Results 11 to 20 of about 142,576 (312)

The Mammary Gland Vasculature Revisited [PDF]

Journal of Mammary Gland Biology and Neoplasia, 2010
Concomitant with the extensive growth and differentiation of the mammary epithelium during pregnancy and lactation, and epithelial involution after weaning, the vasculature of the mammary gland undergoes repeated cycles of expansion and regression.
Anne-Catherine, Andres, Valentin, Djonov
openaire   +3 more sources

A review of current progress in triple-negative breast cancer therapy

Open Medicine, 2020
Triple-negative breast cancer (TNBC) is a particularly aggressive subtype known for its extremely high drug resistance, progression, poor prognosis, and lack of clear therapeutic targets. Researchers are aiming to advance TNBC treatment worldwide. In the
Shen Meiying, Pan Huawen, Chen Yuxia, Xu Yu Hang, Yang Weixiong, Wu Zhaojun   +5 more
doaj   +1 more source

Single-Cell Transcriptomics Identifies Heterogeneity of Mouse Mammary Gland Fibroblasts With Distinct Functions, Estrogen Responses, Differentiation Processes, and Crosstalks With Epithelium

Frontiers in Cell and Developmental Biology, 2022
Fibroblasts have been shown to be one of the essential players for mammary gland organization. Here, we identify two major types of mouse mammary gland fibroblasts through single-cell RNA sequencing analysis: Dpp4+ fibroblasts and Dpp4- fibroblasts. Each
Ryohei Yoshitake, Gregory Chang, Kohei Saeki, Kohei Saeki, Desiree Ha, Xiwei Wu, Jinhui Wang, Shiuan Chen   +7 more
doaj   +1 more source

Development of the mammary gland [PDF]

Reproduction, 1982
Introduction The first obvious statement is that the mammary gland is an intriguing structure, and that its development is one of the most fascinating aspects. During the lifetime of the animal the mammary gland probably undergoes more and greater changes in size, structure, composition and activity than any ...
C H, Knight, M, Peaker
openaire   +2 more sources

Expression analysis of rare cellular subsets: direct RT-PCR on limited cell numbers obtained by FACS or soft agar assays

BioTechniques, 2013
Since tissues and tumors are heterogenous populations containing different cell types, their transcriptomes are blends of multiple mRNA expression profiles.
Victor Ho, Shi Yun Yeo, Kamini Kunasegaran, Duvini De Silva, Gerard A. Tarulli, P. Mathijs Voorhoeve, Alexandra M. Pietersen   +6 more
doaj   +1 more source

A Robust Mammary Organoid System to Model Lactation and Involution-like Processes

Bio-Protocol, 2021
The mammary gland is a highly dynamic tissue that changes throughout reproductive life, including growth during puberty and repetitive cycles of pregnancy and involution. Mammary gland tumors represent the most common cancer diagnosed in women worldwide.
Elsa Charifou, Jakub Sumbal, Zuzana Koledova, Han Li, Aurelie Chiche   +4 more
doaj   +1 more source

ß1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli [PDF]

, 2005
Integrins are cell adhesion receptors which mediate interactions between the extracellular matrix and the actin cytoskeleton. They are heterodimers composed of α and β subunits. As adhesion receptors, integrins are important for cell-cell and cell-matrix
Li, Na
core   +1 more source

Investigating the effect of positional variation on mid-lactation mammary gland transcriptomics in mice fed either a low-fat or high-fat diet.

PLoS ONE, 2021
Little attention has been given to the effect of positional variation of gene expression in the mammary gland. However, more research is shedding light regarding the physiological differences that mammary gland location can have on the murine mammary ...
Adrienne A Cheng, Wenli Li, Laura L Hernandez   +2 more
doaj   +1 more source

Progesterone promotes immunomodulation and tumor development in the murine mammary gland

Journal for ImmunoTherapy of Cancer, 2021
Background Clinical studies have linked usage of progestins (synthetic progesterone [P4]) to breast cancer risk. However, little is understood regarding the role of native P4, signaling through the progesterone receptor (PR), in breast tumor formation ...
Alfredo A Molinolo, Junping Wei, Xiao-Yi Yang, Gangjun Lei, Zachary C Hartman, Lauryn R Werner, Katelin A Gibson, Merit L Goodman, Dominika E Helm, Katherine R Walter, Sean M Holloran, Gloria M Trinca, Richard C Hastings, Howard H Yang, Rashna Madan, Mary A Markiewicz, Prabhakar Chalise, Margaret L Axelrod, Justin M Balko, Kent W Hunter, Carol A Lange, Christy R Hagan   +21 more
doaj   +1 more source

Insulin-like growth factor binding proteins initiate cell death and extracellular matrix remodeling in the mammary gland [PDF]

, 2005
We have demonstrated that insulin-like growth factor binding protein-5 (IGFBP-5) production by mammary epithelial cells increases dramatically during forced involution of the mammary gland in rats, mice and pigs.
Beattie, J, Whitelaw C. B. A., ACCORSI, PIER ATTILIO, Hurley, W, Boutinaud, M, Kolb A., Allan G. A., Tonner, E, Wilde, C J, Boutinaud M., Wilde C. J., Beattie J., Accorsi, P A, Flint, D J, Flint D. J., Tonner E., Whitelaw, C B A, Hurley W., Kolb, A F, Allan, G J   +19 more
core   +1 more source