Results 121 to 130 of about 190,981 (166)

Osmotic Tension Asymmetry Drives Electrotactic Migration via PDLIM7‐Polarized Microfilament Coordination in Breast Cancer Cells

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This study establishes an electric field‐induced directional migration model using fluorescence tension probes to visualize microfilament forces and intracellular osmotic pressure dynamics in the electrotactic migration of breast cancer cells. This model delineates how electromechanical interactions among membrane potential, ion channels, OP, traction ...
Ling Zhu, Zihui Zheng, Wang Li, Chenyi Shou, Ying Zhao, Lijun Zhang, Xiaoli Shi, Yunfeng Hu, Huanhuan Zhao, Huiwen Wu, Jun Guo   +10 more
wiley   +1 more source

Protocol for establishing a chemoresistant orthotopic triple-negative breast cancer patient-derived xenograft model for preclinical drug testing. [PDF]

STAR Protoc
Tébar-García D, Barbella-Aponte R, Sánchez-López E, Picazo-Martínez MG, Gómez-Juárez M, Díaz-Piqueras Á, Pinedo-Serrano A, Sánchez-Olivares P, López-Rosa R, Cristobal-Cueto P, Rodilla V, Galán-Moya EM.   +11 more
europepmc   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, Volume 13, Issue 14, 9 March 2026.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Breast Cancer Reveals Latent <i>BMPR2</i>-Related Susceptibility to Pulmonary Hypertension. [PDF]

Circulation
Toro V, Mougin M, Brossat C, Jambon-Barbara C, Hlavaty A, Guay CA, El Kabbout R, Bilodeau C, Grobs Y, Martineau S, Breuils-Bonnet S, Abi-Sleimen A, Ruffenach G, Boucherat O, Bisserier M, Provencher S, Bonnet S, Montani D, Khouri C, Potus F.   +19 more
europepmc   +1 more source

Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This review delineates monoaminylation—serotonylation, dopaminylation, and histaminylation—as key post‐translational modifications beyond receptor signaling. It details their catalytic mechanisms, roles in gene expression and protein function, and implications in health and disease, aiming to bridge mechanistic insights with therapeutic potential ...
Yiqi Zhao, Hongli Zhang, Yating Yang, Wei‐Dong Chen, Yan‐Dong Wang   +4 more
wiley   +1 more source

Carcinogenicity of atrazine, alachlor, and vinclozolin. [PDF]

Lancet Oncol
Cattley RC, De Roos AJ, Mandrioli D, Pearce N, Pronk A, Soshilov A, Abarikwu SO, Baldi I, Barr DB, Freeman LEB, Bortoli S, Connolly A, Dalvie MA, Ferreira MJ, Genter MB, Le Hégarat L, Lorenzetti S, McLaughlin JR, Møller P, Montagner CC, Silveira HCS, Toyoda T, Volle DH, Benbrahim-Tallaa L, de Conti A, Facchin C, Kunzmann AT, Madia F, Pasqual E, Aix ML, Deng X, Dongoran RA, Olanipekun MT, Suonio E, Viegas S, Mattock H, Wedekind R, Schubauer-Berigan MK.   +37 more
europepmc   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

The influence of two neurohormones on breast cancer: prolactin and melatonin. [PDF]

Rev Assoc Med Bras (1992)
Ferreira CDS, Carvalho KC, Ferreira IDS, Cavalcanti GS, Cipolla Neto J, Zambotti PEO, Baracat EC, Soares Junior JM.   +7 more
europepmc   +1 more source

Single‐Cell Morphomechanics of Prostate Cancer‐Associated Fibroblasts Identifies Distinct Features Associated with Patient Outcome

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Cancer‐associated fibroblasts (CAFs) in prostate tumors exhibit distinct morphomechanical traits vs normal fibroblasts, including greater stiffness and volume, more elongated stress fibres, and larger and more elongated nuclei. These features, quantified through imaging and real‐time deformability cytometry, correlate with patient outcomes and can be ...
Antje Garside, Angela Jacobi, Shivakumar Keerthikumar, Vaibhav Mahajan, Michelle Richards, Birunthi Niranjan, Linda Teng, Nicholas Choo, Johannes Low Jun Wei, Gail P Risbridger, Mitchell G Lawrence, Anna V. Taubenberger   +11 more
wiley   +1 more source