Results 191 to 200 of about 42,336 (264)

Interleukin‐5, Eosinophils, and Interleukin‐5 Pathway Inhibitors in Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, Volume 78, Issue 6, Page 1196-1205, June 2026.
Interlukin‐5 (IL‐5) plays a crucial role in the pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) by promoting eosinophil differentiation, activation, and survival. We present here a typical case of EGPA in which treatment with IL‐5 pathway inhibitors is prescribed, showing to be beneficial for the patient.
Alvise Berti, Christian Pagnoux
wiley   +1 more source

Little women: the relevance and reliance on mouse models for mammary gland research and next steps for translation. [PDF]

J Mammary Gland Biol Neoplasia
Bjerre LB, Chalmers SB, Davis FM.
europepmc   +1 more source

Nonclinical Considerations for Support of Pregnancy and Lactation in Clinical Trials

Birth Defects Research, Volume 118, Issue 6, June 2026.
ABSTRACT Background Pregnant and breastfeeding individuals remain underrepresented in clinical drug development, leaving health care providers and patients with limited data to inform treatment decisions. Current practice relies heavily on nonclinical developmental and reproductive toxicity (DART) studies in animals, while clinical trials typically ...
Dinesh Stanislaus, Christopher J. Bowman, Kimberly C. Brannen, Sarah N. Campion, Laura M. Carlson, Stephan Chalon, Anthony M. DeLise, Claudia Demarta‐Gatsi, Brian P. Enright, Wendy Halpern, Shermaine Mitchell‐Ryan, Vicki Sutherland, Karen Thacker, Kary Thompson, Belen Tornesi, Steven Van Cruchten, Ronald L. Wange, Tacey White, Connie L. Chen   +18 more
wiley   +1 more source

Metastasis suppressing properties of the cell-surface anchored serine protease prostasin: new functional and mechanistic insights from breast cancer. [PDF]

Oncogenesis
Lundgren JG, Flynn MG, Winkler AR, Rivera BN, Tanabe LM, Stemmer PM, Chen LM, Chai KX, List K.   +8 more
europepmc   +1 more source

A working model for CCN3 C‐terminal domain‐mediated transcriptional modulation of the plasminogen activation system

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Plasminogen is a circulating zymogen that is converted into active plasmin by plasminogen activators such as tissue plasminogen activator (tPA) and urokinase‐type PA (uPA). This conversion is regulated by plasminogen activator inhibitors (PAI‐1, PAI‐2) and by inhibitors of plasmin itself, maintaining a fine balance between activation and inhibition of ...
Bernard Perbal
wiley   +1 more source

Developing Mammary Gland Models for Biomedical Applications. [PDF]

Research (Wash D C)
Zhao J, Lin X, Zhang H, Zhao Y.
europepmc   +1 more source

Clinical and Pathological Characteristics and Prognosis of Breast Cancer During Pregnancy and Postpartum: A Multicenter Retrospective Study

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Purpose The prognostic impact of the interval between the most recent childbirth and breast cancer diagnosis remains insufficiently defined, particularly when breast cancer diagnosed during pregnancy (PrBC) is distinguished from postpartum breast cancer (PPBC).
Liying Wang, Heran Deng, Xiaoyu Fang, TaoLang Li, Qianjun Chen, Jieqiong Liu   +5 more
wiley   +1 more source

A case report of a mammary gland type adenocarcinoma of the vulva in a patient with a concomitant breast cancer: a diagnostic challenge. [PDF]

Front Oncol
Nobile I, Tessitore A, Palumbo M, Boccia D, Mignogna C, Bifulco G, Della Corte L.   +6 more
europepmc   +1 more source

Cardiovascular β‐Adrenergic Receptor Distribution and Function: Influence of Species, Sex, Age, and Tissue

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Estrogen modulates β‐AR signaling in a context‐dependent manner influenced by species, sex, age, tissue, and vascular health, highlighting challenges in translating findings from experimental models to human cardiovascular physiology. ABSTRACT Cardiovascular diseases remain the leading global cause of morbidity and mortality, with notable sex‐specific ...
Basant Elsaid, Irakli Kopaliani, Birgit Zatschler, Ansam Seif, Stephan Speier, Andreas Deussen   +5 more
wiley   +1 more source

Single cell RNA-sequencing reveals that testosterone reduces estrogen signaling in the healthy human mammary gland. [PDF]

J Mammary Gland Biol Neoplasia
Phong KT, Song S, Kim EA, Conrad DN, Gartner ZJ.   +4 more
europepmc   +1 more source