Results 171 to 180 of about 42,336 (264)

Targeting Fatty Acid Synthase With Berberine Promotes IL‐10 Production in Macrophages and Prevents Relapse in a Murine Colitis Model

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Berberine enhances IL‐10 production in macrophages via FASN‐dependent mechanisms, thereby promoting epithelial repair and preventing colitis relapse. Created with BioRender.com. ABSTRACT Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by alternating periods of remission and relapse.
Shusaku Hayashi, Yudai Ogawa, Nonoka Wakabayashi, Koga Tokuyama, Makito Oku, Takeshi Yamamoto, Shinichi Kato, Asma Nusrat, Makoto Kadowaki   +8 more
wiley   +1 more source

LOX Inhibition Disrupts a Collagen-Integrin-MYC Axis to Suppress Progression of Invasive Lobular Carcinoma. [PDF]

Cancer Res
Flaherty RL, Hughes F, Sflomos G, Ronchi C, Kemp H, Roumeliotis TI, Nicholas AA, Ambrosini G, Ziehme A, Becker S, Yang WW, Zhang Y, Quinn HM, Battista L, Padda H, Pezot S, Jouny S, Liu Y, Brough R, Marlow R, Iravani M, Okines AFC, Turner NC, Stravodimou A, Zaman K, Fiche M, Howard BA, Choudhary JS, Sanz-Moreno V, Isacke CM, Perryman L, Jarolimek W, Haider S, Lord CJ, Brisken C.   +34 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, Volume 16, Issue 6, Page 1166-1180, June 2026.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Nanoluciferase-CD63 labeling reveals extracellular vesicle kinetics in a mouse intraductal model of ductal carcinoma in situ. [PDF]

Breast Cancer Res
Hladik C, Elayapillai SP, Dogra S, Bruns M, Wellberg EA, Filatenkov A, Behbod F, Hannafon BN.   +7 more
europepmc   +1 more source

Shaping Ti3C2 MXene Nanospheres for Precision Near‐Infrared Photothermal Therapy

Advanced Functional Materials, Volume 36, Issue 46, 8 June 2026.
In this study, we report producing spherical MXenes via fs laser fragmentation of Ti3C2 flakes in liquid medium. The nanoparticles demonstrated pronounced light absorption and high photothermal conversion efficiencies of 68% and 63% under heating with NIR‐I and NIR‐II lasers, respectively.
Julia S. Babkova, Ivan V. Zelepukin, Konstantin G. Shevchenko, Gleb V. Tikhonowski, Lyubov V. Gorelik, Anton A. Popov, Anna S. Sogomonyan, Alina Yu. Kapitannikova, Ivan S. Kazantsev, Dmitry V. Dyubo, Daria A. Panova, Daniil I. Tselikov, Anton A. Minnekhanov, Aziz B. Mirkasymov, Georgy A. Ermolaev, Alexander V. Syuy, Gleb I. Tselikov, Aleksey V. Arsenin, Andrei V. Kabashin, Kostya S. Novoselov, Sergey M. Deyev, Valentyn S. Volkov   +21 more
wiley   +1 more source

Effects of exposure to ethinyl estradiol during pregnancy and lactation on the postinvolution mammary gland. [PDF]

J Endocr Soc
Mogus JP, Maharaj-Chama P, Vandenberg LN.   +2 more
europepmc   +1 more source

Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System

Advanced Healthcare Materials, Volume 15, Issue 23, 19 June 2026.
ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett, Laura Bahlmann, Ryan Ogi, Angela Jiao, Priyatanu Roy, Matthew Johnson, David Trumper, Linda Griffith   +7 more
wiley   +1 more source

Protective Efficacy of a Hemagglutinin-Based mRNA Vaccine Against H5N1 Influenza Virus Challenge in Lactating Dairy Cows. [PDF]

Research (Wash D C)
Kong H, Yang J, Shi J, Cui P, Zeng X, Liu W, He X, Zhang X, Chen L, Zhuang Y, Wang Y, Ma J, Li J, Zhang Y, Wang C, He C, Li J, Yang J, Liu J, Chen P, Guan Y, Bu Z, Jiang Y, Chen H.   +23 more
europepmc   +1 more source

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, Volume 15, Issue 23, 19 June 2026.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, Volume 13, Issue 35, 24 June 2026.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source