Results 21 to 30 of about 733,542 (207)

Long noncoding RNA LINC00511 contributes to breast cancer tumourigenesis and stemness by inducing the miR-185-3p/E2F1/Nanog axis

open access: yesJournal of Experimental & Clinical Cancer Research, 2018
Background Emerging evidence have illustrated the vital role of long noncoding RNAs (lncRNAs) long intergenic non-protein coding RNA 00511 (LINC00511) on the human cancer progression and tumorigenesis.
Guanming Lu   +11 more
doaj   +1 more source

LncRNA SNHG6 enhances the radioresistance and promotes the growth of cervical cancer cells by sponging miR-485-3p

open access: yesCancer Cell International, 2020
Background Cervical cancer (CC) is the one of most common malignant gynecological tumors, which is characterized with the high mortality and recurrence rate.
Jin Liu, Xiaojiao Liu, Rong Li
doaj   +1 more source

MiR-382 inhibits proliferation and migration of triple negative breast cancer cell line 4T1 by mediating PGC-1α

open access: yesDi-san junyi daxue xuebao, 2019
Objective To explore the effect of miR-382 down-regulating PGC-1α on the biological behaviors of triple negative breast cancer 4T1 cells. Methods ① After miR-382 mimics or inhibitory probe anti-miR-382 was transfected into 4T1 cells, the expression level
LEI Youyang   +4 more
doaj   +1 more source

Pleiotrophin (PTN) expression and function and in the mouse mammary gland and mammary epithelial cells. [PDF]

open access: yesPLoS ONE, 2012
Expression of the heparin-binding growth factor, pleiotrophin (PTN) in the mammary gland has been reported but its function during mammary gland development is not known. We examined the expression of PTN and its receptor ALK (Anaplastic Lymphoma Kinase)
Sonia M Rosenfield   +7 more
doaj   +1 more source

Early lineage segregation of multipotent embryonic mammary gland progenitors

open access: yesNature Cell Biology, 2018
The mammary gland is composed of basal cells and luminal cells. It is generally believed that the mammary gland arises from embryonic multipotent progenitors, but it remains unclear when lineage restriction occurs and what mechanisms are responsible for ...
Aline Wuidart   +11 more
semanticscholar   +1 more source

Downregulation of CXXC Finger Protein 4 Leads to a Tamoxifen-resistant Phenotype in Breast Cancer Cells Through Activation of the Wnt/β-catenin Pathway

open access: yesTranslational Oncology, 2020
Tamoxifen is a successful endocrine therapy drug for estrogen receptor–positive (ER+) breast cancer. However, resistance to tamoxifen compromises the efficacy of endocrine treatment.
Yijie Fu   +6 more
doaj   +1 more source

Symposium review: The influences of heat stress on bovine mammary gland function.

open access: yesJournal of Dairy Science, 2018
Heat stress reduces cow milk yield and results in a significant economic loss for the dairy industry. During lactation, heat stress lowers milk production by 25 to 40% with half of the decrease in milk synthesis resulting from the reduced feed intake. In
Sha Tao   +5 more
semanticscholar   +1 more source

Comparative Analysis of the miRNome of Bovine Milk Fat, Whey and Cells. [PDF]

open access: yesPLoS ONE, 2016
Abundant miRNAs have been identified in milk and mammary gland tissues of different species. Typically, RNA in milk can be extracted from different fractions including fat, whey and cells and the mRNA transcriptome of milk could serve as an indicator of ...
Ran Li   +4 more
doaj   +1 more source

Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling

open access: yesNature Communications, 2017
The mammary epithelium comprises two primary cellular lineages, but the degree of heterogeneity within these compartments and their lineage relationships during development remain an open question.
B. Pal   +13 more
semanticscholar   +1 more source

MiR-486 regulates lactation and targets the PTEN gene in cow mammary glands.

open access: yesPLoS ONE, 2015
Mammary gland development is controlled by several genes. Although miRNAs have been implicated in mammary gland function, the mechanism by which miR-486 regulates mammary gland development and lactation remains unclear. We investigated miR-486 expression
Dan Li   +6 more
doaj   +1 more source

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