Results 201 to 210 of about 42,336 (264)

Standardized Pipeline for Metabolism and Cognition in GO‐DS21 Mouse Model: Investigating Down Syndrome Comorbidities

Current Protocols, Volume 6, Issue 6, June 2026.
Abstract Down syndrome (DS) is the most prevalent form of intellectual disability (ID) globally, with an incidence rate of approximately 1 in 1000 births, affecting over 5 million individuals worldwide. DS is characterized by a genetic profile that predisposes individuals to a range of medical and cognitive conditions, including ID and obesity, which ...
Mohammed Selloum, Patricia da Silva‐Buttkus, Fabrice Riet, Nathalia R. V. Dragano, Lillian Garrett, Hugues Jacobs, Sabine M. Hölter, Nicolas Torquet, Birgit Rathkolb, Loic Lindner, Valerie Gailus‐Durner, Guillaume Pavlovic, Li Chan, Johannes Beckers, Benoit Petit Demoulière, Helmut Fuchs, Elodie Ey, Tania Sorg, Martin Hrabe de Angelis, Yann Herault, the GO‐DS21 Consortium   +20 more
wiley   +1 more source

Late gestational exposure to flutamide alters stromal composition and immune landscape in the rat mammary gland during pre-puberty, peri-puberty, and adulthood. [PDF]

Toxicol Sci
Tovar Parra D, McDermott A, Cardot J, Juarez MN, Joao F, El Omri-Charai R, Berthiaume L, Dhawan B, Aghigh A, Breton Y, Légaré F, Delbès G, Pelletier M, Audet-Walsh É, Plante I.   +14 more
europepmc   +1 more source

Single‐cell profiling reveals peripheral blood immune landscape remodelling in breast cancer lymph node metastasis

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
scRNA‐seq reveals pro‐metastatic neutrophil and exhausted T/NK subsets in BC patients with LN metastasis. Interferon‐stimulated neutrophils secrete LGALS9, drives T/NK cell exhaustion via HAVCR2. Neutralising LGALS9 restores T‐cell anti‐tumour activity, suggesting a novel therapeutic target.
Bo Chen, Kang Ma, Yunjie Wang, Liulu Zhang, Xinyue Feng, Cheng Long, Xuejing Tan, Kun Wang   +7 more
wiley   +1 more source

Spatial localization of avian and human influenza A virus receptors in male and female bovine reproductive tissues. [PDF]

Sci Rep
Poliakiwski BD, Minela T, Smith DJ, Seekford ZK, Cain JW, Polanco O, Johnson GA, Luense LJ, Ross PJ, Dimitrov KM, Lamb GC, Pohler KG.   +11 more
europepmc   +1 more source

Multi-omics profiling uncovers immune-molecular clusters with distinct chemo-immunotherapeutic vulnerabilities in a mouse model of triple-negative breast cancer. [PDF]

Mol Cancer
Castellanet O, Monatte J, Corvaisier N, Kaoutari AE, Kaya M, Ferreira L, Audebert S, Camoin L, de Nonneville A, Gonçalves A, Borg JP, Michea P, Maina F, Lamballe F.   +13 more
europepmc   +1 more source

Luminal hormone-responsive cells tune the regenerative remodeling of mammary glands in large mammals. [PDF]

Cell Discov
Li Y, Zhang L, Luo T, Zhang W, Wang T, Liu F, Lin S, Luo J, Liu J, Peng J, Wang C, Wang W, Shi H.   +12 more
europepmc   +1 more source

Elucidating cooperative genetic events in DCIS progression in mutant <i>p53</i>-driven breast cancer. [PDF]

Proc Natl Acad Sci U S A
Morrissey RL, McDaniel JM, Chau GP, Su X, V M, Chandra V, Dixon BREA, El-Naggar AK, Thompson AM, Lozano G.   +9 more
europepmc   +1 more source

Compressive stress-driven Piezo1 activation and Rho-ROCK mechanotransduction promote tumor progression via epigenetic mechanical memory. [PDF]

Sci Adv
Boyle ST, Gallego-Ortega D, Buckley EJ, Cognard E, Johan MZ, Esmaeili Z, Kamei M, Poole K, Samuel MS.   +8 more
europepmc   +1 more source

An in utero exposure to the synthetic estrogen diethylstilbestrol affects the fat pad composition in post-natal mammary glands. [PDF]

Toxicol Sci
Tovar-Parra D, McDermott A, Cardot J, Juarez MN, Joao F, El Omri-Charai R, Berthiaume L, Dhawan B, Aghigh A, Breton Y, Légaré F, Delbès G, Pelletier M, Audet-Walsh É, Plante I.   +14 more
europepmc   +1 more source

Cabergoline Prevents Postpartum Breast Cancer by Enhancing Mammary Gland Involution in Brca1-Mutant Mice and Reduces Risk in Younger Women

García-Sancha N, Corchado-Cobos R, Ghorayeb R, Blanco-Gómez A, Puértolas OC, Alonso-López D, Stoer NC, Mateo F, Espin-Garcia R, Nguyen LTN, Marzo-Castillejo M, Gough C, Milne K, Castillo-Lluva S, Rivas JDL, Pozo J, Orfao A, Palomero L, Pignatelli J, Sacristán-Horcajada E, Valero-Juan L, Patino-Alonso C, Perera D, Venkitaraman A, Mao J, Chang H, Jiménez-Navas A, Pérez-Baena MJ, Salvador N, Mendiburu-Eliçabe M, González P, Caleiras E, Peset I, Cenador MBG, Garcia-Criado FJ, Nelson BH, Botteri E, Pujana MA, Maxwell CA, Pérez-Losada J.   +39 more
europepmc   +1 more source