu, Shiqing Li   +6 more
doaj   +1 more source